Continuing dose de-escalation series for tPA/DNase in #pleural #infection ADAPT-3 (n=100) used starting dose of 1mg tPA/5mg DNase: - 95% success rate - total tPA dose 6mg (median) per pt 28% needed dose escalation 25% had 2nd chest drain Thx team! @estee_lau @MichDonaghy @SophieKriv @CalvinSidhu @e_fysh @udit_chaddha @sfaiz212 @ProfJDChalmers @JoseMPorcel @dfellerk @ASundaralingam @tsanz_thoracic @PleuralPOCUS @ALATorax

Our Clinical Pleural Fellowship (since 2009) at Sir Charles Gairdner Hospital, Western Australia is a 12-month program; next intake Feb 2027. Our centralised service handle high volume of tertiary/quaternary cases; emphasizing training on knowledge/problem-solving + procedural skills. Please RT to anyone interested. @tsanz_thoracic @INSPIREresp_UK @UKPleura @pleuralwales @wabipconnect @ARNS_UK @TheRACP @RACSurgeons @deefitz1901

Early View: EPIToME (Early Pleurodesis via IPC for Treatment of Malignant Effusion) by @deefitz1901 et al: algorithm integrates results of AMPLE-1/-2, MIST-2, ASAP, IPC+ trials (how we manage MPE last few yrs) - Indwelling pleural catheters for symptomatic MPEs unless contraindicated - If lung trapped: discharge + symptom-guided drainage - If full lung expansion: talc via the IPC + daily drainage @tsanz_thoracic @CHESTOncology @PleuralPOCUS @ALATorax @EuroRespSoc @AAB_IP @wabipconnect @SMNYCT @APSRapsr

Time of yr when we farewell our fellows. Meanwhile @MichDonaghy (ex-fellow) returned to visit be4 her new consultant job at Derry. Look forward to her flying the pleural flag in N Ireland! @UKPleura @BTSrespiratory @tsanz_thoracic @AAB_IP @TheRACP @ARNS_UK @db_fitzgerald @PleuralPOCUS

Great day out in London with ex-pleural fellows: THX those who made the special trip from Dublin @db_fitzgerald, Belfast @MichDonaghy, Brighton @SophieKriv. Those couldn't come missed out on fun++. Always proud to see what our fellows have achieved @tsanz_thoracic @kristiwithaB @pleuralfellow @Char_les_Wong @BRONCHOLOGISTS @LuiMacy @CarolynPeddle @nc_huan @ChloeCharl49409

#PLEURAL_PEARLS_WA 35 Diaphragmatic #pleural reflection extends far below the #lung esp posterio-laterally. Percutaneous hepatic procedures often transgress the pleura; any bleeding or bile leak (see doi.org/10.1002/rcr2.70259) can accumulate as pleural effusion. #LiverTwitter #POCUS @PleuralPOCUS @UKPleura @AAB_IP @SIRspecialists @theliverdoc @VCU_Liver @AASLDtweets @wabipconnect @BRONCHOLOGISTS

🔴Time for Clinical Pleural Fellows 2026 SCGH, Western Australia. We offer diverse pleural pathologies, procedures, research & train thought leaders. RT pls @UKPleura @BTSrespiratory @tsanz_thoracic @TheRACP @pleuralwales @INSPIREresp_UK @OxfordRespTrial @KingsResp @BristolLung

Early X'mas @NMHS_WA. THANKYOU to our Pleural Team @Charlies_Resp for the hardwork making a productive 2024. Fellows @MichDonaghy @neeros5 Nurse chloe_charlesworth Specialists @e_fysh @MacGuyver_MD @aBronchoscopist many RMOs @theofficialduji Pathologist @Celia__Green

🟩Syphillis pleural effusion. Surprise what you can find in pleural fluid. Case @RespirologyAPSR from Dr Shaldbolt @DrMatthewIng @MichDonaghy @e_fysh from @Charlies_Resp. Read DOI: 10.1002/rcr2.70069 @tsanz_thoracic @APSRapsr @TheRACP @PleuralPOCUS @AAB_IP @wabipconnect @ARNS_UK

🟩Past, present & coming pleural clinical/PhD fellows. We are never afraid to challenge belief or try new concept (from pleural med to Peking Duck pizza). Contact us for 2026 #Pleural Fellowships @Charlies_Resp Perth, Australia. @tsanz_thoracic @UKPleura @irishthoracicS @TheRACP

🟢WHY BREATHLESS WITH PLEURAL EFFUSION? @db_fitzgerald will correct misconceptions at The Australasian Pleural Series on Sept 4. You'll think differently after this succinct 15min summary. RT Link in 🧵@tsanz_thoracic @PleuralPOCUS @TheRACP @PulmPEEPs @AAB_IP @irishthoracicS

People with pleural effusion tell you they are breathless bending forward? PLEASE-3 study investigates clinical relevance of 'bendopnea': Bianca Iacopetta @kristiwithaB @CarolynPeddle @DrMatting @MichDonaghy @AiLingTan16 doi.org/10.1002/rcr2.1410 @WestmeadHub @uwanews @PleuralPOCUS

Large (>80%) primary spontaneous pneumoThx are as successfully managed by conservative care (ie no drainage) as smaller ones. See @ERSpublications sub-analysis of the PSP trial by @GKeijzers_EM @MichDonaghy @First_do_noharm Drs Weatherall+Beasley+Ball+Simpson @PleuralPOCUS

The AUSTRALASIAN PLEURAL SEMINAR (TAPS) SERIES starts 31 January 2024 @ 18:00 NZ; 16:00 AEDT; 13:00 (WA). #pleura #MedEd Dr Dhaval Thakkar: Secondary Pneumothorax

Wishing you Merry X'mas & Happy New Year from our Pleural Unit at Institute for Resp Health/Univ Western Australia/Sir Charles Gairdner Hospital. Big thank you to all our staff, patients/family &collaborators! @Charlies_Resp @UWAresearch @NCARD_research @UKPleura @PleuralPOCUS

#Pleural Group early Xmas dinner under Perth sunset. Thx for everyone’s hardwork for another productive yr! @Charlie’s_resp @db_fitzgerald @estee_lau @MichDonaghy @neeros5 ⁦⁦@CarolynPeddle⁩ ⁦@Pedro_Lopez1291⁩ ⁦@NCARD_research⁩ ⁦@lihinibasnayake⁩