An unexpected and potentially big finding: A single mitochondrial protein has an outsized role, acting as a central node, coordinating our circadian clock, temperature, dietary cues, sleep/wake cycle to control brown fat metabolism @ScienceMagazine science.org/doi/10.1126/scie…

NASA Is About to Investigate What Lies Beneath a Giant Hole on the Moon scitechdaily.com/nasa-is-abo…

A Billion Tons of Lunar Water Cannot Sustain a Moon City, Study Finds bioengineer.org/a-billion-to…

MIT engineers have developed a new way to program natural killer (NK) immune cells to target cancerous T cells or T cells that have become autoreactive, leading to diseases such as lymphoma and autoimmune hepatitis. news.mit.edu/2026/reprogramm…

Nothing is free in biology. Everything we do costs energy. Our overall energy needs are influenced by how our mitochondria transform energy. But when mitochondria are defective or flow energy with excessive energy resistance, what happens to the energetic costs of life as we go through our daily rhythms? Do people burn more energy, less energy, or somehow compensate? A new paper, led by Evan Shaulson in our group, revealed interesting connections between mitochondria, energy, and behavior.

Peter Thiel has been saying for over a decade that America no longer believes it can beat Alzheimer's. Last year he said the field was "completely stuck on beta amyloids." Eli Lilly CEO @DaveARicks tells @BiotechTV that Kisunla, its amyloid drug, would be called a giant if it were a cancer drug. Read the two side by side and they end up in the same place. Thiel wants the field to "take way more risk." Ricks wants "more assets, more resources." Both think neurology has been aiming too low. The other bottleneck has been diagnosis. Confirming Alzheimer's used to take a PET scan or a spinal tap, and the FDA has now cleared blood tests for it, most recently in August. "Kisunla, which was like our sixth, seventh or eighth molecule we tried to get to work in amyloid targeted therapies... my entire career we've been working on this and mostly not successful... if we put this in like cancer terms, I mean the hazard ratio in that study is like 0.68, 0.67. If that was a new cancer drug, forget any other kind, you'd be like, this is a giant drug. And so it's slowing a fatal disease. Alzheimer's is 100% fatal, with that hazard ratio, it's a little surprising to me neurology hasn't stood up and said, we need more assets, more resources. A lot of the reason people don't get it today at scale is testing and workup."

Proud to announce 4% "young" mitochondria transplanted safely into "old" mice, producing significant, measurable signs of age reversal and physical improvement. -- Over the past 3 years Mitrix has done numerous large transplants of young mitochondria into old mice, demonstrating among other things, regeneration of the hippocampus of the brain and dramatic improvements in survival from bacterial and viral infections. lnkd.in/gDXT6zvK We've also announced major milestones achieved in the use of our Mitochondrial Bioreactor. lnkd.in/gx3nvXax Now we've optimized the injection process to achieve an unprecedented, massive number, approximately 4% upgrade of the mitochondria in a cohort of mice, injected over 6 months in many transfusions. The approximately 18-month-old mice are healthy and robust, showing significant signs of age-reversal including faster wheel running time and reduced body weight. These experiments are still very preliminary and there is much testing and replication yet to do. We have not yet performed tests to confirm the total % of these transplanted mitochondria that have successfully engrafted in the cells of the body...although from past experiments by many other researchers, we suspect that the % permanently engrafted could be very large. We believe that this 4% mitochondrial transplant is by far, the largest acheived for any animal in the history of science. These mice will continue recieiving mitochondrial transplants until they achieve a 10% supplementation level.. and maybe beyond. --- Based on the latest research, both stem cells and platelet rich plasma (PRP) act as mitochondrial "donors" Therefore we estimate that the 4% transplant of mitochondria is roughly equivalent, in terms of age reversal, to 4000 stem cell treatments or 100,000 Platelet Rich Plasma treatments (if we adjust all numbers for human size and weight). More data will be released in the future, along with more published papers. (Disclaimer: this concept has not been tested in human patients, is not approved by any regulatory body, and is not yet in human trials. Any statements above are speculative.)

When an older heart is transplanted into a younger person, it doesn't stay "old." Vadim Gladyshev's lab shows the heart actually starts aging on the timeline of the body it's now living in — its biological age shifts to match the recipient, not the original donor, at the molecular level. biorxiv.org/content/10.64898…