Network Modelling Research Group @ Koç University #systemsbiology #networks #multiomics #dataintegration
Istanbul/Koc University
Joined July 2022
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NetLab retweeted
On #WorldLungCancerDay, we are very excited to share our latest paper @AdvSciNews on a novel bioengineered lung tumor model which mimics the aberrant sulfation of tumor matrices! 🫁 🧫🔬🧬
Full text: onlinelibrary.wiley.com/doi/…
Our new tool, pyPARAGON, for network-based omic data integration is now online! @KaanariciM 👏👏
Unveiling Hidden Connections in Omics Data via pyPARAGON: an Integrative Hybrid Approach for Disease Network Construction biorxiv.org/cgi/content/shor… #bioRxiv
Sina Dadmand and Şeyma Benge Uysal's work on the functional stratification of cancer drugs through integrated network similarity and exploring drug resistance patterns among cell lines, was presented by Sina Dadmand @RECOMBconf conference.
NetLab retweeted
Our new preprint is now online! Bengi (@bengiruken)-Kaan (@KaanariciM)-Cansu (@hcansud) worked together to show that networks of neurodevelopmental disorders and cancer can have shared mutations, proteins, and pathways differing in mechanisms, signaling strength, and outcomes.
Neurodevelopmental disorders and cancer networks share pathways; but differ in mechanisms, signaling strength, and outcome biorxiv.org/cgi/content/shor… #biorxiv_sysbio
Cancer latent drivers can additively intensify the signal when coupled with other activating mutations. They have low frequency and escape idenfication. In this study, we explored the potential impact of “latent drivers” on cancer progression and cataloged 155 latent drivers.
@bengiruken, @ntuncbag et al use a statistical methodology to identify potential latent driver mutations from public cancer bulk sequencing data.
@NetLab14
nature.com/articles/s42003-0…
Despite cancer-wide existence of a set of driver genes, having double mutations in those genes is cancer type specific.
NetLab retweeted
🎉Rounding out this first week of our Emerging Investigators highlights is Nurcan Tuncbag @ntuncbag with this excellent review on multi-omics computational approaches and their clinical applications!
Read it in full below 🔽
pubs.rsc.org/en/content/arti…
We are happy to be part of this collaborative work. Congrats Sina @sina_dadmand for his first paper!
Our COVID-19 study is out. A great collaboration we had with @NozluLab, @ntuncbag, @NetLab, @oergonul1, Fusun Can @kuiscid to determine COVID-19 associated network in plasma. @KUTTAM, @KocSciences
onlinelibrary.wiley.com/doi/…
NetLab retweeted
Our COVID-19 study is out. A great collaboration we had with @NozluLab, @ntuncbag, @NetLab, @oergonul1, Fusun Can @kuiscid to determine COVID-19 associated network in plasma. @KUTTAM, @KocSciences
onlinelibrary.wiley.com/doi/…
We have participated to @HBioinformatics with whole Network Modelling Lab!
For details on our presented posters:
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@KaanariciM has presented his method called PageRank-flux on graphlet-guided-network method(PRO-GGNet) for pathway reconstruction & multi-omic data integration.
