
Associate Professor, Purdue University (via India - U. Maryland, College Park - UCLA - UCSD/HHMI). Having fun following Fic proteins. @mattoolab.bsky.social
United States
Joined August 2018
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Dr. Seema Mattoo retweeted
🗳️Results of the 2025 ASBMB election are in!
☑️Please join us in congratulating our new president, secretary, Council members and committee members.
ow.ly/biaV50WgiA8
Dr. Seema Mattoo retweeted
Out Now! Host AAA-ATPase VCP/p97 lyses ubiquitinated intracellular bacteria as an innate antimicrobial defence bit.ly/4jebHzK #Microbiology #Antimicrobial #Bacteria
Dr. Seema Mattoo retweeted
We are delighted to welcome Joseph Mougous to the Microbial Sciences Institute. An international leader in microbiology and HHMI Investigator, Mougous joins the faculty @YaleMicroPath later this year. medicine.yale.edu/news-artic…
Dr. Seema Mattoo retweeted
This #InternationalWomensDay and everyday, we celebrate the inspiring women in our HF community who continue to push boundaries and shape a brighter future for science.💫
Dr. Seema Mattoo retweeted
The God of War joins the innate immunity lexicon. ARIES Domains: Multi-motif interferon (IFN) inducing signaling domains found in all known IFN-inducing pathways.
febs.onlinelibrary.wiley.com…
Dr. Seema Mattoo retweeted
It's Valentine's Day and Professor Tony Hunter has been "going steady" with Salk for 50 years now.
On Feb 21, join us in celebrating his half-century legacy at the Salk Institute. Lab alumni, colleagues, and other luminaries will share their science, memories, and tributes to this legendary cancer biologist.
Learn more about Hunter's remarkable legacy: salk.edu/news-release/celebr…
Dr. Seema Mattoo retweeted
I am thrilled to say that our work is now online @CellCellPress ! I've analysed protein structures for quite some time, but @Robb_Mallik, who co-led this work, took these analyses to yet another level - 🧵👇
sciencedirect.com/science/ar…
🔥Cell biology meets structuromics🔥 1000s of proteins assemble co-translationally but we don't know why🤷♂️ @Robb_Mallik found it’s all about protein 🧩structure🧩, with implications for #gene_expression, #proteostasis, #evolution & #mRNAlocalization 🧵👇
biorxiv.org/content/10.1101/…
Dr. Seema Mattoo retweeted
Is this real, or is it excessive AI hype? New paper claims that an AI foundation model achieves experimental-level accuracy in predicting gene expression even in previously unseen cell types." I'll read the paper, but don't believe it for a second
nature.com/articles/s41586-0…
Dr. Seema Mattoo retweeted
“Future scientific innovation requires the transformative power of philanthropy.” We're honored to be mentioned in this PNAS editorial as an example of philanthropy's role in supporting the next great scientific breakthroughs.
pnas.org/doi/10.1073/pnas.24…
Dr. Seema Mattoo retweeted
I'm so thrilled to (re)join the team @scifri. Ira gave me my first gig in journalism 20 years ago‼️ So this feels like a homecoming. It also feels like a really good time to be focused on bringing people trustworthy (and fun) science news.
We’re proud to announce that @flichtman is joining @iraflatow as a host of Science Friday!
sciencefriday.com/articles/f…
Dr. Seema Mattoo retweeted
🙏🙏🙏Honored and humbled. Huge Congratulations to @Bio_BRU and a big thank you to @sistonheat for all her hard work. Looking forward to the exciting journey ahead!
Thrilled to announce Dr. Mehdi Mollapour @MedMol as our new CSSI President (2025–2026) and Dr. Adrienne Edkins @Bio_BRU as President-Elect (2027–2028)! Huge thanks to Dr. Lea Sistonen @sistonheat for her dedicated service as Immediate Past President. bit.ly/4gCGEfB
Dr. Seema Mattoo retweeted
Thrilled to announce Dr. Mehdi Mollapour @MedMol as our new CSSI President (2025–2026) and Dr. Adrienne Edkins @Bio_BRU as President-Elect (2027–2028)! Huge thanks to Dr. Lea Sistonen @sistonheat for her dedicated service as Immediate Past President. bit.ly/4gCGEfB
Dr. Seema Mattoo retweeted
It was spring 2020. I was a professor and had recently learned I’d successfully been awarded early tenure. At the tail end of a series of talks at other universities, a colleague had invited me to give a seminar at a stellar department that was an unusually great fit for my research - they were interested in recruiting me there. I was about to fly there a second time with my husband to more carefully consider moving my lab, husband, and then-6yo son to a place they’d never been.
Two days before our trip, COVID shut down the country.
I remember thinking, “am I really going to leave my perfect stable life where my family is happy…to move to a place I know so little about, to a house sight unseen, to a department I just visited for the first time ever?”
The thing I remember most clearly from that time is the email I wrote to my new department chair. I said that every time I wonder if I’m crazy to take this leap, I remember how my parents moved to this country when I was 5 and my sister was 7. They left a comfortable life to a place where none of their professional credentials were recognized. My dad was the chief engineer on an oil tanker and retrained here as a software engineer, rose up in the ranks, and became senior manager in a lucrative tech company. My mom was a dentist who had to repeat 4 years of dental school entirely over in the states so she could do the work she already had infinitely more professional experience in than her classmates. Due to exchange rates and fees, any money set aside was decimated, and they started basically from scratch as they built up the skills to build a new life. All for the promise of uncapped potential for their kids. The decision I was grappling with in the aggressive safety of my life was a drop in the bucket of the leap of faith my fearless parents took for their kids.
So when offered the position, I told my new department chair that by comparison, this felt easy - I accepted the offer without reservation.
While I didn’t stay there long, I soon co-founded a company that employs even more people than my academic lab did, working on some of the most important problems at the leading edge of biotechnology.
I feel so fortunate this country welcomes intellectuals and founders but also all those whose potential we cannot predict to create what we cannot imagine.
America is the promise of what is not yet realized. Built by those who are not yet famous. The unique mix of creativity and talent and ambition and fearlessness from every corner of the world. It’s such a humbling and awe-inspiring idea we have the opportunity to fight for.
Dr. Seema Mattoo retweeted
Excited to share our latest study in @PLOSGenetics "Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity". Thanks to lab members @psiddhi273 @megan_mitchem and Courtney Shrader for their hard work 🔥journals.plos.org/plosgeneti…
Dr. Seema Mattoo retweeted
Our❄️December❄️issue is live!
Depicted on the cover - how #sHSPs 'catch' non-native proteins to protect the proteome. Read the Review "Catchers of folding gone awry: a tale of small heat shock proteins" from @buchnerlab_tum and colleagues.
Find it here: cell.com/trends/biochemical-…
Dr. Seema Mattoo retweeted
Hear from PAGER’s co-creators, @nkalogriopoulos and @ReikaTei in this Stanford news story from @Taylor_Kubota:
Tool that enhances control of cellular activity could expand biological and medical frontiers
news.stanford.edu/stories/20…
Dr. Seema Mattoo retweeted
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time fluorescence to modulation of innate cell behavior (excitation or inhibition of neurons, induction of cell migration, etc.)?
Today we report in Nature a new technology platform that provides a step in that direction: PAGERs, for Programmable Antigen-gated G protein-coupled Engineered Receptors, convert recognition of extracellular soluble or cell-attached antigens into diverse user-selected responses. PAGERs are based on G-protein coupled receptors (GPCRs), which themselves are not structurally modular, but we were able to build in modular antigen gating by fusing an antagonist peptide to the extracellular N-terminal end, and then gating the antagonist with a fused antigen-binding nanobody. When antigen binds, it sterically interferes with the antagonist, leading to relief of receptor inhibition. Drug or agonist can then turn on PAGER.
nature.com/articles/s41586-0…
Dr. Seema Mattoo retweeted
Bactericidal antibiotics release DNA that activates TLR9, while static antibiotics do not. Can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics?
Amazing work by Julia Gross and collaboration with Iain Fraser!
nature.com/articles/s41467-0…
Dr. Seema Mattoo retweeted
Do you need an intro to analyzing (prote)omics data?
This series of lectures may be helpful.
We aimed to make them short & accessible.
Enjoy watching & learning!
youtube.com/playlist?list=PL…
Dr. Seema Mattoo retweeted
Honored for our lab to be included in the #HighlyCited2024 list by @Clarivate
This recognition is a testament to the outstanding scientists I am lucky to work with every day.
@BostonChildrens @harvardmed
xitter.cf/ClarivateAG/status/185…
IT’S HERE! The Highly Cited Researchers 2024 list has now been published. #HighlyCited2024
Discover the world’s influential #researchers: clarivate.com/news/clarivate…



























