@NowickGroup

Student-led account. We are a chemistry research group @UCIchemistry and @UCIPharmSci.

 Irvine, CA
chem.uci.edu/~jsnowick/groupweb/index.html
Joined August 2020
  • Tweets169
  • Following207
  • Followers425
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New work from our group published in @PNASNews! Congratulations to @AdamGKreutzer, @G_Guagli, Stan Yoo, @CMTParrocha, Sarah Ruttenberg, and others, as well as our collaborators in the @WysockiVicki group at @OhioState, and the Lai group at @EinsteinMed pnas.org/doi/10.1073/pnas.22…

Probing differences among Aβ oligomers with two triangular trimers derived from Aβ | PNAS

The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely associated with the pathogenesis and progression of Alzheimer’s...

pnas.org
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Check out our new preprint up on bioRxiv now! This manuscript reports the generation and study of antibodies against an oligomer mimic of the Alzheimer's-related Aβ peptide. biorxiv.org/content/10.1101/…

Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer’s...

Antibodies that target the β-amyloid peptide (Aβ) and its associated assemblies are important tools in Alzheimer’s disease research and have emerged as promising Alzheimer’s disease therapies. This...

biorxiv.org
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Demain à 14h, l'@IBMM_Balard reçoit James Nowick @NowickGroup ! Cela se passe à l'@enscmchimiemtp.
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Read the latest issue of #PeptideScience, out now: ow.ly/7sRR50MCiul Thanks to @CMTParrocha and board member James S. Nowick ( @NowickGroup) for the cover image! @ampepsoc @UCIChemistry @UCI_SPPS
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Newest work from our group now out in @JOC_OL. Congrats to @MajKrumberger, @methylorniXing, @chelseajones873, and other authors not on Twitter. Great collaboration between our group and the NovoBiotic Pharmaceuticals team! pubs.acs.org/doi/10.1021/acs…

Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29

Abstract. This paper describes the synthesis and stereochemical determination of Novo29 (clovibactin), a new peptide antibiotic that is related to teixobac

pubs.acs.org
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Congratulations to @chelseajones873, @G_Guagli, and Grant for this latest work from our group on “Isobactins: O-acyl isopeptide prodrgus of teixobactin and teixobactin derivatives”. Out now in @ChemicalScience! pubs.rsc.org/en/content/arti… – at Irvine, CA

Isobactins: O-acyl isopeptide prodrugs of teixobactin and teixobactin derivatives†

The antibiotic teixobactin is a promising drug candidate against drug-resistant pathogens, such as MRSA and VRE, but forms insoluble gels that may limit in

pubs.rsc.org
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Congratulations @CarolynBertozzi, as well as professors Meldal and Sharpless! – at Irvine, CA
Jenn Prescher@jenn_prescher5 Oct 2022
Feeling all the feels this morn…Congratulations, @CarolynBertozzi and Profs. Sharpless and Meldal!!! Here’s a throwback photo in honor of #bioorthogonal chemistry. #ChemNobel
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Thanks to Bobby, Kent, and Sam for inviting me to the Foldamer Meeting. Stoked about molecules that fold for satisfaction. @aroralabnyu ⁦@nyuchemistry⁩
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Yesterday our group celebrated the beginning of summer with a wonderful lunch, a ferry ride, and some famous frozen chocolate covered bananas in Newport Beach.
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Check out this cover art based on our two latest papers by Dr.’s @morris_m_chem and @methylorniXing! Huge thanks to Jay Aranton for this artwork! – at Newport Beach, CA
Chemical Science@ChemicalScience7 Jul 2022
The new #ChemSciCovers have arrived! 🤩 🧬 James S. Nowick et al. (@NowickGroup, @UCIchemistry) present their new article! 🎪 Enantiomeric β-sheet peptides from Aβ form homochiral pleated β-sheets rather than heterochiral rippled β-sheets Read HERE: 🔗 ow.ly/YT8A50JQiqq
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Our newest review, congratulations to @CMTParrocha for publishing this! – at Irvine, CA
Wiley Chemistry@Wiley_Chemistry5 Jul 2022
Read the latest review in #PeptideScience: Current peptide vaccine and immunotherapy approaches against Alzheimer's disease by Peptide Science advisory board member @NowickGroup. 🔗: ow.ly/pGPC50JOJFs @UCIChemistry, @UCI_SPPS, @ampepsoc
Table of contents entry for the review in Peptide Science, Current peptide vaccine and immunotherapy approaches against Alzheimer's disease

ALT Table of contents entry for the review in Peptide Science, Current peptide vaccine and immunotherapy approaches against Alzheimer's disease

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Check out Maj’s poster tonight if you’re in San Diego for #NOS2022. – at San Diego, CA
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Congrats Dr. Li, @GSK is lucky to have you! – at Irvine, CA
Xingyue Li@methylorniXing6 Jun 2022
What an emotional past week it has been! I am thankful to all the wonderful people who supported me in my PhD journey. I will dearly miss friends from the @NowickGroup. With one great experience behind me, I am excited to begin my new adventure with @GSK in PA later this summer!
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Replying to @NowickGroup @XingyueLi6
Congrats Xing! Here is a milestone from 2012.
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Newest work from our lab out now in @ChemicalScience on "Enantiomeric β-sheet peptides from Aβ form homochiral pleated β-sheets rather than heterochiral rippled β-sheets". Congratulations to newly minted Dr. @XingyueLi6 and Stephanie Rios! pubs.rsc.org/en/content/arti…

Enantiomeric β-sheet peptides from Aβ form homochiral pleated β-sheets rather than heterochiral...

In 1953, Pauling and Corey postulated “rippled” β-sheets, composed of a mixture of d- and l-peptide strands, as a hypothetical alternative to the now well-

pubs.rsc.org
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Newest work from our lab out now in @ChemicalScience on "Visualizing the mode of action and supramolecular assembly of teixobactin analogues in Bacillus subtilis". Congratulations to Dr. @morris_m_chem and the rest of the authors! pubs.rsc.org/en/content/arti…

Visualizing the mode of action and supramolecular assembly of teixobactin analogues in Bacillus...

Teixobactin has been the source of intensive study and interest as a promising antibiotic, because of its excellent activity against drug-resistant Gram-po

pubs.rsc.org
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Congratulations to our newly minted PhD, Dr. Li @XingyueLi6! – at Irvine, CA
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Our group at this year’s Lee a Dinner Event for the @UCIChemistry Department. An incredible lecture by our department’s alumni and @NobelPrize winner Professor David MacMillan @dmac68, followed by a wonderful dinner and award ceremony.
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Proud of Jennifer, one of our many amazing undergraduate coworkers who make our lab a wonderful place to work in. She’ll make for an incredible pharmacist. – at Irvine, CA
UC Irvine@UCIrvine17 May 2022
#IamUCI: Jennifer Thulien Nguyen B.S. @UCI_SPPS The future pharmacist’s prescription for success at UCI included researching Alzheimer’s disease antibodies, working as a peer academic advisor & getting involved with ASUCI. Jennifer's story ➡️ bit.ly/3NlHVs7
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