@MillerLabCSB

Lab for Synthetic and Spatial Tissue Dynamics. At @MGHCSB @harvardmed

 Boston, MA
csb.mgh.harvard.edu/miller
Joined November 2017
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  • Following111
  • Followers174
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nature.com/articles/s41592-0… 1/3 Ever wondered how to perform spatial transcriptomics in tissues that are difficult to section? Want to combine this with in situ or in vivo microscopy? Check out my first paper as a (co-)corresponding author now out in @naturemethods!
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i3 SYMPOSIUM 2022. We are hosting our 3rd annual online symposium on translational imaging. This time the topic is Imaging Drug Action. Outstanding lineup of speakers. Come join on Oct 27 & 28! #MolecularImaging. Please retweet. i3.mgh.harvard.edu/drugactio…
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Our study on single-nucleus and spatial profiling of pancreatic cancer was published today @NatureGenet and will be the cover story in the August issue: tinyurl.com/2eac6tnv.
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#Ionizingradiation as a #bioorthogonal approach to trigger-activating #prodrugs in #bioconjugation and delivery is a novel method of ensuring biologically-specific #tumortargeting! Read this latest report by Miller and coworkers @MGH_RI & more go.acs.org/1Ig
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Excited to announce that the Hwang lab will officially launch in July 2022 in the Simches Research Bldg on the main campus of MGH as part of the Center for Systems Biology @MGHCSB, Dept of Radiation Oncology, and Center for Cancer Research @MGHCancerCenter.
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Excited to share our work combining clinical imaging, multi-modal/scale molecular imaging and modeling to improve BRAFi drug efficacy in lesions encountered in vivo. tinyurl.com/2cpnrhxf Appreciate the #teamwork #collaboration #mentors esp @MGHCSB @MillerLabCSB @WeisslederLab
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Great research coming out of @MGHCSB @WeisslederLab for #earlydetection of #PancreaticCancer using #extracellularvesicle analysis. science.org/doi/10.1126/scia…

Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer

Single-vesicle analysis of human plasma with the sEVA method allows detection of stage 1 pancreatic cancers.

science.org
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Want to learn more about translation imaging of inflammation? Check out the outstanding speaker lineup for our 2021 virtual symposium. October 28/29. i3.mgh.harvard.edu/inflammat…
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👍 Huge congratulations Fernanda and co-authors for producing this incredible story. For the readers: have a look at the the MANY human data, which are an invaluable addition to the mechanistic studies performed in animal models.
Fernanda G. Herrera@fg_herrera6 Sep 2021
Delighted to present our article in Cancer Discovery @CD_AACR, which uncovers a breakthrough in #cancerimmunotherapy #Oncology Low Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy cancerdiscovery.aacrjournals… @CD_AACR amazing editorial board!!TX
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Happy to share this new work on #extracellularvesicle published in @natBME. Great team work from @HakhoLee_Lab @WeisslederLab @MGHCSB @MGH_RI @JongminPark_lab
Nature Biomedical Engineering@natBME28 Jun 2021
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma rdcu.be/cnlPP
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💪Congratulations @csgarrix for this new achievement! Amazing work focusing on dendritic cells and CD40 to treat #bladdercancer. And it’s great to know that the findings are already being used to initiate a clinical trial. 🤞 #cancer #Immunotherapy stm.sciencemag.org/content/1…
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In a @NatureNano study, #MGRI @MGHCSB researchers demonstrated how oncogenic KRAS signaling controls albumin-drug uptake in mouse tumor models, and that manipulating nutrient signaling could enhance efficacy of nab-paclitaxel. @MillerLabCSB @WeisslederLab nature.com/articles/s41565-0…
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Out today in ⁦@NatureMedicine⁩! Work w/ ⁦@dliu_ccb⁩: Evolution of delayed resistance to immunotherapy in a melanoma responder ⁦@MGH_RI⁩ ⁦@MGHSurgery⁩ ⁦@MGHCancerCenter⁩ ⁦@DanaFarber⁩ ⁦⁦@DanaFarberNews⁩⁩⁩ nature.com/articles/s41591-0…

Evolution of delayed resistance to immunotherapy in a melanoma responder

Nature Medicine - Genetic and protein expression analyses of serially collected tumor biopsies from a patient with melanoma treated with immune checkpoint inhibitors provide insights into tumor...

nature.com
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Excited to share my #FirstFirstAuthorPaper (w/ co-first @alifarhat40 & PI @aarmey) out in Cell Reports today titled "Modeling cell-specific dynamics and regulation of the common gamma chain cytokines" doi.org/10.1016/j.celrep.202…
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Fun facts re human body: 30 x 10^12 cells, 90% of which are hematopoietic total turn over ~4 million cells/sec major contributors to turnover: RBCs, neutrophils and intestinal epithelia adipocytes, muscle cells and neurons get exceptionally old doi.org/10.1038/s41591-020-0…
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Genetic alterations can cause tissue pathology and disease. But diseases also shape the genetic composition of tissues! See below our new study on how increased HSC proliferation in atherosclerosis accelerates clonal hematopoiesis. cell.com/cell/fulltext/S0092…

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

Heyde et al. propose that clonal hematopoiesis can be a symptom rather than a cause of atherosclerosis, since this disease increases hematopoietic stem cell division, which results in accelerated...

cell.com
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Happy to share a new paper from our team @Nature. We show that myeloid cell differentiation is not random. Instead, is spatially organized by unique vessels in the bone marrow. nature.com/articles/s41586-0… More info in the thread below
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Cycling between life and death hms.harvard.edu/news/radiati… @HMS_SysBio @MGHCSB @MillerLabCSB

Radiation Vulnerability

Tumor-suppressor protein dynamics drive cellular radiation survival

hms.harvard.edu
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Congratulations to @MIT educators @LindaGGriffith1 and Douglas Lauffenburger, the recipients of the 2021 Gordon Prize “for the establishment of a new biology-based engineering education" #NAEawards @MITdeptofBE Read more about recipients here: bit.ly/2L3R922
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The Center for Systems Biology (CSB) at the Massachusetts General Hospital (MGH) Research Institute and Harvard Medical School (HMS), in Boston is seeking outstanding scientists for faculty positions to start July 1, 2021. @WeisslederLab @MGH_RI @HMS_SysBio @MGHMedicine
Weissleder@WeisslederLab26 Dec 2020
We have opened the search for new FACULTY with an Immunology background. Incredible opportunity, colleagues and Institution @MGHCSB @MGH_RI @SurgeryMGH @MGHMedicine @HMS_SysBio . Spread the word !!! Search closes 2/1/21 Link: csb.mgh.harvard.edu/faculty_…
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