On regeneration, ageing and the control of cellular plasticity
Also @maxyunlab.bsky.social
Joined November 2021
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Check out our latest preprint, where we show that adaptive immunity is dispensable for appendage regeneration in super regenerators, axolotl & zebrafish! : biorxiv.org/content/10.64898… thanks to Lizbeth, all authors and our collab Knopf lab
TheYunLab retweeted
The Chinese government is ramping up its support for science
go.nature.com/4lsG479
Check out our latest paper in press: pubmed.ncbi.nlm.nih.gov/4168… 💪🏻
This study provides new insights into axolotl age resilience and offers a model for understanding how long-lived vertebrates maintain reproductive capacity through 🕰️
Remarkably, they preserve early stage oocytes until advance ages, with old females spawning large numbers of viable larvae within the average lifespan. Interestingly they show follicular atresia concomitant with enlargement of egg size in late ages, likely a resilience strategy
This exciting work examines thousands of reproductive records for axolotls over 15 years (Tanaka & Yun labs). We show that egg number, quality and mating success rates peak after sexual maturation and stabilise after the early life period.
New Year, New Paper for the Yun Lab! 🌟We find that Axolotls exhibit limited reproductive senescence and retain fertility throughout lifespan (pubmed.ncbi.nlm.nih.gov/4168…). Kudos to Yuliia Haluza, in this great collab with @Tanaxolotl
First time in India, great science, food and friends.
#CMMDR26 has begun!✨
The Conference on Molecular Mechanisms in Development & Regeneration (6–9 Jan), opened with remarks by Dr Sanjeev Galande and a great first talk by Dr Maximina Yun on salamander models of #regeneration & aging.
Stay tuned!
#DevelopmentalBiology
TheYunLab retweeted
Research we covered in our #ARDD2025 field notes (linked below) is now published.
@MaxYunLab showed axolotls can regenerate their thymus de novo after complete removal. Not partial regrowth from remnants like mammals can often manage, but full reconstruction.
FOXN1, the transcription factor mammals need for thymus development, turns out to be dispensable for axolotl thymus regeneration. Midkine signaling appears to drive it instead.
This is relevant for longevity because in mammals, the thymus shrinks with age, taking T cell production and immune function with it. Axolotls skip this process entirely, maintaining their thymus throughout life with roughly flat mortality risk.
Understanding how they pull that off could eventually point toward ways to restore thymic function in aging humans.
TheYunLab retweeted
The growth factor #midkine, but not the transcription factor Foxn1, may drive #thymus regeneration following complete removal of the organ in juvenile axolotls.
Learn more in Science #Immunology: scim.ag/4pih6Zw
TheYunLab retweeted
Very proud of organizing the EMBO Regeneration Workshop 2026 in Krems, in the heart of Austria, together with @simoesfili, Anna Jazwinska, @solana_jordi, Mansi Srivastava, @MaxYunLab and Juanma González-Rosa! #EMBORegeneration Registration is now open!
meetings.embo.org/event/26-t…
Thanks to @ScienceMagazine for featuring our work: science.org/topic/article-ty… kudos to Christie Wilcox. @MaehrLab
Surprisingly, Foxn1 (key for thymus development and homeostasis in mammals) is NOT required for de novo regeneration: crispant foxn1-/- axolotls regenerate their thymus
