Microorgs, Victim of Bad Science, Note to MDs: Your patients are not statistics, neither are they lab rats! South African🇿🇦

Joined August 2021
This study of 77 females and males in Uruguay takes a deep dive into the uriobiome and compares bacterial diversity, intracellular bacterial communities and people with and without urinary symptoms. The study concurs with many previous studies that highlight the incompetence of traditional culture based diagnostics and the need for new microbiome based testing and treatments. Read here: journals.asm.org/doi/full/10…
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MythoFobe retweeted
Keep up with the latest research in benign urology with Uro-Lit Live! This month's discussion will be on October 29 at 4PM ET (3PM Central | 1PM Pacific) and will focus on publications pertaining to clinical research in female urology. Drs. Hokanson and Gadhvi will briefly go over their recent publications and then open the floor for discussion. More information: buff.ly/EaJbjTk
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“While molecular diagnostic methods have transformed our understanding of the urinary microbiome and implicated more complex bacterial communities in the etiology of UTI symptoms,59, 60, 74 their role in the diagnosis and management of UTI remains unclear.”
Updated AUA guidelines for rUTI: "...despite a growing desire for more accurate diagnostics for UTI in patients with suggestive symptoms, the answer to improved antimicrobial stewardship lies not in better testing, but in better clinical judgement." @USANZUrology @RACGP @PathologyRCPA auanet.org/guidelines-and-qu…
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This UTI research used nanogels combined with a special peptide to push gentamicin inside infected bladder wall cells to clear the infection. The researchers say nanogel delivers about 36% more antibiotic inside cells compared to standard antibiotic delivery methods. It is also quick releasing and exhibits low toxicity, causing minimal harm to cells. #chronicUTI #recurrentUTI #urinarytractinfection news.cuanschutz.edu/news-sto…
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Most lovable politician on the planet.
RETWEET if you stand with President Zelensky!
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Our brand new international communication team's first meeting was a huge success!
We are dedicated to facilitating open dialogue and maintaining a global network to stop #UTI To that extent, we've grown our communications team! We are all so excited to expand the platforms we use and the content we make, to connect with and grow our community ❤️ Stay tuned!
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Nice to know that all my screaming about the horror of #cUTI has been heard.
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No, we are not ahead of the game, we are 90 years behind. The microscopic method was developed in 1928 but was phased out in the 1970s. The replacement central laboratory methods and dipsticks were introduced without proper validation. A terrible blunder.
Wow this is really interesting- we can get it right in pets but not humans. Thanks for sharing. Is it common practice in veterinary to use this method then or are you ahead of the game?
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"Whatever is isolated from the urine, no matter what method is used, we have no means of knowing whether the microbe is friend or foe." @JamesMaloneLee3
I must keep restating this position - Whatever is isolated from the urine, no matter what method is used, we have no means of knowing whether the microbe is friend or foe. Our practice explicitly excludes isolate data from consideration. Answer: May be, may be not.
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It's the 3rd anniversary of Professor Malone-Lee's passing. Along with his book 'Cystitis Unmasked', he left behind a wealth of information here on his Twitter page. His huge contribution to UTI research and his kindness and respect towards his patients will never be forgotten. Thank you to all who continue his work🙏❤️ xitter.cf/JamesMaloneLee3
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"There is zero link between abundance on culture and causation." @JamesMaloneLee3
There again, an unsubstantiated assumption stated as fact. There is zero link between abundance on culture and causation. The harmless microbes, feeding on and cleaning up the inflammatory debris, will be abundant.
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“The bladder itself is generally considered a sterile environment” - Science shows the normal bladder the antithesis of sterile. Interpret that with the lense of Darwinian evolution and the entire urine culture edifice crashes to a pile of rubble. We must rethink UTI diagnosis.
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The diagnosis of Interstitial Cystitis is used to explain away the symptoms of UTI when the urine culture is negative. The urine culture is incompetent at excluding infection.
Replying to @JamesMaloneLee3
@JamesMaloneLee3 Hi professor. I was wondering why most people are getting told they have interstitial cystitis when alot of us only started having symptoms after a uti infection?