@Mitch__Farrell

Neural dynamics of motivation and memory / Mahler Lab Alum / Puerto Rican🇵🇷

 Irvine, CA
Joined April 2018
  • Tweets88
  • Following451
  • Followers338
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I am eally thrilled to share my first postdoctoral paper out in @NatureComms. Incredible collaborative effort! Many thanks to all the people involved and especially to @MarsicanoLab and Lisa Roux (first paper of the lab 🥳). nature.com/articles/s41467-0…

Endogenous cannabinoids in the piriform cortex tune olfactory perception

Nature Communications - Whether and how cannabinoid type-1 receptors impact sensory functions in vivo is largely unknown. Here, authors show that their endogenous activity controls network dynamics...

nature.com
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Glad to see my work finally gets published🥺🥺🥺 Extracellular ATP neurotransmission and nicotine sex-specifically modulate habenular neuronal activity in adolescence jneurosci.org/content/early/…
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Excited to share a review that @marykaylobo and I wrote on novel neural mechanisms related to psychostimulant use! I was so happy to have this opportunity to shine light on some of the most interesting recent work within our field! authors.elsevier.com/c/1hqoZ…
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I just feel so lucky to work with this amazing people! @lukesjulson we are doing something right 😉
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New paper out studying the postnatal development of PV interneurons in a truly collaborative project. Thanks to @jess_cardin @martin_a_vinck @heyclaireward @AntaraMajumdar @bonafide_kasra for the great work and team spirit! nature.com/articles/s41380-0…

Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics

Molecular Psychiatry - Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics

nature.com
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Mitch Farrell retweeted
Richard Lab@RichardLab_3 Jan 2023
Happy new year! Start 2023 out right by checking out our new preprint on work led by @A_K_Scott examining encoding of cue-elicited reward seeking by ventral pallidal GABA neurons! biorxiv.org/content/10.1101/…

Ventral pallidal GABAergic neuron calcium activity encodes cue-driven reward-seeking and persists...

Reward-seeking behavior is often initiated by environmental cues that signal reward availability. This is a necessary behavioral response; however, cue reactivity and reward-seeking behavior can...

biorxiv.org
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Massively excited to share our lab’s first original research paper! Amazing work by @bren_abdelmesih illuminating the role of PeFA Ucn3 neurons at the intersection of stress and infant-directed behavior. Special thanks to collaborator @GraveNeurosis nam04.safelinks.protection.o…
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Mitch Farrell retweeted
Mary Kay Lobo@marykaylobo12 Sep 2022
Congratulations to @RianneThoughts who received the Michael Shipley Neuroscience Postdoc Award! Recognized by critical thinking and passion for continued learning in neuroscience & honors the legacy of Dr. Shipley the founding Director of @UMMedNeuro Program in Neuroscience.
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Defended! The biggest thanks to @svmahler for taking a shot on me and molding me into the scientist I am today. Much love to Mahler Lab and those who supported me 🥳 I'm thrilled to start my new journey at @lukesjulson Lab at Albert Einstein College of Medicine as a #K00 fellow!
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Orbitofrontal cortex populations are differentially recruited to support actions biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Mitch Farrell retweeted
Stephen Mahler@svmahler20 Jul 2022
Very excited to start on this @UCIrvine collaboration! We will examine how early life adversity resulting from resource scarcity alters transcriptional landscapes that may predispose heroin #addiction #SABV @ICAN_UCI @ucicnlm @UCIrvineSOM @ExoNeuro @z_baram @vivekenigma @MWoodLab
UCI Charlie Dunlop School of Biological Sciences@UCIBioSci20 Jul 2022
BioSci is part of a nearly $3.5 million project to understand the opioid crisis. Professor of Neurobiology and Behavior, Stephen Mahler, is the lead principal investigator, examining how early-life adversity influences adult addiction. bit.ly/3B0UMgv @svmahler #UCIBioSci
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I'm so excited that our paper on neural representations of compulsive drinking decision-making signals is finally out in Nature Communications! A big thanks to everyone who helped! #alcoholresearch #AUD #neuroscience #ephys #NIAAA #IUPUI @NatureComms nature.com/articles/s41467-0…

Compulsive alcohol drinking in rodents is associated with altered representations of behavioral...

Nature Communications - Compulsive alcohol drinking is a core feature of alcohol use disorder. Here the authors find that in rodents, neural signals in a key decision-making brain region (dmPFC)...

nature.com
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Very excited to share the 2nd installment of my PhD work out now in Translational Psychiatry! We find that early life adversity causes anhedonia for opioid drugs in males, similar to what we have seen for food, social reward, and other drugs... 🧵 1/4 nature.com/articles/s41398-0…

Enduring disruption of reward and stress circuit activities by early-life adversity in male rats

Translational Psychiatry - Enduring disruption of reward and stress circuit activities by early-life adversity in male rats

nature.com
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Mitch Farrell retweeted
Luke Sjulson@lukesjulson15 Jun 2022
Excited to share my lab’s first preprint! This project was a wild ride, and I couldn’t be prouder of @ezfermino and @soyoun_neurosci, who spearheaded it. Please RT and follow them - they are both superstars who will be tweeting lots of cool science in the years to come!
Eliezyer de Oliveira@ezfermino15 Jun 2022
Our new preprint (with @soyoun_neurosci and others) addresses a mystery in neuroscience: the entire brain fires during movements, so how does that not interfere with every other brain function? Hint: it involves #manifolds! biorxiv.org/content/10.1101/… 🧵1/13
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Our new preprint (with @soyoun_neurosci and others) addresses a mystery in neuroscience: the entire brain fires during movements, so how does that not interfere with every other brain function? Hint: it involves #manifolds! biorxiv.org/content/10.1101/… 🧵1/13
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Mitch Farrell retweeted
Stephen Mahler@svmahler27 May 2022
👁️4 a #postdoc on brain mechs of reward & how they r affected by developmental insults? Want to develop rat behav. models of disorders? We have a special opportunity for a 'well-paid' ($60K+) position 4 new PhDs, starting as late as early spring '23 in my lab.Intnl scientists OK!
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YAYYY, my big paper from my postdoc on #microglial pruning of stress-sensitive CRH+ neurons during early-life stress is finally out!!! This has been >5 years in the works, so big shout out to all co-authors, and especially my mentor @z_baram (thread below) cell.com/cell-reports/fullte…

Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing...

Early-life adversity (ELA) promotes lifelong aberrant stress responses and vulnerability to mental illnesses. Bolton et al. identify poor dynamics and hypothalamic CRH neurons’ excitatory synapse...

cell.com
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Mitch Farrell retweeted
Jibran Khokhar@DrJKhokhar21 Mar 2022
Collab paper with @WilderTD and @DrKyleSmith is finally out after a long & arduous peer-review journey! Chronic chemogenetic manipulation of ventral pallidum targeted neurons in male rats fed an obesogenic diet: authors.elsevier.com/c/1enJH… (50 days free-access link!) @DartmouthNeuro
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Meet @tuliberalarts #gradstudentspotlight 🎓 Andre Toussaint is a doctoral student in the Cognition and Neuroscience Program who was recently awarded a prestigious Simons Foundation Junior Fellowship. Read more here! liberalarts.temple.edu/news/… #templeuniversity #neuroscience
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ACNP@ACNPorg24 Feb 2022
BLA & mPFC inputs to VP-projecting NAc D1-MSNs/D2-MSNs change in different manners after cocaine CPP and abstinence. While inputs on Vp-projecting D1-MSNs show postsynaptic plasticity inputs to VP-projecting D2-MSNs show presynaptic plasticity rdcu.be/cG0cf @yonikupchik
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