Prof. Biology, Brandeis. We study how flies/mosquitoes sense. Grateful to be part of @BrandeisMCB and @BrandeisNeuro. (R. Busby (logo) & C. Zhu).
Boston
Joined April 2010
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Fedex driver pulled up outside our house, then drove off without exiting vehicle. We were there/opened door. 30 min later app says we were "unavailable". Called CS, they claimed we had called to call off delivery at our house (which we had not). We are concerned.
Paul Garrity retweeted
Attending ASCB|EMBO? Join us for a Special Interest Subgroup on Sensory Receptors, featuring @EGouaux15625 @RachelleGaudet Maude Baldwin @MPIforBI Juan Du @DuLuLabs @CoreyAHAllard and Eric Mulhall, co-organized with Paul Garrity @Nemvec @ASCBiology @EMBO #cellbio2024
How do mosquitoes find people to bite & places to lay eggs? Turns out, sensing water vapor is key. In new work we (Tang et al.) ID mosquito receptors for dry/moist air. KO'ing them drops blood feeding and renders females unable to find water to lay eggs. pnas.org/doi/10.1073/pnas.24…
Paul Garrity retweeted
Ava Towle '26 studies how fruit flies sense temperature through G-Protein Coupled Receptors in the Shapiro Science Center lab, highlighting some of the exciting research on campus this summer. #Research #Brandeis
📸 Gaelen Morse/Staff photographer
ALT A diptych photo where the left image is that of biology student Ava Towle ’26 looking into a microscope at a lab in the Shapiro Science Center. The right image has a green hue and we see macro shots of fruit flies.
Paul Garrity retweeted
My autobiography is now published on the @NobelPrize website. It covers both my personal and professional life, highlighting the decisions and events that have had the biggest impact. I appreciate the opportunity to tell my story. Hope you enjoy reading it
nobelprize.org/prizes/medici…
Paul Garrity retweeted
Sugar detection in 3D: Structure of an insect gustatory receptor dlvr.it/T6K3Fs
Now out in final form: Structural basis of ligand specificity and channel activation in an insect gustatory receptor (w/ our collaborators in the Gaudet lab)
cell.com/cell-reports/fullte…
Paul Garrity retweeted
Friday's retreat of the Center for Molecular Investigation of Neurological Disorders brought together neuroscientists and related researchers from UP and @PennStHershey with guests like keynote speaker @Nemvec.
See all the pics on our Flickr album: flic.kr/s/aHBqjBkHiL
Sad news: John DeModena, long-time tech w/@wormraiserand friend to so many of us, has passed. Demo’s generosity of spirit and enthusiasm for life were inspiring. There will be a celebration of Demo’s life 1/27 in the Morgan library
Thanks Bing. Grateful to get to participate alongside people like Rachelle, Heather, Sanket, Richard, Doug and Willem. Have been wanting to know better what these things meant since the days of Gr28b!
For GR fans: Signature motif residues (TYhhhhhQF) make specific contributions to pore helix: T helps form hydrophilic path; Y binds lipid head group; QF gates pore entrance. Also new: intersubunit fenestrations of both GRs and ORs are inhabited by pore-penetrating lipids. 4/4
Take homes: Unlike known ORs, Gr9’s ligand-binding pocket is larger, solvent accessible and heavy on polar/aromatics. Using structure-based alignments and alphaFold, we leverage this to examine structural and chemical properties of GRs more broadly. 3/4
BmGr9 is a fructose-gated tetramer related to insect Odorant Receptors (ORs). It was beautifully characterized in 2011 by Sato et al., PNAS, and we decided to try and determine its structure. 2/4
Preprint: Structure of an insect gustatory receptor. Heather Frank, Sanket Walujkar, Richard Walsh, Willem Laursen, Doug Theobald, me and Rachelle Gaudet. Collaborative effort 5 years in the making! biorxiv.org/content/10.1101/… 1/4
Paul Garrity retweeted
We are back to business! The very first in vivo voltage imaging in Huang lab. Look at how this neuron changes firing mode. This simplistic voltage scope only costs ~$50k, mostly @Thorlabs parts. Let me know if you want a full part-list to build your own one.
