@MuirLab

The Muir lab investigates the physiochemical basis of protein function in complex systems of biomedical interest.

 Princeton, NJ
muir.princeton.edu
Joined July 2021
  • Tweets144
  • Following181
  • Followers1.2K
38Media
The @MuirLab’s Zoe Merz won the ACS Knowles Award for her abstract “Context Dependent Photocatalytic Proximity Reveals Interactors Unique to Receptor Combinations,” at the recent Bioorganic GRS+GRC. Congratulations Zoe (right)! Also pictured below, Gen Li (center, Chang Lab).
Group of attendees at a recent Gordon Research Conference, standing in front of an auditorium.

ALT Group of attendees at a recent Gordon Research Conference, standing in front of an auditorium.

1
2
12
906
The Muir Lab retweeted
The Maze Lab@themazelabMar 18
Interested in histone H3 serotonylation? Then check out our brand new preprint out today! This work was spearheaded by Instructor extraordinaire, Dr. Min Chen of the Maze Lab, and represents another great collaboration with the labs of Drs. Haitao Li, @MuirLab, David Li, Samuele
bioRxiv Molecular Biology@biorxiv_molbioMar 18
Quinone reductase 2 reads H3 serotonylation to support neuronal maturation biorxiv.org/content/10.64898… #biorxiv_molbio
1
7
22
2,586
With a background in math and physics, Postdoc Jeremy Owen's the first-ever computational theorist hired into the @MuirLab. He investigates the “dizzying complexity” of chromatin. Enjoy the first of our stories celebrating the postdocs of @PrincetonChem: bit.ly/4lgOmiy
Full-color image of Postdoc Jeremy Owen standing on one of the interior bridges at Frick Lab. (Photo: Mahrad Saghafi)

ALT Full-color image of Postdoc Jeremy Owen standing on one of the interior bridges at Frick Lab. (Photo: Mahrad Saghafi)

1
2
1
22
2,033
The Muir Lab retweeted
Sid Jain@SiddhantUJainJan 2
2/9. This work was a true teamwork. Huge congratulations to our collaborators at @kadochlab , @MuirLab , @GygiLab , Michael Gross (WashU). Special thanks to Kadoch lab members - @CKadoch, Dr. Kaylyn Williamson, @alex2110x, Aasha Turner, Maxwell Allison, Kevin So!
2
1
9
1,026
The Muir Lab retweeted
Sid Jain@SiddhantUJainJan 2
1/9. Happy 2026, everyone! We are excited to share our new study on how mSWI/SNF chromatin remodeling complexes interact with DNA sequence-specific Transcription Factors (TFs), out this week in Science! @ScienceMagazine Doi: doi.org/10.1126/science.aeb3…

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform

Mammalian switch/sucrose nonfermenting (mSWI/SNF) chromatin remodeling complexes modulate DNA accessibility and gene expression; however, their genomic targeting mechanisms remain incompletely...

science.org
6
36
195
27,256
Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context and can describe how proteoforms are configured in functionally distinct complexes across biology. authors.elsevier.com/c/1lt5I…
Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context. Though specifically designed for the chromatin field, adaptions of the framework could be used to describe—and thus dissect—how proteoforms are configured in functionally distinct complexes across biology. Thank you to the many co-authors for your input and support. https://authors.elsevier.com/c/1lt5I3vVUPVb4c

ALT Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context. Though specifically designed for the chromatin field, adaptions of the framework could be used to describe—and thus dissect—how proteoforms are configured in functionally distinct complexes across biology. Thank you to the many co-authors for your input and support. https://authors.elsevier.com/c/1lt5I3vVUPVb4c

4
42
1
196
13,118
Congratulations to our Tom Muir @MuirLab on being awarded the @AmerChemSociety's Ralph F. Hirschmann Award in Peptide Chemistry for exceptional achievement in the field. Well done, Tom! Enjoy our story here: bit.ly/3KhNITt
Full-color image of PI standing in his office, window in background.

ALT Full-color image of PI standing in his office, window in background.

1
2
16
1,820
Congratulations @MuirLab postdoc Jason Johansen-Leete on his Life Sciences Research Foundation Fellowship, sponsored by Amgen, for his project: “High-resolution mapping of the BAF interactome with novel chemoproteomic technologies.” Well done, Jason!
Full-color head-and-shoulders image of Jason.

ALT Full-color head-and-shoulders image of Jason.

1
4
1,422
The Muir Lab retweeted
nature
@Nature5 Aug 2025
Nature research paper: Programmable protein ligation on cell surfaces go.nature.com/40HmcEs

Programmable protein ligation on cell surfaces

Nature - A synthetic biology system called SMART has been developed that uses conditional protein splicing for the programmable ligation of functional proteins from previously defined molecular...

nature.com
4
50
1
221
21,916
The @MuirLab introduces a groundbreaking protein activation platform that allows “exquisite precision,” in @Nature last week. Enjoy our story on this @NIH funded research by Christian, Girum, Nicholas, Xuanjia, Yutong and Tom: bit.ly/3IThY6F
First author Christian Kofoed, a former postedoc in the Muir Lab, standing outside with a flowering tree behind him.

ALT First author Christian Kofoed, a former postedoc in the Muir Lab, standing outside with a flowering tree behind him.

Head-and-shoulders full-color photo of grad student Girum Erkalo standing in Frick Lab.

ALT Head-and-shoulders full-color photo of grad student Girum Erkalo standing in Frick Lab.

2
21
1,443
The Muir Lab retweeted
Yael David@Yael_David__3 Aug 2025
Very happy to share this preview in @TrendsinBiotech two cool intein papers just out in @ScienceMagazine by @GMBurslem, @ophirshalem & @MuirLab. Beautifully written by my new postdoc, Kevin Schiefelbien🤩 @Penn @PrincetonChem authors.elsevier.com/a/1lXcK…
1
5
1
16
2,622
The Muir Lab retweeted
SpliceBio@SpliceBioHQ12 Jun 2025
Yesterday, we announced the close of a $135M Series B financing to support clinical development of SB-007 for #StargardtDisease, including the ongoing Phase 1/2 ASTRA and POLARIS studies. Stay tuned as we advance our broader pipeline of genetic medicines. bit.ly/3ZpxYmi
3
1
5
1,224
The @SpliceBio platform is based on technology developed in @MuirLab at @Princeton.
SpliceBio@SpliceBioHQ12 Jun 2025
Yesterday, we announced the close of a $135M Series B financing to support clinical development of SB-007 for #StargardtDisease, including the ongoing Phase 1/2 ASTRA and POLARIS studies. Stay tuned as we advance our broader pipeline of genetic medicines. bit.ly/3ZpxYmi
2
4
607
Employing engineered split inteins to replace the internal regions of target proteins in a single reaction. science.org/doi/10.1126/scie… #NBThighlight

Protein editing using a coordinated transposition reaction

Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding...

science.org
3
23
1
109
11,831
A new protein editing technology from @MuirLab at @PrincetonChem could give scientists a new tool to combat disease in the human body: bit.ly/435Ok4j
Nicholas Tay, Tom Muir, and Yi Hua at Frick Lab

ALT Nicholas Tay, Tom Muir, and Yi Hua at Frick Lab

1
9
35
3,050
"Native nucleosomes know where to go!” Our Condense-seq paper is now published in Nature! 📄 nature.com/articles/s41586-0… I’m deeply grateful to my PhD advisor @taekjip and our incredible collaborators @MuirLab , @binzmit , Erika Pearce, and Ben Garcia lab!!
2
35
2
108
16,230
Congratulations @MuirLab on their groundbreaking method for protein editing recently out in @ScienceMagazine and featured in @Nature. Great work Yi, Nick, Xuanjia, Jeremy, Robert, and Tom! Enjoy our story on the details behind the science: bit.ly/44W8MqQ
Full-color image of the lead authors on the new research, including PI Tom Muir, standing in their lab at Princeton Chemistry.

ALT Full-color image of the lead authors on the new research, including PI Tom Muir, standing in their lab at Princeton Chemistry.

3
1
63
4,547
Sincere thanks to these wonderful young chemists, Kaylee and Caitlin, who’ve given their time to the @PrincetonChem ChemSTEM outreach program, presenting virtual talks to high school chemistry students on #gradstudentlife. Looking forward to more ChemSTEM programs next fall!
Full-color image of Kaylee and Caitlin standing on the walkway at Frick Lab.

ALT Full-color image of Kaylee and Caitlin standing on the walkway at Frick Lab.

2
5
1,060
Be a part of the Chandler Medal Lecture ft Prof Tom Muir @MuirLab and hosted by Prof Ann McDermott This talk will explore innovations in harnessing inteins for protein engineering, don’t miss this deep dive into synthetic biology! Join this Thursday 3/13 @ 4:30p, Havemeyer 209
1
1
754
The Muir Lab retweeted
Kadoch Lab@kadochlab21 Feb 2025
Great to have our annual @kadochlab -@MuirLab think tank collaboration meeting, this time up in Boston!
2
18
1,960
Load more