Professor and Principal Investigator, Molecular Physiology and Biophysics | Faculty Director, Metabolomics Core. Carver College of Medicine, U of Iowa.
Iowa City, IA
Joined May 2017
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1/n. Final version now online @MolMetab! Especially for labs newer to metabolomics, we hope this clarifies the need to freeze tissues immediately after loss of perfusion to preserve the in vivo metabolism. sciencedirect.com/science/ar…
Ever wondered how quickly mouse tissues need to be frozen to preserve the in vivo metabolome? Immediately after disrupted perfusion. We show here that this applies to the broad metabolome, between-genotype differences, and 13C-isotopologue distributions. biorxiv.org/content/10.1101/…
Eric Taylor retweeted
Congrats Miranda, Taekyung and @HosungBae! Hosung just opened his lab at U Iowa. Please apply for a postdoc position!
science.org/doi/10.1126/scia…
Eric Taylor retweeted
Also excited to share that I have recently launched my lab at the University of Iowa @IowaMed @IntMedatIowa! We are now recruiting postdoctoral fellows interested in using metabolomics and isotope tracing to unravel inter-organ metabolism. Please RT and apply if you’re interested
Eric Taylor retweeted
Thrilled to share that I’ve joined @FIU and the @FIU_CTS in Port St. Lucie as an Assistant Professor! Excited to kick off this new chapter in research, collaboration, and mentoring.
#NewFaculty #FIU #TranslationalScience #AcademicTwitter #ResearchLife
Eric Taylor retweeted
We r excited to announce the publication of our work in PNAS! This work, which began in early 2017 @uiowa with recruiting MS patients & HC, sheds new light on the critical role of the gut microbiome in MS #microbiome #MultipleSclerosis #symbiont 1/n 🧵 pnas.org/doi/10.1073/pnas.24…
Eric Taylor retweeted
Hello everyone! I am helping to organize a one-day symposium on fluorescent metabolite biosensors and their use in metabolism research. It will be May 12-13 and associated with the Cold Spring Harbor Laboratory “Mechanisms of Metabolic Signaling” Symposium. Our field needs to be able to visualize metabolism with spatial and temporal resolution and this symposium will explore what to do and how to do it, with experts in metabolism and biosensor development and use. Please join us! meetings.cshl.edu/meetings.a… -JR
How do cells respond to physiologically high O2 levels? In research just published in Science Advances (science.org/doi/10.1126/scia…), we investigating respiratory epithelia since their contact with air exposes them to some of the highest O2 levels in the body.
In work led by @B581434 (Bo Ram Kim) and co-corresponding with Mike Welsh, we show that basal airway stem cell mitochondria signal high O2 levels via mitochondrial citrate export.
High O2-induced mitochondrial citrate export leads to selective histone acetylation and differentiation into ciliated airway cells, which are critical for clearing mucus and pathogens from the lungs. Our findings may inform mechanisms to enhance lung airway repair after injury or treat other conditions where the number of ciliated cells is insufficient.
Thanks also to co-authors @adam_rauckhorst, Michael Chimenti, Tayyab Rehman, Henry Keen, and Phil Karp
Eric Taylor retweeted
Thanks to @nih_nhlbi for the direct support for the project and highlighting the publication. Read behind the paper story at Discovery of the first functional ion channel in extracellular vesicles. communities.springernature.c… #exosomes #ionchannels
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Have you ever wondered how mitochondrial and cytosolic pathways for de novo lipogenesis (DNL) interact?
We did!
Published Online today (cell.com/cell-metabolism/ful…) and led by first-author @adam_rauckhorst, we traced 13C-labeled lactate/pyruvate, acetate, the ketone acetoacetate, and leucine in several mouse models of disrupted hepatic mitochondrial and cytosolic acetyl-CoA generating pathways.
Surprisingly, deleting the mitochondria citrate carrier (CiC) increased DNL from both exogeneous and leucine-generated acetoacetate. Overall, our findings delineate a mitochondrial-cytosolic DNL substrate supply network that may guide more accurate therapeutic development for MASLD and T2D.
Many thanks to our expert collaborators: No X Ryan Sheldon, now leading metabolomics at the @VAInstitute, who helped start the project and develop the necessary mass spec methods with @adam_rauckhorst; for @StanislawDeja and @Isotopomer for deuterium tracing by NMR and careful contibutions to quantitatively framing our mass spec data; and Tom Vallim of @TarlingVallim for guidance with in vivo gene deletion by AAV CRISPRs.
Please also see the exciting co-published manuscript from @WellenLab and Christian Metallo Labs (cell.com/cell-metabolism/ful…) showing that bempadoic acid does more than just inhibit ACLY!
@FOEDRC, @UIowaResearch, @UIMolecPhysBio
The truly immersive John Luther Adam’s Inuksuit!
Performed by 100+ percussionists at Iowa City’s City Park, with Hancher Auditorium. @HancherUI @CityOfIowaCity @IowaCityofLit
G3 storm arriving with lights likely most visible Saturday. #aurora #northernlights #spaceweather #iowa
The northern lights could be seen as far south as Iowa, Oregon and Pennsylvania, according to the Space Weather Prediction Center.cbsloc.al/3ZRjbSd
Eric Taylor retweeted
So grateful for support of @RsdpScholars @umnmedschool and many mentors and colleagues who helped get this far! I’m excited to keep doing science with a great team. #teamplacenta
Eric Taylor retweeted
Very happy to share our study of human photoreceptor cell development finally out today in @jclinicalinvest! The cover image is an example of the sort of retinal organoids we used to model the inherited disease caused by NR2E3 variants. Check out those photoreceptors!!
#Cover: Human organoid models of retinal #development: buff.ly/3VoKL6I
#Image: Scanning electron micrograph of mature human retinal organoid derived from a patient with NR2E3-associated enhanced S-cone syndrome;#Credit:Arwin Shrestha
@StemCellsEh @IowaMed
#Ophthalmology
Eric Taylor retweeted
Excited to share our recent work on the surprising effects caused by loss of malonyl-CoA synthesis in liver. Outstanding work by @StanislawDeja and the whole lab. Thank you @Cell_Metabolism, @AmberMuellerPhD and the reviewers that made the paper better!
authors.elsevier.com/sd/arti…
Eric Taylor retweeted
Metabolism is really just a list of compounds that Chuck Norris allows to cross the mitochondrial inner membrane
Eric Taylor retweeted
Excited to share our new discovery of a mitochondrial isoprene transporter published today in @NatureCellBio and led by @mitojondrion! Interesting example of transporter dual functionality.
#Mitochondria
nature.com/articles/s41556-0…
Eric Taylor retweeted
An entirely new paradigm for the regulation of mTORC1 is coming, addressing long-standing questions about where and when mTORC1 acts on diverse substrates. Congratulations @DemetriadesLab! biorxiv.org/content/10.1101/…