@OatesLab
Account based inSwitzerland
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Laboratory of timing, oscillations and patterns at EPFL
Lausanne, Switzerland
Joined March 2019
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How does the segmentation clock instruct cells to form a somite boundary? Read our new pre-print “Clock driven waves of Tbx6 expression prefigure somite boundaries”, by @Olivier_Venzin and colleagues, to find out.
biorxiv.org/content/10.1101/…
Summary thread below: 1/15
2. The segmentation clock forms a densely connected network. We show here that, in addition to driving oscillations of dpErk activity (Simsek et al. 2023) and inhibiting the expression of ripply1/2 (Yabe et al. 2023), Hes/Her genes also drive oscillations of Tbx6.
14/15
We thank @chloe_jollivet, @nKiaru, @ORSPF, Clément Helsens, Luis G. Morelli and Koichiro Uriu for their great work, @GValentinEPFL and members of the Oates lab for their feedback and @ViventisMicro for their technical support.
15/15
But, what are the cells doing? Our step by step guide to following single cells in vivo is now out (in collaboration with @nKiaru) 🔬
But, what are the cells doing? Image Analysis pipeline to follow single cells in the zebrafish embryo biorxiv.org/cgi/content/shor… #bioRxiv
Our collaborative work with @mssakar on a robotic microsurgery platform to investigate the mechanics of zebrafish embryo elongation.
News article on our microsurgery platform. Please contact us if you would like to operate on your samples using our robot or build your own system. @eceozelci @OatesLab @NatureComms actu.epfl.ch/news/a-robotic-… #epfl
oaties retweeted
Excited to build on the footsteps of hugely #interdisciplinary mentors @StephanGrill @mpicbg @oateslab @epflsv as I make the transition to @TIFRScience as a group leader in September. 1/n
tifr.res.in/~dbs/faculty.htm…
symmetrylab.squarespace.com
The final version of our manuscript, where we investigate emergence of left-right symmetric somites in #zebrafish embryos is now out!
nature.com/articles/s41586-0…
@Sundar_Ram_07 @mpopov1c @AOates1 @EPFL_en @epflSV
Is left-right #symmetry a default state in somites? Excited to share our latest #preprint that counters the textbook view
@Sundar_Ram_07 @mpopov1c @AOates1
biorxiv.org/content/10.1101/…
The proposed adjustment mechanism does not depend on whether the somite interior is a fluid, or a yield stress material as long as the somite is in a uniformly flowing state
Many thanks to the amazing colleagues @OatesLab, @LeBIOP for phenomenal support & the incredible fish facility @EPFL_en
Special thanks to @EbisuyaMiki @XavierTrepat for the news and views piece on the article
nature.com/articles/d41586-0…