@MikePetassi

Postdoc in Greene lab @DNAcurtain @ColumbiaPS \\\ PhD from @JoePetersLab

 New York, NY
Joined December 2020
  • Tweets10
  • Following134
  • Followers109
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mCherry lysate looking good! Ice bucket is blown away @DNAcurtain
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Happy Transposon Day 2022! Today is the 120th birthday of Barbara McClintock, founder of the #transposon field and Nobel laureate. Please celebrate with us by using the hashtag #TransposonDay2022. How has Barbara McClintock or her work influenced you? mobilednajournal.biomedcentr…
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Transposons take over #CRISPR2022! @JoePetersLab @MariuszCzC @PhoebeARice
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Very happy to announce our TnsB paper is out! It includes 2.7 Å cryo-EM structure of transposase bound to transposon end. Wonderful collaboration with @JoePetersLab. #cryoEM @IIMCB_Poland @Struc_biol_PL @FNP_org_pl doi.org/10.1016/j.molcel.202…
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🔥hot off the press 🔥 It's been an exciting few months 😊 Kellogg lab's first paper with @JoePetersLab now out in Science science.sciencemag.org/conte…
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Happy #TransposonDay2021 from the Peters Lab at Cornell University, Barbara McClintock's training ground!
Mobile DNA@MobDNAjournal
16 Jun 2021
Happy Transposon Day 2021! On June 16 in 1902, Barbara McClintock was born, founder of the #transposon field and Nobel laureate. We, the editors of @MobDNAjournal, are curious to hear how she or her work influenced your career! #TransposonDay2021 mobilednajournal.biomedcentr…
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Congrats to @kellogg_liz and co for the first lab pre-print and very happy to be on board! More Tn7-like transposon structure and mechanism to see, this time of the #CRISPR-Cas wielding RNA-guided variety.
Liz Kellogg ❄️🔬@kellogg_liz
26 May 2021
The @kellogg_liz lab has posted its first pre-print! Here we continue our mechanistic studies of 'jumping genes' or transposases, in close collaboration with @JoePetersLab on CRISPR-associated transposases ( Type V-K CAST elements). biorxiv.org/content/10.1101/…

Structural basis for target-site selection in RNA-guided DNA transposition systems

CRISPR-associated transposition systems allow guide RNA-directed integration of a single DNA insertion in one orientation at a fixed distance from a programmable target sequence. We define the...

biorxiv.org
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Excited to be a part of this awesome work from @shen_yao10 and @alba_guarne lab! Finally get to see this piece of the mighty Tn7 transposon!
Alba Guarne@alba_guarne
25 May 2021
Incredibly proud of this structure and @shen_yao10 work. I could not have anticipated how much it would explain @j_ortega_McGill @JoePetersLab @McGillMed Structural basis for DNA targeting by the Tn7 transposon biorxiv.org/content/10.1101/…

Structural basis for DNA targeting by the Tn7 transposon

Tn7 transposable elements are unique for their highly specific, and sometimes programmable, target-site selection mechanisms and precise insertions. All the elements in the Tn7-family utilize a AAA+...

biorxiv.org
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Expanding our understanding of dual-pathway transposition (1 - plasmids; 2 - chromosomal attachment sites) with Tn7-like elements one family at a time. New preprint from bioinformatics wizard @PopoMicro on Tn7-CRISPR-Cas12k
Joseph E. Peters@JoePetersLab
10 Feb 2021
Tn7-CRISPR-Cas12K transposons categorize guide RNAs for different types of integration targets. Previously shown for type I-F3 systems. Grad student @PopoMicro shows an analogous process evolved with Cas12K systems. 1/6 biorxiv.org/content/10.1101/…

Tn7-CRISPR-Cas12K elements manage pathway choice using truncated repeat-spacer units to target tRNA...

CRISPR-Cas systems provide a defense against mobile elements. These defense systems have been naturally coopted multiple times for guide RNA-directed transposition by Tn7-like transposons. Elements...

biorxiv.org
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