Rising M4 MD/PhD Candidate @PennStHershey | Applying #RadOnc for 2027 Match | Alum @ASU @Cambridge_Uni | Bridging GWAS & multi-omics with clinical oncology 🧬
Hershey, Pennsylvania’s
Joined August 2019
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Excited to share a part of my PhD thesis! We developed a novel method to predict the risk of progression from pre-clinical to clinical disease for SLE and RA. So thankful to my co-first author @ChenWang_PSU and mentors @dajiangliu81 and Dr. Bibo Jiang
I am happy to share our new work that predicts the progression of autoimmune diseases, integrating EHR and GWAS datasets @NatureComms . nature.com/articles/s41467-0…
Havell Markus retweeted
Don't throw away FNA supernatants... they can be used for rapid molecular testing!
Would your lab consider testing supernatants?
@Biocartis_
@CancerCytopath @bfaquin
#OpenAccess! Ultrarapid BRAF mutation detection on supernatant cell-free DNA obtained by FNA: An accurate and expedient method for BRAF assessment in aggressive thyroid carcinomas
acsjournals.onlinelibrary.wi…
#CytoPath @carliesigel
Havell Markus retweeted
In a new Science study, researchers present the Virtual Biotech, a multi-agent AI system to inform drug-development decisions.
By combining diverse biomedical and clinical evidence in a unified platform, the system may help identify therapeutic opportunities that would otherwise be missed.
Learn more: scim.ag/46WEiVK
Havell Markus retweeted
Good food, great company and fresh ideas! Radiation Oncology faculty and staff gathered for lunch at ASTRO 2026 to connect and share what they’ve learned about opportunities to advance patient care.
Havell Markus retweeted
Excited to introduce uRARE-Seq for detection and monitoring of bladder cancers and beyond.
Eager to see how this new liquid biopsy tool can change the course of these diseases and overcome the unmet needs of patients with these challenging genitourinary cancers.
@Kevinjliu_ @max_diehn @StanfordMed @StanfordCancer @stanfordcbio
nature.com/articles/s41591-0…
Thank you so much, Dr. Tchelebi! This means a lot coming from you. My first #ASTRO2026 was an incredible experience, and I am so grateful to my research mentor @VinitaTakiar and the @PennStHershey #RadOnc family for their support. 🙏
Incredibly proud of rockstar @PennStHershey 4th year medical student @MarkusHavell for his presentation on #GLP1 agonists as radioprotectors at #ASTRO2026. Jealous of the #RadOnc residency program who will get the privilege to train him! @VinitaTakiar @PSH_CocoaBeams
Havell Markus retweeted
What did ASCO 2026 change?
Some standards of care have now moved by years.
That almost never happens.
BRAF colorectal, pancreatic KRAS, and DDLPS sarcoma
are three of oncology's hardest diseases
SOC moved by > 1yr:
▫️BRAF mCRC: 15.1 → 30.3 months OS
▪️Pancreatic KRAS: 6.7 → 13.2 months OS 🏆
▪️DDLPS sarcoma: 1.5 → 9.7 months PFS ⭐️
(sarcoma went from "nothing" to a win).
Myeloma, GIST, HR+/HER2- breast, uveal melanoma, bladder, prostate, and RET+ lung cancer moved too.
This is what decades of funded science look like when it compounds.
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Source: Jori (@jori_health)
𝘗𝘭𝘰𝘵 𝘱𝘦𝘦𝘳-𝘳𝘦𝘷𝘪𝘦𝘸𝘦𝘥 𝘣𝘺 𝘦𝘪𝘨𝘩𝘵 𝘰𝘯𝘤𝘰𝘭𝘰𝘨𝘺 𝘦𝘹𝘱𝘦𝘳𝘵𝘴. 𝘛𝘩𝘢𝘯𝘬 𝘺𝘰𝘶 <3
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Havell Markus retweeted
Excited to share our new paper investigating the role of a generalised autoimmunity polygenic risk score on cessation of immune checkpoint inhibitor therapy for toxicities. @rohit_thum @ziv_elad @AdamJSchoenfeld @MelindaAldrich @christine_lovly @UCSFCancer @UCSFMedicine
New #JITC article: Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events bit.ly/3E3NkoX @PoojaMiddha21 @AdamJSchoenfeld @rohit_thum @pmcancercentre @MattGubensMD
@christine_lovly @MSKCancerCenter @VUMC_Cancer
Havell Markus retweeted
A massive @ScienceAdvances study involving weekly data from more than 300,000 pregnancies offers a new look at dynamic physiological changes and complications. scim.ag/4jdEtA1
I'm excited to share a wonderful collaboration with @LD_matrix: JOBS integrates bulk and single-cell eQTLs to boost eQTL discovery. Integrated with GWAS, it identified more disease-linked loci for 14 immune disorders & fueled drug-repurposing. #immunology #drugdiscovery #genomics
Havell Markus retweeted
I am excited to share our new work that generates a single cell eQTL atlas for immune cell types. The work integrates bulk eQTLs with sc-eQTLs, which boosts the power for identifying sc-eQTLs for up to 4 folds. As such, we have the power equivalent to sc-RNASeq of 4K individuals.
An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment dlvr.it/TJnSg0
Havell Markus retweeted
Thrilled to share new work led by @JieYang437 in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
Havell Markus retweeted
Super excited to share our most recent work! Heart transplant rejection was a new area for me, but it's a disease I care deeply about. As some of you know my dad passed unexpectedly from heart failure in Oct. 2020 only a few days after he was informed he needed a transplant.
I am excited to share our most recent work using spatial transcriptomics to uncover dynamic molecular responses to rejection in transplanted human hearts! 1/15
biorxiv.org/content/10.1101/…
Havell Markus retweeted
So exciting to see that PathChat published in @Nature last summer (nature.com/articles/s41586-0…) has now received FDA Breakthrough Device Designation. Likely one of the first generative AI tools for pathology to receive the designation. We are well on our quest to having a single MLLM answer any question about human pathology! Congratulations to our superstars who worked on this project @richardjchen @MYLu97 @DFKW_
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Havell Markus retweeted
📢Blood DNA virome🧬🦠 assocites autoimmune diseases🔬. Endogeneous human herpesvirus 6B (eHHV-6B) has systemic lupus erythematosus (SLE) risk. Increased anellovirus in SLE, rheumatoid arthritis (RA), COVID-19 @NatureGenet📰#wgs #lupus #virus #covid #gwas
nature.com/articles/s41588-0…
Havell Markus retweeted
Excited to see this study published! Great work that was co-led my Niran Hadad from my group. cell.com/cell-reports-medici…
Havell Markus retweeted
Polygenic risk scores (PRS) are mostly trained on clinical endpoints. Remains unknown if they associate with subclinical pathologies🧬
This paper on Alzheimer's disease shows associations of a PRS with longitudinal imaging and memory changes🧠📉
📜: nature.com/articles/s41467-0…
