@NMatange

Microbiologist interested in bacterial adaptation to antibiotics

 Pune, India
nishadmatange.wixsite.com/bugs-and-drugs
Joined March 2019
  • Tweets421
  • Following168
  • Followers1.1K
7Media
Replying to @IISERPune
@IISERPune PhD admission forms for the Jan 2027 session are now LIVE. The last date to apply is 18th Oct 2026. For details and to apply, check the link below. iiserpune.ac.in/education/ad… Do help spread the word.
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Replying to @careiiserpune
@careiiserpune की VOICE फ़ेलोशिप में वैज्ञानिकों और ज़मीनी स्तर पर काम कर रहे पत्रकारों के बीच सीखने-साझा करने का शानदार सिलसिला जारी है। इस दौरान Nishad Matange ने फ़ेलोज़ के साथ बैक्टीरिया और वायरस जैसे महत्वपूर्ण बायोलॉजिकल विषयों पर बेहद उपयोगी चर्चा की। जानकारी, संवाद और सीखने-सिखाने से भरपूर यह एक शानदार सेशन रहा। @nutshal @JamwalNidhi
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coming soon....@IISERPune
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Bugs&Drugs retweeted
eLife - the journal@eLifeSep 4
Pathogen-phage geomapping to overcome resistance elifesciences.org/articles/1…

Pathogen-phage geomapping to overcome resistance

Targeted ecological sampling combined with a portable enrichment device rapidly yields a diverse array of bacteriophages against drug-resistant pathogens.

elifesciences.org
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Applications are now open for the 19th Young Investigators’ Meeting at Mohali (#YIM2027) The Young Investigators’ Meeting brings together young investigators and postdoctoral fellows from India and overseas for five days to exchange ideas and foster mentorship, networking, and collaboration in the life sciences. With @IiserMohali and @NABI_India, Mohali, as local hosts, the meeting is coming to Mohali, Punjab. 📅 22–26 February 2027 ⏳ Apply by: 30 September 2026 Apply here: buff.ly/RDL5V4I #YoungInvestigatorsMeeting #LifeSciences #EarlyCareerResearchers #IndianLifeScience @DBTIndia @DBS_IISERM @IndiaDST @ANRFIndia @ICMRDELHI @ugc_india @INYAS_INSA
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A new study in the August issue of #GENETICS provides insights into the microevolution of highly related Wolbachia genomes in #mosquitoes, revealing a strong link between genetic and cytoplasmic incompatibility pattern diversity. 🦟 📷️ Julien Amoros 🔗 buff.ly/fpcUdAP
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Latest study from the Bugs and Drugs Lab led by is now online @PLOSBiology We investigate how pre-existing polymorphisms in a signalling pathway in E. coli alter the capacity for evolving antibiotic resistance. journals.plos.org/plosbiolog…

Polymorphisms in a bacterial signalling pathway alter evolutionary routes of antibiotic resistance...

Why some bacteria evolve antibiotic resistance more readily than others is poorly understood. This study shows that naturally occurring single nucleotide polymorphisms in the PhoQP system changes how...

journals.plos.org
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more replies
We now exploit this system to ask a fundamental question, how do near-neutral sequence variants alter the propensity for AMR evolution. We show that epistasis between standing polymorphisms and adaptive mutations are a powerful force determining the evolution of resistance.
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This work may help explain why certain bacterial strains are more often associated with AMR variants than others. Thanks for @India_Alliance @ANRFIndia and @IISERPune for financially supporting this work.
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Bugs&Drugs retweeted
IISER Pune@IISERPuneJul 11
#Congrats to Dr. Chandrashekhar Borkar, faculty member in #BiologyDepartment, on receiving the prestigious #IBRORisingStar Award from the International Brain Research Organization @IBROorg!! Wishing him continued success as he begins his research journey at #IISERPune! iiserpune.ac.in/news/post/ib…
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Bugs&Drugs retweeted
eLife - the journal@eLifeJun 7
Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation elifesciences.org/articles/1…

Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation

B cell activation and antibody class switching requires coordinated metabolic rewiring, with essential roles for amino acid transport, cholesterol metabolism, and prenylation in driving proliferation...

elifesciences.org
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Our work on gene duplication as a transient mode of resistance acquisition covered by Saral AI. Do take a look at the video and the original article here: elifesciences.org/articles/9…

Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria

Gene duplication in antibiotic-resistant bacteria mitigates elevated demand for expression, facilitating adaptation to antibiotics and alleviating costs of proteolytic instability of the drug target.

elifesciences.org
DBT/WT India Alliance@India_AllianceMay 19
Our next Saral AI video with Dr. Nishad Matange explores how E. coli adapts to antibiotics under trimethoprim stress and what drives resistance over time. Watch now: youtube.com/watch?v=jnrYVc-A… @DBTIndia @wellcometrust @rajesh_gokhale @jarottingen @ANRFIndia @IISERPune
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Dr. Gayathri Pananghat, IISER Pune, shows how students move beyond classrooms and become part of real research environments early in their academic journey. ⏰ Last chance—apply for IAT 2026 before April 13, 2026 Apply now: iiseradmission.in
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I had the great pleasure of Guest Editing a Special Issue @ACS_Infectious together with @SandhyaGansan Kathryn Wicht and Angela Corona. A multi-continent collection on ID research in the Global South. The issue is now live! Read the editorial here: pubs.acs.org/doi/10.1021/acs…

Infectious Diseases Research in the Global South: Treatments and Treatment Failures

The 21st century has brought with it a decentralisation of science, allowing researchers all over the globe to contribute to scientific knowledge productio

pubs.acs.org
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Bugs&Drugs retweeted
Shraddha Karve@ShraddhaKBFeb 16
Out today! Our work on Genomic Surveillance of AMR in India. Also marks the first ‘home-grown’ paper from the lab! Please read and share. nature.com/articles/s44259-0… @KCDH_A @AnuragAgrawalMD @swissnexindia @KaminiWalia @AnshuB @Tavpritesh

Genomic landscape of antimicrobial resistance in India: findings from a multi-species surveillance...

npj Antimicrobials and Resistance - Genomic landscape of antimicrobial resistance in India: findings from a multi-species surveillance study

nature.com
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#IntheNews In another feature, the Indian Express published the work of Dr @NMatange! His team’s study reveals how E. coli survives antibiotics by temporarily copying key genes, buying time to evolve permanent resistance. 🔗: tinyurl.com/2r6tukkf
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Our work on gene duplications in antibiotic resistance covered by the Indian Express. @IISERPune @India_Alliance indianexpress.com/article/ci…

Why antibiotics are failing: IISER Pune scientists uncover bacteria’s new survival secret

A new study from IISER Pune reveals a hidden mechanism in E. coli that enables it to survive broad-spectrum antibiotics. Understanding this gene copying could be the key to tackling antibiotic...

indianexpress.com
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Read the research article here : elifesciences.org/articles/9…

Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria

Gene duplication in antibiotic-resistant bacteria mitigates elevated demand for expression, facilitating adaptation to antibiotics and alleviating costs of proteolytic instability of the drug target.

elifesciences.org
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Welcome Ashish! Looking forward to seeing the exciting work you do grow at IISER Pune
Ashish Nerlekar@ashish_nerlekar1 Dec 2025
VERY excited to start my own lab today at @IISERPune! Please check out our new website and keep an eye out for some cool #tropical #savanna #ecology research sites.google.com/view/nsel/h…
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