@MuirLab

The Muir lab investigates the physiochemical basis of protein function in complex systems of biomedical interest.

 Princeton, NJ
muir.princeton.edu
Joined July 2021
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The @MuirLab’s Zoe Merz won the ACS Knowles Award for her abstract “Context Dependent Photocatalytic Proximity Reveals Interactors Unique to Receptor Combinations,” at the recent Bioorganic GRS+GRC. Congratulations Zoe (right)! Also pictured below, Gen Li (center, Chang Lab).
Group of attendees at a recent Gordon Research Conference, standing in front of an auditorium.

ALT Group of attendees at a recent Gordon Research Conference, standing in front of an auditorium.

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pubs.rsc.org/en/Content/Arti…

Traceless protein semisynthesis in cells using the promiscuous ultra-fast split intein NrdJ-1

Chemistry-driven approaches that allow proteins to be manipulated in ways not permitted by standard genetics are indispensable in the basic and applied bio

pubs.rsc.org
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Check out our latest efforts published in @ChemicalScience on characterizing and engineering the NrdJ-1 intein for protein biochemistry and chemical biology applications! Congrats to @XuanjiaYe, Josh, Christian, @thegoodnush and Juner! @PrincetonChem
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The Muir Lab retweeted
The Maze Lab@themazelabMar 18
Interested in histone H3 serotonylation? Then check out our brand new preprint out today! This work was spearheaded by Instructor extraordinaire, Dr. Min Chen of the Maze Lab, and represents another great collaboration with the labs of Drs. Haitao Li, @MuirLab, David Li, Samuele
bioRxiv Molecular Biology@biorxiv_molbioMar 18
Quinone reductase 2 reads H3 serotonylation to support neuronal maturation biorxiv.org/content/10.64898… #biorxiv_molbio
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With a background in math and physics, Postdoc Jeremy Owen's the first-ever computational theorist hired into the @MuirLab. He investigates the “dizzying complexity” of chromatin. Enjoy the first of our stories celebrating the postdocs of @PrincetonChem: bit.ly/4lgOmiy
Full-color image of Postdoc Jeremy Owen standing on one of the interior bridges at Frick Lab. (Photo: Mahrad Saghafi)

ALT Full-color image of Postdoc Jeremy Owen standing on one of the interior bridges at Frick Lab. (Photo: Mahrad Saghafi)

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The Muir Lab retweeted
Sid Jain@SiddhantUJainJan 2
2/9. This work was a true teamwork. Huge congratulations to our collaborators at @kadochlab , @MuirLab , @GygiLab , Michael Gross (WashU). Special thanks to Kadoch lab members - @CKadoch, Dr. Kaylyn Williamson, @alex2110x, Aasha Turner, Maxwell Allison, Kevin So!
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The Muir Lab retweeted
Sid Jain@SiddhantUJainJan 2
1/9. Happy 2026, everyone! We are excited to share our new study on how mSWI/SNF chromatin remodeling complexes interact with DNA sequence-specific Transcription Factors (TFs), out this week in Science! @ScienceMagazine Doi: doi.org/10.1126/science.aeb3…

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform

Mammalian switch/sucrose nonfermenting (mSWI/SNF) chromatin remodeling complexes modulate DNA accessibility and gene expression; however, their genomic targeting mechanisms remain incompletely...

science.org
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Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context and can describe how proteoforms are configured in functionally distinct complexes across biology. authors.elsevier.com/c/1lt5I…
Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context. Though specifically designed for the chromatin field, adaptions of the framework could be used to describe—and thus dissect—how proteoforms are configured in functionally distinct complexes across biology. Thank you to the many co-authors for your input and support. https://authors.elsevier.com/c/1lt5I3vVUPVb4c

ALT Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context. Though specifically designed for the chromatin field, adaptions of the framework could be used to describe—and thus dissect—how proteoforms are configured in functionally distinct complexes across biology. Thank you to the many co-authors for your input and support. https://authors.elsevier.com/c/1lt5I3vVUPVb4c

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Congratulations to our Tom Muir @MuirLab on being awarded the @AmerChemSociety's Ralph F. Hirschmann Award in Peptide Chemistry for exceptional achievement in the field. Well done, Tom! Enjoy our story here: bit.ly/3KhNITt
Full-color image of PI standing in his office, window in background.

ALT Full-color image of PI standing in his office, window in background.

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Congrats again to all our graduates!
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And last but not least, we have Dr Yingzi Huang, who presented a wonderful seminar on her chromatin within the context of DNA damage. Stay tuned for this story…
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Next, we have our newly minted Dr Esmat Hegazi, who gave an excellent talk on oncohistones. Look out for her work coming out soon… @esmathegazi
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With the start of the new academic year comes several farewells from our lab, as senior members of the lab graduate. First off, congratulations to our “transposein” Dr Yi Hua, who is heading off to @Stanford for a postdoc with @aliceyting
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Congratulations @MuirLab postdoc Jason Johansen-Leete on his Life Sciences Research Foundation Fellowship, sponsored by Amgen, for his project: “High-resolution mapping of the BAF interactome with novel chemoproteomic technologies.” Well done, Jason!
Full-color head-and-shoulders image of Jason.

ALT Full-color head-and-shoulders image of Jason.

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Congratulations to Tom for receiving the Ralph Hirschmann award in Peptide Chemistry! @PrincetonChem cen.acs.org/people/awards/AC…

ACS announces 2026 national award winners

The winners are being acknowledged for their outstanding achievements in chemistry across various fields in the discipline

cen.acs.org
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The Muir Lab retweeted
nature
@Nature5 Aug 2025
Nature research paper: Programmable protein ligation on cell surfaces go.nature.com/40HmcEs

Programmable protein ligation on cell surfaces

Nature - A synthetic biology system called SMART has been developed that uses conditional protein splicing for the programmable ligation of functional proteins from previously defined molecular...

nature.com
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The @MuirLab introduces a groundbreaking protein activation platform that allows “exquisite precision,” in @Nature last week. Enjoy our story on this @NIH funded research by Christian, Girum, Nicholas, Xuanjia, Yutong and Tom: bit.ly/3IThY6F
First author Christian Kofoed, a former postedoc in the Muir Lab, standing outside with a flowering tree behind him.

ALT First author Christian Kofoed, a former postedoc in the Muir Lab, standing outside with a flowering tree behind him.

Head-and-shoulders full-color photo of grad student Girum Erkalo standing in Frick Lab.

ALT Head-and-shoulders full-color photo of grad student Girum Erkalo standing in Frick Lab.

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The Muir Lab retweeted
Yael David@Yael_David__3 Aug 2025
Very happy to share this preview in @TrendsinBiotech two cool intein papers just out in @ScienceMagazine by @GMBurslem, @ophirshalem & @MuirLab. Beautifully written by my new postdoc, Kevin Schiefelbien🤩 @Penn @PrincetonChem authors.elsevier.com/a/1lXcK…
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Congratulations to Christian, Girum, Nick, Xuanjia, and Yutong! Link: nature.com/articles/s41586-0… @PrincetonChem @PrincetonInnov

Programmable protein ligation on cell surfaces

Nature - A synthetic biology system called SMART has been developed that uses conditional protein splicing for the programmable ligation of functional proteins from previously defined molecular...

nature.com
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We anticipate that this technology will enable targeted formation of biomolecules with reduced off-target toxicity. This paper is the start of many applications for SMART and stay tuned for more!
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