@NeleQuast

PhD in ML for structural bioinformatics @OPIGlets @UniofOx

Joined March 2020
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  • Followers74
Do you wish working with T-cell receptor structures was easier? Us too! STCRpy, our software suite for TCR structure parsing, interaction profiling and machine learning dataset preparation is now available! Github: github.com/npqst/stcrpy/ Pre-print: doi.org/10.1101/2025.04.25.6… 1/3

GitHub - oxpig/STCRpy

Contribute to oxpig/STCRpy development by creating an account on GitHub.

github.com
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Big thanks to my supervisors Charlotte Deane and @mijr12 for their supervision creating STCRpy. And all @OPIGlets for being such a fab group to be part of! 2/3
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We are looking forward to community contributions as more TCR structure research is conducted. We have also written some developer guidelines; if you have any questions just reach out! This will be my last tweet: nele-q.bsky.social 3/3
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I'll be presenting initial results or our new approach to protein flexibility estimation via uncertainty quantification at @workshopmlsb today. Drop by the poster session and check out the paper to find out more! mlsb.io/papers_2024/Estimati…
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The @OPIGlets are out in force at  @NeurIPSConf - check out our work at the @workshopmlsb and AIDrugX workshops today. @lucyvost, @nelequast and Nikhil Branson are presenting work on diffusion for small molecules, protein flexibility estimation and deep drug response models!
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I'm delighted to announce that our work on TCRBuilder2+, our high-throughput deep learning model for predicting #TCR structures, trained on over 50% more data than previous models, is now available as a preprint: biorxiv.org/content/10.1101/… Summary and links below -> 1/5

T-cell receptor structures and predictive models reveal comparable alpha and beta chain structural...

T-cell receptor (TCR) structures are currently under-utilised in early-stage drug discovery and repertoire-scale informatics. Here, we leverage a large dataset of solved TCR structures from Immunoc...

biorxiv.org
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TCRBuilder2+ pre-print: biorxiv.org/content/10.1101/… Structure predictions of over 1.5 million TCRs: doi.org/10.5281/zenodo.10854… Pip installable code: github.com/oxpig/ImmuneBuild… Observed T-cell receptor Space: opig.stats.ox.ac.uk/webapps/… 4/5
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Huge thanks to all my collaborators from @OPIGlets and @Immunocore on this project, @brennanaba, Bora Guloglu, Vijaykumar Karrupiah, Stephen Harper, @mijr12, and Charlotte Deane
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I've posted my first @OPIGlets blog summarising the Graphormer DL architecture! blopig.com/blog/2022/10/grap…
Headed in the right direction. The NHS moves to "examine the feasibility of moving the app to the decentralised model ... being chosen by more and more European countries"
ashkan soltani@ashk4n8 May 2020
Replying to @ashk4n
UK: NHS considers U-turn on contact tracing app with switch to Apple and Google model - Move comes as fears raised that NHS model may suffer technical glitches and prevent Britons from travelling abroad telegraph.co.uk/news/2020/05…

NHS considers U-turn on contact tracing app with switch to Apple and Google model

Move comes as fears raised that NHS model may suffer technical glitches and prevent Britons from travelling abroad

telegraph.co.uk
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Nele Quast retweeted
Ito@itoApp5 May 2020
Thanks to @BBCWorld for having us! We hope it helped to get a better understanding of the app we're offering. FYI: any help is very welcome, as we're an open source community. #decentralized #opensource #Covid_19
Clara Fischer // Voice of Tech@Voice_of_tech5 May 2020
I had an interview with @BBCNews about our app @itoApp. Tune into minute 3:22 until 10:25 to hear about our decentralised app. I'd recommend to listen to the whole show, it's a really good with lots of background info. bbc.co.uk/sounds/play/w172x2… #trackinfectionsnotpeople
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The u-turn in Germany is in huge part thanks to coordinated, speedy, relentless work from civil society. I’m in awe of friends and colleagues working tirelessly to stop the worst case scenario playing out on so many fronts right now.
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Nele Quast retweeted
Ito@itoApp26 Apr 2020
Working together with @TU_Muenchen on our app. So glad the german government picked up our decentralized approach with the @TCNCoalition protocol!
TU München@TU_Muenchen25 Apr 2020
#Corona #contacttracing apps: Interdisciplinary #contacTUM consortium presents a decentralized design using encryption to ensure #dataprivacy: go.tum.de/532404 #DCTS #coronaapp #covid19 #sarscov2 #dataprotection @TCNCoalition @BluetoothSIG
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Kurswechsel der Bundesregierung bei der #CoronaApp – Bundeskanzleramtschef Helge Braun: Wir „werden wir eine dezentrale Architektur vorantreiben, die die Kontakte nur auf den Geräten speichert und damit Vertrauen schafft“ tagesschau.de/inland/coronav…

Corona-Tracing: Bundesregierung denkt bei App um

Radikaler Kurswechsel: Die Bundesregierung setzt bei der geplanten Corona-Tracing-App nun doch auf ein anderes Konzept. Für die bisherige Wahl war sie heftig angegriffen worden. Von Kristin Becker...

tagesschau.de
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Nele Quast retweeted
Ito@itoApp21 Apr 2020
As one of the founding members of the @TCNCoalition, we're proud that @SZ has picked up our joint statement. Thanks to @SimonHurtz. BTW, ito has pitched the app at the @MinVWS appathon in the Netherlands this weekend. sueddeutsche.de/digital/coro… #trackinfectionsnotpeople #COVID19

Corona-App: Streit um Pepp-PT entbrannt

Der Streit zwischen Pepp-PT und DP-3T eskaliert: Knapp 300 Wissenschaftler warnen in einem offenen Brief vor "beispielloser Überwachung".

sueddeutsche.de
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Nele Quast retweeted
Ito@itoApp21 Apr 2020
BTW: We are an open-source community and 100% open for any collaboration. We do NOT promote competitive behaviour and wish to see more joint forces on this project. That's the reason we decided to be a founding member of the @TCNCoalition
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Thanks @MinVWS for an adrenaline-packed weekend. Great to meet the people working on privacy-protecting contact tracing and honoured to be able to represent the work of our teams from @itoApp & @TCNCoalition. Events like Appathon and @WirvsVirusHack get us all closer to our goal
Clara Fischer // Voice of Tech@Voice_of_tech20 Apr 2020
I would have never guessed that I'd end up in a pitch for the Netherlands Ministry of Health @MinVWS to show the app we have started to develop at the @WirvsVirusHack. More about our open-source, privacy-preserving corona tracing app @itoApp: ito-app.org. #COVID19
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