@NickyScheefhals

Neurobiologist, fascinated by human brain development, synapse biology and iPSCs, postdoc @Radboudumc

 Utrecht, Nederland
nadifkasri-lab.com
Joined December 2017
  • Tweets164
  • Following231
  • Followers229
24Media
Beyond excited to share that this paper is out! mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function. Full article: doi.org/10.1038/s41467-022-3… @NatureComms @Westra_Manon @hdmacgillavry A thread🧵
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Why is human brain development, and particularly neuron morphogenesis, so slow and how is this linked to evolution? doi.org/10.1101/2024.12.28.6… We developed mouse brain organoid methods capturing differences to human and used these to address this. doi.org/10.1101/2024.12.21.6… 🧵 (1/n)
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The Spont meeting has come to a close, leaving us with a sense of accomplishment both scientifically and socially! What an amazing group of people! Looking forward to seeing everyone in Japan 🇯🇵 in two years! @GLB_Lab @NeuroAlc
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This week in Science, @ScienceAdvances, and @ScienceTM, the #PsychENCODE Consortium lay out findings based on examining human brains at the single-cell level. Learn more: scim.ag/73Y #DecodingTheBrain
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Nicky Scheefhals retweeted
Juan Burrone Lab@jbneuro19 Jun 2024
Thrilled to see this work published! Led by the amazing @Shorton_Neuro, we show a tight correlation in E and I along dendrites during circuit wiring. Check it out! @GuiVSNeves @vimast86 @rj_neuro @wellcometrust @BBSRC @dev_neuro @MRC_CNDD @KingsIoPPN doi.org/10.1016/j.celrep.202…
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What a joy co-chairing the session on human neuronal development and networks at #dnm24 with @NickyScheefhals. Big thanks to the brilliant speakers @CcileCharrier, @LaraJan34624220 and Katrin Linda — it was fantastic hearing about all the thrilling research!
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Excited to share our latest review on human brain evolution, development and tempo 🧠⏳. Huge thanks to Madeline Lancaster @mad_lancaster, Fenna Krienen @fennamk, and Katherine Pollard for writing this together - it was a blast working with you all! nature.com/articles/s41586-0…
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If you're interested in the Neural Circuit Development and Plasticity Summer School, there is still time to apply for a stipend from FENS/IBRO. Deadline April 23, 2024. More info about eligibility and the fantastic course program can be found here: utrechtsummerschool.nl/cours…
Harold MacGillavry@hdmacgillavry19 Mar 2024
Want to learn more about neural circuit development and plasticity? Join our annual Summer School in beautiful Utrecht/The Netherlands! We are very thankful to the support from FENS/IBRO who provide stipends for international students. More info: utrechtsummerschool.nl/cours…
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Next paper in the Blanpied lab paper parade! Here I, alongside @CajalMeMaybe, @Golgi_Willikers, and Twitterless Mike Anderson, describe the nanoscale organization of synaptic scaffolding protein SAP102 with respect to PSD-95.
bioRxiv@biorxivpreprint13 Sep 2023
Distinct SAP102 and PSD-95 nano-organization defines multiple types of synaptic scaffold protein domains at single synapses biorxiv.org/cgi/content/shor… #bioRxiv
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Nicky Scheefhals retweeted
Amélie Fréal@FreAmeLie18 Sep 2023
And it is out! 🥳🥳We spent a few years addressing the mechanisms of rapid AIS plasticity. We wanted to understand how sodium channels (Nav) are re-organized during AIS remodeling. science.org/doi/10.1126/scia…

Sodium channel endocytosis drives axon initial segment plasticity

Rapid activity-dependent sodium channel internalization at the axon initial segment tunes the action potential output.

science.org
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Interested to learn the latest about the development and plasticity of neural circuits? Check out the fantastic program of this Summer School in Utrecht/NL 👇 More info and sign up: utrechtsummerschool.nl/cours…
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Nicky Scheefhals retweeted
Shan Wang@ShanWan778348767 Feb 2023
Check out our new paper @STARProtocols. Here, we describe a step-by-step protocol to generate hiPSC-derived Glutamatergic/GABAergic (E/I) neuronal networks in vitro. Originally developed by my colleague @brittmossink, in the lab of @naelnadif, @SchubiNeuro doi.org/10.1016/j.xpro.2022.…
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Nicky Scheefhals retweeted
Wouter Droogers@WJDroogers2 Feb 2023
Delighted to share our review about 'Plasticity of postsynaptic nanostructure' @hdmacgillavry! We summarize literature on the functional nano-organization of synapses, and decipher what mechanisms could drive postsynaptic reorganization during plasticity doi.org/10.1016/j.mcn.2023.1…
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Please spread the word for this exciting Summer School on Neural Circuit Development and Plasticity in Utrecht! We are finalising the program, but already have confirmation from amazing speakers. Soon to be updated! For now, check out: utrechtsummerschool.nl/cours…
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Nicky Scheefhals retweeted
Alomone labs
@Alomone_Labs19 Jan 2023
Critical for proper glutamatergic signaling are mGluRs. But we haven't been sure about their distribution. Until now: new work from @NickyScheefhals @Westra_Manon @hdmacgillavry using super-res imaging (& our anti-mGluR5 😃) gives wonderful new insights! buff.ly/3HdNY1Y
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5/ We developed an inducible dimerization system to acutely re-localize mGluR5 to the synapse. This led to a severe deregulation of synaptic calcium signaling and indicates that preventing synaptic entry is critical for restricting mGluR5 overactivation.
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This paper has been long in the making, but now it’s out and perfectly wraps up my PhD! Huge thanks to @Westra_Manon @hdmacgillavry and all members of the MacGillavry lab!
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