@Meitinger

Assistant Professor interested in Mitosis, Genome Stability, Cancer and Centrosomes

 Onna, Okinawa
groups.oist.jp/cellpro
Joined April 2011
  • Tweets206
  • Following282
  • Followers382
29Media
Very happy to see our paper “Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization” featured in the @NatureComms Editors’ Highlights (Cancer). Many thanks to the editors for highlighting our work. nature.com/ncomms/editorshig…
2
5
542
Our study on the mitotic stopwatch is out. We demonstrate that USP28 interacts with 53BP1 to stabilize p53 and show that cancer cells frequently harbor mutations that impair stopwatch assembly, thereby suppressing the mitotic stress response. nature.com/articles/s41467-0…

Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization

Nature Communications - USP28 and 53BP1 proteins form a complex to stabilise the tumour suppressor p53, which is required to protect cells from mitotic stress and subsequent genome instability....

nature.com
1
7
30
3,333
Congratulations to Hamzah for receiving the EMBO Molecular Medicine Poster Prize at #MBSJ2026. Well deserved! aeplan.jp/mbsj2025/en-embo.h…

The 48th Annual Meeting of the Molecular Biology Society of Japan

aeplan.jp
4
261
We’re recruiting a Postdoctoral Researcher at @OISTedu (Okinawa, Japan) to explore how mitotic stress shapes aging. If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you. More info: oist.jp/careers/postdoctoral…
3
5
597
Join us for the #CellDivision2026 meeting in Okinawa. Abstract Submission Deadline: Nov 3. oist.jp/conference/cell-divi…
4
4
542
Join us for the Cell Division Meeting in the Pacific Island setting of Okinawa. Hosted at OIST, this symposium brings together leading researchers to explore emerging roles of the cell cycle in development, cancer, and aging. Registration now open: oist.jp/conference/cell-divi…
7
12
1,095
Excited to share our new preprint on @biorxivpreprint! We show that USP28 mutations found in cancer block its interaction with 53BP1, disrupting p53 stabilization. Check out the full story... biorxiv.org/content/10.1101/…
1
8
24
2,016
@biorxivpreprint @Midori_RuruOta
2
188
Check out our review on "PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential". Everything you need to know about centriole duplication, mitotic stopwatch and TRIM37-mediated cancer-specific vulnerabilities. @Midori_RuruOta onlinelibrary.wiley.com/doi/…

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Centrosomes catalyze the assembly of a microtubule-based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo-Like Kinase 4...

onlinelibrary.wiley.com
1
3
20
650
Franz Meitinger retweeted
Zuzana Storchova@ZStorchova6 Mar 2025
For all cell biologists: join the conference organized to celebrate 50 years of German Society for Cell Biology! zellbiologie.de/dgz-internat… Registration is open! See you in Heidelberg. #DGZ50
4
1
12
814
We wish you Happy Holidays from Okinawa!
1
2
14
839
A prolonged mitosis is characteristic of defects that drive genome instability. What are the underlying causes and broader implications of prolonged mitosis? Check out our review... authors.elsevier.com/sd/arti…
5
20
1,680
Interested in Base Editing and Genetic Screening? Check out our method chapter: link.springer.com/protocol/1… Esther Ng did an excellent job developing these methods in our lab. The constructs will soon be available on @Addgene Many thanks to @OISTedu for supporting open access!

Genetic Engineering and Screening Using Base Editing and Inducible Gen

Genetic engineering and screening in human cells are powerful techniques for the precise and comprehensive identification and analysis of gene and protein domain functions. Genome-wide knockout...

link.springer.com
4
9
682
We are happy to share our review on the 53BP1-mediated activation of the tumor suppressor p53. We summarize the cell cycle-depend functions of 53BP1 during mitosis and interphase and address its role in maintaining a healthy tissue. authors.elsevier.com/sd/arti…
8
32
1,869
Franz Meitinger retweeted
Paola Laurino@PaolaLaurino10 Aug 2024
We are looking for faculties interested in #Energy and #Sustainability broadly defined. oist.jp/careers/faculty-posi…

Open Faculty Positions

oist.jp
2
19
40
5,725
Big thanks to all @DKW_2024 participants for excellent science, engaging conversations, and mountain excursions! We hope to see everyone in Oxford in 2027. Thanks also to our generous sponsors @EMBOevents @Co_Biologists @eLife @Chromosoma_EB @snsf_ch @UNIGEnews @EMBO
1
19
3
48
8,561
Our paper "Control of cell proliferation by memories of mitosis" is out @ScienceMagazine. We show that cells can detect and memorize defects in mitosis to eliminate potentially damaged cells. @OISTedu @Meitinger @oegemadesai_lab science.org/doi/10.1126/scie…

Control of cell proliferation by memories of mitosis

A study reveals how cells measure time spent in mitosis and relay that information to daughter cells.

science.org
7
56
1
197
44,624
🔬Groundbreaking research by OIST Cell Proliferation and Gene Editing Unit and collaborators show how cells become ultimate protectors against cancer!🧬Did you know cells sense defects by measuring the duration of #mitosis? @MeitingerOhta @oegemadesai_lab ow.ly/Gknt50R4KZk
12
3
23
3,492
Franz Meitinger retweeted
OIST_KonoLab@OIST_KonoLab22 Feb 2024
Our new paper is out in #NatureAging ! Cell membrane damage induces senescence! 1st authors --> @kouchocolate @OIST_KonoLab @apple_hani nature.com/articles/s43587-0…
7
32
5
120
139,238
分からない病気は、治すことができません。 @MeitingerOhta’s Unitでは、細胞分裂はどのように正しく行われるのか、うまくいかなかった場合は何が起こるのかを研究。#がん の新たな治療 標的を探しています。#NewFacultyOfOIST @Meitinger @Midori_RuruOta 記事はこちらから⬇️ ow.ly/8MgP50QBwFW
1
12
45
4,658
Load more