Husband, Assistant Professor @WashUNeurosurg and @WashUGenetics interested in Bioinformatics, (Epi)genetics, Evolution
St Louis, MO
Joined August 2017
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So excited that our work is published in Science today! 📣We profiled regulatory elements from 1.1 million cells across 42 distinct human brain regions🧠, and associated relevant cell types to 19 common neuropsychiatric disorders. @ScienceMagazine #BICCN doi.org/10.1126/science.adf7…
Huge congratulations to Bing! 🎉Extremely well-deserved recognition for his pioneering contributions to epigenomics, and his unwavering mentorship has shaped so many trainees, including me!
Congratulations to NYGC CEO & Scientific Director Bing Ren, PhD, elected to the @theNAMedicine! His pioneering work in epigenomics has transformed our understanding of how genome organization and gene regulation shape cellular function and disease. nygenome.org/news-events/new…
Incredibly proud to announce that our DNA tokenizer EvoLen at the conference on language modeling (COLM) 2026! 🎉 This marks my first CS conference publication, and I could not ask for better collaboration @shangjingbo @NanHuang99!
🧬 EvoLen @ #COLM2026! 🔥
How should we tokenize DNA when there are no natural “word” boundaries?
EvoLen uses evolutionary constraint to guide biologically meaningful tokenization:
🔹 +27.4% motif preservation
🔹 +41–53% regulatory-region separation
🔹 Up to +14.4% evolutionary alignment
🔹 Strong gains on regulatory & cross-species prediction
Tokenization can be a biological inductive bias for genomic foundation models.
Huge thanks to my collaborators Xiaoxiao Zhou, Junxia Cui, Mario Tapia-Pacheco, and my advisors @TAmariuta , @YangEricLi , and @shangjingbo for their invaluable guidance and support!
Check out our work:
📄 Paper: arxiv.org/abs/2604.08698
💻 Code: github.com/HN020719/EvoLen
🤗 Models: huggingface.co/EvoLenTokeniz…
See you in San Francisco! ✈️
#Genomics #DNALanguageModels #AIforScience #DNA
Incredibly grateful to have received this @NIH R35 award! 🥳 Greatly appreciate my colleagues and the supportive environment at @WashUGenetics @WashUNeurosurg Looking forward to work with young talents to interpret human genetic variants via AI/ML and comparative genomics. 🧬
Congratulations to Yang (Eric) Li, PhD,@YangEricLi on receiving his first NIH R35 award! His research will use AI/ML, comparative genomics and single-cell data to better understand how human-specific genetic variation contributes to disease.
Read more:
genetics.wustl.edu/yang-eric…
Yang Eric Li retweeted
Excited to share Spatial-ATAC-Hi-C @naturemethods, spatial profiling of 3D genome organization + chromatin accessibility in tissue. Excitingly, it detects CNVs and SVs in tumors and reveals spatial heterogeneity.
Great collaboration with @RongFan8.
nature.com/articles/s41592-0…
Yang Eric Li retweeted
I’m delighted to share our latest work on the 3D epigenome of glial cell types in the developing human cortex, published today in Nature!
rdcu.be/CPbL73mz3STa
Yang Eric Li retweeted
Just want to give a shout-out to David Kelley @drklly who I think often does not get the credit he deserves (outside our core community).
I want to highlight why I think he is such a fantastic scientist and leader in regulatory genomics. 1/
Yang Eric Li retweeted
Congrats to Dr. Michael Province on being named a 2026 Dean’s Impact Award recipient! His leadership of the Long Life Family Study and decades of groundbreaking genetics research have shaped our understanding of longevity and advanced science globally.
faculty.med.wustl.edu/people…
Yang Eric Li retweeted
Thrilled to share that the @WashUGenetics Department has been ranked #5 in the nation for NIH funding in 2025! This achievement reflects the strength of our faculty, staff and trainees and their dedication to innovative scientific discovery.
Read more: genetics.wustl.edu/washu-med…
Thank you so much Dr. Yin Shen @YinShenLab for delivering a wonderful talk in our @WashUGenetics seminar series! Very exciting to learn how to high-throughout interpret genetic risk variant at single cell resolution!
So grateful for the support and kind guidance from my colleagues! 🧬🧠
Congratulations to Dr. Yang Li @YangEricLi on receiving the prestigious ALSF ‘A’ Award Grant to advance pediatric brain tumor research. The $800,000 award will support innovative single-cell genomic studies to better understand childhood brain cancers.
genetics.wustl.edu/yang-li-p…
So proud to have received generous support from @AlexsLemonade foundation🍋! We are dedicated to advance our understanding of aggressive pediatric brain tumors! 🧠🔬
Yang Eric Li retweeted
Get to know The Brain Tumor Center—where cutting-edge research meets compassionate care. Our team leads the fight against brain tumors with innovative treatments and a commitment to improving outcomes. Watch to learn more!
#TheBrainTumorCenter
#BTCSeries
#WashUNeurosurgery
Thrilled to be supported by @chadtough foundation! 🔬🧬Together with my wonderful colleagues and lab members, we will think deeper, make a difference in fighting DIPG/DMG, and give children the future they deserve! 🙌@WashUNeurosurg @WashuMedBTC @WashUGenetics
The ChadTough Defeat DIPG Foundation, together with its committed Family and Research Partners, is proud to announce its largest research investment to date — $5.4 million in funding for 11 new DIPG/DMG projects over the next three years.
Learn more: chadtough.org/record-breakin…
So honored to be a Rally Foundation awardee! 🥳Grateful for the support and kind guidance from my colleagues, and excited to contribute to advancing our understanding of pediatric brain tumors! 💪@WashUNeurosurg @WashuMedBTC @WashUGenetics
Big news: Rally awarded $5.5M in research grants to 75 researchers at 40 institutions, our largest ever! #RallyOn #ChildhoodCancer
Read more: werally.io/2025GrantAnnounce…
What a fantastic visit to @ClevelandClinic — reconnecting with old friends, meeting new ones, and diving into exciting science discussions. Grateful for the opportunity to learn so much about Alzheimer’s disease from true experts! Thank you so much @FeixiongCheng for inviting!
Yang Eric Li retweeted
Congrats to Yang Li, PhD, on receiving the Career Development Award from the Rally Foundation for pediatric cancer research. This will support his work studying the changes in gene activity in aggressive pediatric brain tumors. We commend your hard work and dedication!
This is such a amazing day to celebrate our 50 years of achievements and look forward to the next 50!
Yang Eric Li retweeted
We are proud to announce Bing Ren, PhD, as the new Scientific Director & CEO of the NYGC.
Dr. Ren brings his expertise in the fields of genomics & epigenetics to the NYGC & Columbia University, where he will hold a joint appointment.
For more on Dr. Ren: bit.ly/3DJXtah
Sush a fantastic time visiting @uthsc , meeting wonderful people at the Department of Genetics, Genomics and Informatics, and discussing science with a nice community. Thank you so much for the invitation!
An amazing holiday dinner with the lab! 😋So glad to see our team grow and thrive. Grateful for every lovely lab members, HAPPY HOLIDAYS! 🥳🎄🎉@WashUNeurosurg @WashUGenetics @YellowbellyStl
