Our goal is to understand the biology of neurodegeneration by using high-dimensional omic data & functional genomic at @WUSTLmed
St Louis, MO
Joined September 2018
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The NeuroGenomics and Informatics Center neurogenomics.wustl.edu is growing; new faculties will join in 2023. We are looking for an Executive Director (nature.com/naturecareers/job…) that will be instrumental in shaping the direction of the center moving forward. Apply now!
NeuroGenomics and Informatics Center retweeted
On Sept 17, I will join @BrightFocus Foundation to discuss the latest advances in blood-based biomarkers for Alzheimer’s disease.
✅ How blood tests may aide diagnosis
✅ Practical tips for using blood tests
#ENDALZ #Biomarkers
🔗 Register today: BrightFocus.org/ZoomInAlz
NeuroGenomics and Informatics Center retweeted
🔴 #NewPaperAlert
91 genetic loci associated with Alzheimer's disease and related dementias identified in a new @NatureRevGenet study.
🤝 International collaboration involving EADB, EADI, ADGC, CHARGE, FinnGen, GERAD, GR@ACE/DEGESCO & PGC-ALZ.
📄 nature.com/articles/s41588-0…
NeuroGenomics and Informatics Center retweeted
New Research Alert! 🚨
We’ve identified novel plasma proteins and metabolites linked to Alzheimer’s risk in both European and African ancestry groups. Most of these findings haven't been reported before!
Full study in @ALZJournal: alz-journals.onlinelibrary.w…
NeuroGenomics and Informatics Center retweeted
#AAIC2025 has been great so far and very proud of my team having done a stellar job on their 2 talks and 2 posters on sex and APOE*4 risk modifying genes in Alzheimer's disease!
NeuroGenomics and Informatics Center retweeted
Blood-based #biomarkers, such as p-tau217 & #amyloidβ 42/40 ratios, can be powerful tools for #Alzheimer's diagnosis. In our July issue, Drs. Tanner (@UTHealthSA) and Schindler (@WashUMedADRC) discuss how neurologists can select and interpret these tests for optimal outcomes. ow.ly/Z8Gg50WsXXW @SuzanneESchind1 @alzassociation @AANmember @ACPIMPhysicians @WashUNeurology
NeuroGenomics and Informatics Center retweeted
Around 5-10% of the #Alzheimers cases are early-onset, and are understudied. In a multiancestry genetic study of Early-onset AD we identified eight novel genes that point to dysregulation of glutamate, immune activation @WashUMedADRC @WashUNeurology
alz-journals.onlinelibrary.w…
NeuroGenomics and Informatics Center retweeted
Many articles reported using an antibody ... that didn’t even bind the key protein in Laflamme’s testing.
Those articles had been over 3,000 times.
The key question is:
◼️ Can binders achieve high specificity for every epitope & proteoform ?
Some investors assume an answer.
NeuroGenomics and Informatics Center retweeted
Join @WashUGenetics this Thursday (Dec. 12, 12pm CST) in Connor Auditorium when Dr. Alison Goate presents “Human genetics implicates Efferocytosis as an Alzheimer’s disease risk hub”, hosted by Dr. Peter Jin @PETERJIN999 !
NeuroGenomics and Informatics Center retweeted
Integrating GWAS and protein quantitative trait loci, scientists link 38 proteins to Alzheimer’s, 24 of them new. @WUSTL @NatureGenet @ccrugom ow.ly/hX7O50UoJTE
NeuroGenomics and Informatics Center retweeted
In collaboration with @laura_actg we benchmarked the @AlamarBio platform demonstrating that reliable measures key #alzheimers biomarkers in CSF and plasma with an accuracy similar to other well validated platforms @WashUMedADRC @WashUNeurology alz-journals.onlinelibrary.w…
Amazing work by @laura_actg and her lab identifying non-proteomics biomarkers, specifically circular RNAs for #Parkinsons, with AUC>0.95!! Impressive. Very pioneering work with important implications @WashUNeurology. Supported by @MichaelJFoxOrg
nature.com/articles/s41531-0…
NeuroGenomics and Informatics Center retweeted
Make sure to join us for AAIC advancement: APOE & Lipid Biology. There's going to be some great new insights into everything APOE! Abstract submission deadline is Dec 2. alz.org/apoe/overview.asp
NeuroGenomics and Informatics Center retweeted
Thrilled to share that my first-author ADAD paper is now published in Cell (Principle) @CellCellPress ! 🎉 This exciting milestone comes just before I make the move to join @MoffittNews, where I'll be working with Dr. Yu and Dr. Li @UrogerliMD .
I am deeply grateful for the opportunity to work and publish this research @WUSTL @WUSTLnews @WashUMedNeuro. The journey has been filled with invaluable lessons, experiences, and friendships that I will cherish for a lifetime @Neuro_Genomics @ccrugom.
A special thank you to all my friends, advisors, and mentors from my PhD studies @Mizzou - you all mean the world to me.
新的起点，新的征程！
Check out the full paper here!
CSF proteomics identifies early changes in autosomal dominant Alzheimer’s disease: Cell cell.com/cell/fulltext/S0092…
NeuroGenomics and Informatics Center retweeted
We leverage human multi-omic data to identify causal and druggable targets and to create novel predictive models for #Alzheimers . Come to use the four talks and four posters at the #AAIC24. neurogenomics.wustl.edu/the-…. @WUADRC @Neuro_Genomics @WashUNeurology
NeuroGenomics and Informatics Center retweeted
Heading out tomorrow for #AAIC24 and #PIA day. Come check out what we are doing at the intersection of ADRD, genomics, multi-omics, sex dimorphism, and ancestry! Also delighted to announce I am #ALZFunded @alzassociation with an AARG to advance our X chromosome work in AD *& PD!
11 of our NGI Center researchers who are showcasing their recent work on Alzheimer’s disease either through oral presentations, guided poster tours, and posters. Come see us in Philadelphia!
NeuroGenomics and Informatics Center retweeted
Excited to team up with @YangEricLi and @TristanLi_Lab to study microglial enhancers in Alzheimer's disease. We are so grateful for the generous support from @Neuro_Genomics! Can't wait to get started!
Great work from Tim Holman and team expanding our previous work identifying MS4A as the major regulator of TREM2 levels: molecularneurodegeneration.b…
'Variants in the MS4A cluster interact with soluble #TREM2 expression on #biomarkers of #neuropathology'
@RebeccaWinfree6 Emma Nolan, Logan Dumitrescu...Timothy J. Hohman @VanderbiltAlz @ADNI3study #AlzheimersDisease
bit.ly/3V2RNOe
NeuroGenomics and Informatics Center retweeted
'Variants in the MS4A cluster interact with soluble #TREM2 expression on #biomarkers of #neuropathology'
@RebeccaWinfree6 Emma Nolan, Logan Dumitrescu...Timothy J. Hohman @VanderbiltAlz @ADNI3study #AlzheimersDisease
bit.ly/3V2RNOe