@MartinLabMIT

Associate Professor @MITBiology. Interested in how cells generate force and how they work together to sculpt tissues.

 Cambridge, MA
web.mit.edu/martin-lab/
Joined July 2019
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  • Following273
  • Followers1.3K
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Watch the movies while reading our newest. Great work from Jasmin Imran Alsous, with @NicolasRomeo17, Jonathan Jackson, and @frank_m_mason. Another great collaboration with Jörn Dunkel's group who provide the critical connection to balloons. @MITBiology pnas.org/content/118/10/e201…
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Check out this excellent profile of Professor of Chemistry and @MITBiology Catherine Drennan (@Drennan_Lab) recently published in @PNASNews! pnas.org/doi/10.1073/pnas.24…
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Join us at the 2025 Cell Contact and Adhesion @GordonConf. Great people and great science!
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Pleased to share the publication of our paper showing the role of EGFR in coordinating morphogenetic movements in Developmental Cell. Congratulations @MITBiology postdoc, @natclarke8 for all your hard work! Article: pubmed.ncbi.nlm.nih.gov/3946…
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These cell adhesion complexes serve as a scaffold to recruit actomyosin through patterned mechanical feedback. Thus, EGFR + mechanical pull recruits actomyosin. Work from @StreichanS demonstrated this patterned feedback and we showed that it is linked to EGFR.
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Thus, we showed a relay system that doesn’t just result in a wave of the same shape change, but a trigger mechanism for one mode of morphogenetic change jump-starting another.
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Online now: Postdoc Nat Clarke's @natclarke8 excellent work on a mechanism that coordinates tissue folding and axis extension. Great job and congratulations Nat!
Developmental Cell@Dev_Cell25 Oct 2024
Online now: EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster dlvr.it/TFkc2d
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IMO in career decisions, too many people optimize for what they think they’re entitled to when instead, opting into cool shit and proving themselves will often result in way better outcomes than they expected in the first place
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I am incredibly excited and honored to be running for the Secretary position for the Society of Developmental Biology! If you are a member, I would appreciate your support and your vote. I'd love the opportunity to serve our community in this way. Thanks!! Plz RT!
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So much successful science involves people behind the scenes making the jobs of faculty, students, and postdocs possible. They don't often get the recognition they deserve, but are truly appreciated by those they support. Great job John Fucillo, you are a pleasure to work with!
MIT Biology@MITBiology2 May 2024
Building 68 manager John Fucillo’s leadership, innovation, and laid-back attitude have built a community culture that will never be taken for granted. #staffspotlight biology.mit.edu/staff-spotli…

Staff Spotlight: John Fucillo, Building 68 Manager, EHS Coordinator; Chemical Hygiene Officer - MIT...

Building 68 manager John Fucillo’s leadership, innovation, and laid-back attitude have built a community culture that will never be taken for granted.  When entering the office of Building 68’s...

biology.mit.edu
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Congrats to @natclarke8 and Uzuki Horo for their study being highlighted by @ASCBiology.
American Society for Cell Biology@ASCBiology29 Apr 2024
FROM MBoC This study unravels the complex dance of the cytoskeleton during Drosophila gastrulation, revealing how Fog/Cta & T48 pathways uniquely & collectively guide early embryo development. molbiolcell.org/doi/10.1091/… @mShaneHutson @MIT @MartinLabMIT
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Excited to have submitted manuscript by @MITBiology @urop_mit Uzuki Horo. @natclarke8 mentored Uzuki and pushed the project to completion. We discovered how Fog and T48 pathways distinctly regulate myosin activation. biorxiv.org/content/10.1101/…
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Not to be outdone, T48 mutants also had distinct effects. While affecting myosin accumulation in tissue folding, T48 mutants also affected earlier stages of development, exhibiting defects in cellularization and egg shape. Consistent with this, T48 is maternally deposited.
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Overall, we showed that the Fog/Cta and T48 pathways have overlapping and distinct roles in the development of the Drosophila embryo. These pathways regulate RhoA and so this informs on potential signaling logic for the RhoA pathway in other systems.
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Adam Martin retweeted
MIT Science@ScienceMIT22 Jan 2024
According to Jay Stein PhD ’68, the Jay A. Stein (1968) Professorship of Biology at MIT "is a way to pass the baton of science, from one generation to the next—hopefully, forever." science.mit.edu/passing-the-…
Amy Keating stands smiling beside Jay A. Stein, who is seated in a biology laboratory.

ALT Amy Keating stands smiling beside Jay A. Stein, who is seated in a biology laboratory.

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"The cytoskeleton is boring". Ironically, I also started grad school with the thought that I would NEVER work on the cytoskeleton.
Iain Cheeseman@iaincheeseman19 Jan 2024
Cell biology is .... truly awesome. My take on what cell biology means to me in the latest issue of @CellCellPress celebrating their 50 years. I really enjoyed reading the pieces from everyone. authors.elsevier.com/c/1iS4a…
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Here is an open link to: Basic Science is not just a Foundation. (Nature Cell Biology, Volume 26, pages 8–10 (2024): rdcu.be/dv82R
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I am hiring in 2024. Contact me if you'd like to learn about my lab and the NIH
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Pierre Ronceray and I are recruiting a PhD student to study non-equilibrium fluctuations in developing fly embryos. The position is through @centuri_ls in Marseille, France and will begin in October 2024. Applications due Feb 15th. More details here: centuri-livingsystems.org/ph…. #phd
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