Our lab is using Legionella pneumophila as a tool to gain insights into basic mammalian cell-biological processes. @UCSF
San Francisco, CA
Joined March 2019
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A wonderful collaborative effort with Peter Walter @UCSF @stephenfloor @Lan_Wang_ @KroganLab @dlswaney led us to discover that Legionella toxin SidI possesses a tRNA-like shape and glycosylates the translation machinery to induce ribotoxic stress biorxiv.org/content/10.1101/…
Mukherjee Lab retweeted
The link for the faculty position is now posted! Deadline is October 15th. Please share widely with talented scientists in your network. Come join us at UCSF!
aprecruit.ucsf.edu/JPF05243
Search: Tenure track Faculty Position @UCSF in the Dept. of Micro and Immuno, with lab space at the Mission Bay campus! We seek a creative investigator with a strong independent research plan who will be a great mentor, colleague, and peer. Job ad soon. Assistant Prof level.
Mukherjee Lab retweeted
A surprise gift of « new curve crease origami » we call Lacrygami brought to us by a single cell (this is the first example of origami in a single cell)!! Will write a longer thread shortly describing our journey to discovery - in mean time, enjoy this beautiful cell.
The tiny predator Lacrymaria olor owes its shape-shifting ability to an “origami-like” cellular architecture, a new Science study finds. The results offer a glimpse into geometrical control of behavior in single cells.
Learn more in this week's issue: scim.ag/7eu
We are excited to report our latest finding that Legionella creates a unique niche that is independent of the host ER network.
Legionella uses host Rab GTPases and BAP31 to create a unique ER niche biorxiv.org/cgi/content/shor… #biorxiv_cellbio
Mukherjee Lab retweeted
#FluorescenceFriday #cellbiology #bioart
The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute:
Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the ER when they are actively transported at high speed along microtubules (MTs, yellow). ER tubules are also remodeled directly when they associate with the growing or shrinking ends of MTs.
doi.org/10.1016/j.cell.2018.…
Mukherjee Lab retweeted
NEW MBoC Call for Papers: Special Issue on Cell Biology of Infection!
Submit an article by Oct 30 to be considered by lead editors:
Nihal Altan-Bonnet, @nih_nhlbi
@Mukherjee_Lab, @UCSF
Learn more and submit: molbiolcell.org/cell-biology…
Mukherjee Lab retweeted
Exciting update!
Starting December 2, 2023, all ASCB member submissions to MBoC are ensured a thorough peer review. Simply ensure the corresponding author is an ASCB member to qualify.
Mukherjee Lab retweeted
🎁Interested in reading more about the study? Here is the N&Vs article written by Shu-Bing Qian and Saori Uematsu:
rdcu.be/dp6jU
nature.com/articles/s41556-0…
Thank you @NatureCellBio for accepting this work! We are absolutely thrilled!
☕️NEW: @Mukherjee_Lab, Walter & co show that the secreted #Legionella protein SidI is a #tRNA mimic and #glycosyltransferase that inhibits #HostCell translation by inducing #ribosome collisions & #ribotoxic stress response. @UCSF
rdcu.be/dp6gT
nature.com/articles/s41556-0…
Excited to announce that the Department of Microbiology and Immunology @UCSF is seeking candidates for a tenure-track faculty position at the Assistant Professor level.
aprecruit.ucsf.edu/JPF04655
Please RT.
Mukherjee Lab retweeted
We are delighted to announce our #ISFS2023 Fellows. Congratulations and welcome to ISFS! We will be highlighting them all through August! To learn more about our fellows visit: intersectionssciencefellows.…
Mukherjee Lab retweeted
Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.
Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda researchsquare.com/article/r…
Mukherjee Lab retweeted
Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in @Nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s41586-0…
Mukherjee Lab retweeted
I am happy to propose a model for mammalian #mitochondria UPR signaling, published @Nature.
nature.com/articles/s41586-0…
Mito protein misfolding induces two cytosolic signals –mtROS and mito protein precursor accumulation. These activate the mito UPR via a DNAJA1-HSF1 signaling axis.
Mukherjee Lab retweeted
Congratulations to the talented scientists joining our community of Pew scholars and fellows. We are so happy to have you!!!
🎉Congrats to our 2023 biomedical scholars and fellows!
These 37 early-career scientists are embarking on innovative research projects in neuroscience, microbiology, cancer research, and more. pew.org/3X1DwAU
Mukherjee Lab retweeted
Pleased to describe our latest contribution to the #Legionella world, as we define a clear role for unique phosphoribosyl-ubiquitin transferases in protecting the Legionella-containing vacuole from host driven disintegration.
biorxiv.org/content/10.1101/…
Mukherjee Lab retweeted
🚨We're back! Applications for the next #ISFS23 are now open! Postdocs interested in faculty careers: Apply to showcase your work, network w/ hiring institutions, receive mentorship, and connect w scientists from diverse backgrounds! Pls share broadly! intersectionssciencefellows.…
ALT Colorful ad for the ISFS event. Text says "Are you a postdoc going on the academic job market? Apply today to the Intersections Science Fellows Symposium. Deadline April 12, 2023. Symposium October 4-6, 2023. Showcase your science. Network with hiring institutions. Receive mentoring. Connect with peers. www.intersectionssciencefellows.com. Advancing diversity, equity and inclusion in academia."
So well-deserved! Congrats, Kevan!!!
This year’s Sjöberg Prize is awarded to professor Kevan Shokat, @UofCalifornia, for a huge scientific breakthrough that is bringing hope to people who are critically ill with lung cancer.
kva.se/en/news/sjoberg-laure…
@UCSFCancer @UCBerkeley @UCSF @kevansf
#Sjöbergprize
Mukherjee Lab retweeted
What a nice manuscript on a very interesting effector. Way to build on our initial characterization of SidI’s enzymatic activity and pubmed.ncbi.nlm.nih.gov/3212…. – at Kansas, USA
Mukherjee Lab retweeted
A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response. biorxiv.org/cgi/content/shor… #biorxiv_cellbio