Biophysicist | #Postviral syndromes, #longCOVID, #PACVS | Open Source Medicine Foundation | https://xitter.cf/t.co/kWFDPz3ED2
Joined October 2022
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The spike protein is typically gone in weeks. So why do some patients stay sick for years?
Prof. Paolo Bellavite’s hypothesis: the antibodies outlast the spike. Anti-spike antibodies may lead to anti-ACE2 antibodies that block ACE2, raising angiotensin II and bradykinin.
youtu.be/6k9d3APytpw
#PACVS #ACE2
Matthew Halma retweeted
Join the Open Source Medicine Foundation for a live discussion with Michelle Worton and Julie Woods, co-founders of CANrise19. @michelleworton @CANrise19Org
We explore the grassroots movement providing peer support to Canadian patients, the significance of recent milestones like the Allison Inquiry, and the vital pathways needed for acknowledgement, treatment, research, and compensation.
Date: Tuesday, October 27, 20261
Time: 10:00–11:00 AM MT / 12:00–1:00 PM ET1
xitter.cf/i/broadcasts/1RKZzBMVW…
Matthew Halma retweeted
The people protecting the Epstein Pedo’s are now blaming a 12 YEAR OLD GIRL for being Raped by her stepfather & abused by her mother who sided with the rapist.
What exactly do they think they’re doing her?
They just accidentally revealed who they really are- psychopaths hungry for power:
Matthew Halma retweeted
Note that the Magic Clinic in Calgary and Mitrix are doing a MELAS/MILS/MERFF trial, using a simple form of mitochondrial transplantation to reduce the severity of the infections (sepsis, pneumonia, influenza) that frequently endanger these patients.
mitrix.bio/wp-content/upload…
@MitoPsychoBio @MitoCanada @UMDF @BillAckman @JeffBezos @Mito_Therapy @ClevelandClinic @ChildrensPhila @PolGFoundation @BillGates @SecKennedy
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Matthew Halma retweeted
The GOP chose to lose Ohio. I can’t imagine any candidate, except Vivek, having so few scruples that they pay the woman who facilitated her daughter’s continual rape, to be the face of a campaign ad.
BOMBSHELL:
Ohio Democratic gubernatorial candidate Amy Acton’s own mother urges voters not to vote for her daughter.
“My name is Donna Arthur and I’m Amy Acton’s mother. I worked at Children and Family Service Association, building one of the first two sexual abuse programs in America.
I love my daughter, but when I saw her lying about her opponent—and it’s not easy for a mother to say this—but Amy has a serious problem.
She is a liar. She lies about her past. She says she grew up living in a tent. None of that is true. She’s lied her entire life.
My daughter needs help, and she can’t help you if she needs help herself. People can change, but first they have to tell the truth, and my daughter still isn’t doing that.
Don’t vote for people who lie. Don’t let her become your governor. If you think she’ll make your life better, you’re fooling yourself. It will only get worse.”
That’s one hell of an October surprise.
Readers added context they thought people might want to know
Acton's mother lost custody of her children after years of documented issues, including time spent living in a tent and a spouse who sexually abused her daughter Amy (Acton). Amy Acton's brother has also confirmed this story.
x.com/amyactonoh/sta…
wkbn.com/news/local-new…
time.com/collections/co…
vindyarchives.com/news/2019/aug/…
614now.com/2020/culture/c… actonforgovernor.com/meet-amy/
Matthew Halma retweeted
Flabbergasted that Vivek Ramaswamy, down in the polls and almost certain to lose a state Trump won by +11 points, thought he could clutch victory from the jaws of defeat by getting his opponent’s estranged mother, who stayed with the man who raped her when she was twelve, to badmouth her as a liar in campaign ads just before the election. This is Ramaswamy’s ace in the hole, his Hail Mary.
Ramaswamy has no sense for decorum, no theory of mind for the average voter, and it is this total lack of grace and sensitivity that led him to thoughtlessly excoriate American workers as sluggish and replaceable two Christmases ago, thinking it would play well with the base.
Other politicians might have contempt for their constituents, but they know not to broadcast this fact, to keep it somewhat under wraps. Ramaswamy still has no idea why he is losing.
One protein, many shapes, and each technique sees a different slice.
What if you saw them side by side?
Introducing Conformome: a new resource gathering experimental evidence on protein conformations from many techniques, mapped onto shared states.
conformome.org/
Current pilot numbers:
• 83 molecules (81 proteins, 1 RNA, 1 DNA)
• 17,549 evidence entries
• 20 techniques
• 9 sources
• 71 draft-curated states
Sources include RCSB PDB, BMRB, AlphaFold DB, SMASH-BIO (force spectroscopy), DisProt, MDDB, SASBDB and others.
Why it matters: roughly 85% of human proteins are estimated to be “undruggable” by classic small molecules.
Many lack deep pockets, act through flat protein–protein interfaces, or are highly dynamic or disordered.
Conformations can open that space. Other states can expose cryptic pockets, allosteric sites or interfaces one static structure hides.
Check it out at conformome.org/ — better maps of conformational states can expand the set of targets we can meaningfully pursue in drug discovery.
Halma MTJ, Tuszynski JA, Wuite GJL. Optical tweezers for drug discovery. Drug Discov Today. 2023;28(1):103443. doi.org/10.1016/j.drudis.202…
Matthew Halma retweeted
NEW - NIH stands behind vaccine injury research announcement; provides more details.
nih.gov/about-nih/nih-direct…
Here is React19's take:
Mice given repeated mRNA-1273 shots made anti-ACE2 antibodies that rose with each boost and were still there 3 months later.
Levels were lower in the human-ACE2 mice than in normal mice, which the authors read as binding to human ACE2.
Why some people, and why so long?
Suspects: genes (HLA, MTHFR), lipid nanoparticles, impurities, mimicry. Bellavite argues autoantibodies outlast spike, though spike has been seen 180 days out.
n=17, no controls: a lead, not proof.
Research discussion, not medical advice.
Put these two references in a single reply under it, 237 characters:
Mantovani M, Bellavite P, et al. Biomedicines. 2024;12:2852. doi.org
Jerne NK. Ann Immunol (Paris). 1974;125C:373-89. pubmed.ncbi.nlm.nih.gov
Other links in the paper:
Anti-MAS1 higher with widespread burning sensations
Anti-STAB1 with skin swelling or rash
Anti-ATR1 with swollen glands or tonsillitis (only 2 positive)
Anti-CHRM3 trended toward fewer symptoms.
In his model, if these antibodies block ACE2, angiotensin II and bradykinin build up.
That could mean high blood pressure, inflammation and vessel-lining damage. Anti-MAS1 could block the protective angiotensin 1-7 arm.
Bellavite P. Lecture on autoantibodies in post-acute COVID vaccination syndrome [video]. Posted by Matthew Halma on X. xitter.cf/MatthewHalma/status/21…
What role do autoantibodies have in Post-Acute COVID-19 Vaccination Syndrome?
An invited lecture by Prof. Paolo Bellavite, MD, formerly Professor of General Pathology at the University of Verona. @BellavitePaolo
He covers GPCR autoantibodies, disruption of the renin-angiotensin system, and the immunopathology behind Post-Acute COVID Vaccination Syndrome (PACVS). The talk goes from retrospective case series to mechanistic frameworks.
Watch (36 min): youtu.be/_F2fb9lfcHI
Ref: Mantovani, Bellavite et al., Biomedicines 2024;12(12):2852
PACVSResearchSummit.com
The study: 17 patients at a Milan clinic with post-vaccine symptoms (PACVS).
13 women, 4 men, mean age 44
15 had mRNA vaccines, 2 AstraZeneca
Symptoms for a median of 20 months (range 4–32)
No sign of prior COVID: anti-nucleocapsid negative in all
14 of 17 healthy beforehand
Anti-ACE2 stood out.
Across 19 symptoms, anti-ACE2-positive patients had 4x the odds of having more symptoms (OR 4.00, 95% CI 1.88–8.51).
All 8 patients with bruising, skin swelling or rash were anti-ACE2 positive, vs 3 of 9 without (p=0.009).
Ref Mantovani M, Bellavite P, Fazio S, Di Fede G, Tomasi M, Belli D, et al. Autoantibodies targeting G-protein-coupled receptors and RAS-related molecules in post-acute COVID vaccination syndrome: a retrospective case series study. Biomedicines. 2024;12(12):2852. doi.org/10.3390/biomedicines…
They tested 16 autoantibodies: 14 against G-protein-coupled receptors, plus ACE2 and STAB1.
Positive:
MAS1 16/17
ACE2 11/17
CHRM4 10/17
ADRA1A, ADRB2 9/17 each
Classic autoimmune markers (ANA, ENA, ANCA) were negative in all 15 tested.
Why do some people stay unwell for months after a COVID vaccine?
Prof. Paolo Bellavite (formerly Univ. of Verona) argues autoantibodies against receptors that steer blood vessels, heart rate and nerves may be central.
His talk + the study behind it 🧵
xitter.cf/MatthewHalma/status/21…
What role do autoantibodies have in Post-Acute COVID-19 Vaccination Syndrome?
An invited lecture by Prof. Paolo Bellavite, MD, formerly Professor of General Pathology at the University of Verona. @BellavitePaolo
He covers GPCR autoantibodies, disruption of the renin-angiotensin system, and the immunopathology behind Post-Acute COVID Vaccination Syndrome (PACVS). The talk goes from retrospective case series to mechanistic frameworks.
Watch (36 min): youtu.be/_F2fb9lfcHI
Ref: Mantovani, Bellavite et al., Biomedicines 2024;12(12):2852
PACVSResearchSummit.com
First, the system involved: the renin-angiotensin system (RAS).
One arm (ACE, angiotensin II, AT1) tightens vessels and drives inflammation.
The other (ACE2, angiotensin 1-7, MAS1) relaxes vessels and calms inflammation.
ACE2 is also the spike protein's receptor.
Bellavite P. Lecture on autoantibodies in post-acute COVID vaccination syndrome [video]. Posted by Matthew Halma on X. xitter.cf/MatthewHalma/status/21…
What role do autoantibodies have in Post-Acute COVID-19 Vaccination Syndrome?
An invited lecture by Prof. Paolo Bellavite, MD, formerly Professor of General Pathology at the University of Verona. @BellavitePaolo
He covers GPCR autoantibodies, disruption of the renin-angiotensin system, and the immunopathology behind Post-Acute COVID Vaccination Syndrome (PACVS). The talk goes from retrospective case series to mechanistic frameworks.
Watch (36 min): youtu.be/_F2fb9lfcHI
Ref: Mantovani, Bellavite et al., Biomedicines 2024;12(12):2852
PACVSResearchSummit.com