Mom-in-training, avid equestrian, happy hiker. Postdoc @uvmpharmacology studying cerebral blood flow and brain metabolism
Joined August 2012
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Maria Noterman retweeted
Want to actually understand mitochondria & metabolism?
Dr Jared Rutter, biochemist & HHMI investigator is a world class expert. You’ll learn mitochondria do far more than create energy for cells. Bonus: he weeds out a lot of nonsense you hear online about metabolism and energy.
The new Huberman Lab episode is out: How Mitochondria Control Your Metabolism | Dr. Jared Rutter (@rutterlab)
0:00 Jared Rutter
2:29 Metabolism, Cells; Aging
8:36 Mitochondria, Origin & Cell Complexity
13:07 Sponsors: Joovv & BetterHelp
15:16 Mitochondria Genome, Inheritance
18:18 Mitochondria & Spatial Distribution; Cell-Specific Metabolism
25:59 Nutrient Energy, Hormones, Fat Cells
31:13 Glucose, ATP Conversion, Pyruvate
36:41 Cell Choice: Energy or Growth, Cancer; Virus
46:02 Sponsors: AG1 & Eight Sleep
48:36 Microbiome, Role of Humans
51:44 Molecule Discovery Process, MPC1, MPC2
59:42 Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart
1:07:03 Cell Resource Allocation, MPC, Heart Failure; Disease
1:11:46 Sponsor: Function
1:13:24 Cell Size vs Fuel Balance, Cell Identity & Disease
1:20:43 MPC Discovery, Genetics, Model Systems
1:24:29 Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy
1:31:32 Cancer, Mutations, Metabolism Changes & Warburg Effect
1:36:18 Cancer Challenges & Therapies
1:43:00 Therapy Combinations, Unique Cancer Mutations & Metabolism
1:48:31 Technology to Visualize Metabolism; Disease, Metabolism & Scents
1:56:34 Excess Energy & Mitochondria, Reactive Oxygen Species
2:01:12 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
Includes paid partnerships.
Maria Noterman retweeted
Nature research paper: Cell-type-targeted mitochondrial transplantation rescues cell degeneration
go.nature.com/4mtpHb2
Maria Noterman retweeted
Energy metabolism is really quite remarkable
Little bits of energy we call metabolites flow continuously, converging in our mitochondria (TCA or Krebs cycle) where they are re-routed and directed where needed
The basis of life and health is the flow of energy
Great animation showing the fate, trajectory, and possible routes that glucose (top) and glutamine (bottom right) take within most of our cells
Video by @janetiwasa
Maria Noterman retweeted
NHLBI FY 2025 Funding and Operating Guidelines
@nih_nhlbi
nhlbi.nih.gov/current-operat…
Maria Noterman retweeted
🚨with keys in hand and days to count, the newly minted @bomba_lab is officially recruiting postdocs!! Check our lab website for details and ways to apply: bombawarczaklab.com/people/n… @mitojobs #teammassspec @PennMedicine @UPennPhysiology. Please share!
Thrilled to share that I will be starting as an Assistant Professor in the Department of Physiology at the University of Pennsylvania @UPennPhysiology @PennMedicine in January 2025!
Maria Noterman retweeted
Can we use CRISPR screens to identify genes that drive neural stem cell aging?
Super excited to see this work published @Nature!
Huge congrats to Tyson @ruetz_tyson, Angie Pogson, @kashiwagi_chloe, and all authors! Great collaboration with @MCBassik!
nature.com/articles/s41586-0…
Maria Noterman retweeted
This looks like a great opportunity!
Hey Postdocs - check out UTD's SOAR award - $1000 and $500 awards + invited lecture @BBSutdallas for research that is underrepresented in the field. Apps due August 19. More info here: bbs.utdallas.edu/research/op…
Maria Noterman retweeted
Proud of this paper. A direct follow-up to our @Cell_Metabolism paper. Could only have been done with the unique collab between @RutterLab, @StavrosDrakos, and @gsducker labs! Stay tuned for more papers in the pipeline… @HHMINEWS @UofUBiochem @NEH_CVRTI
Excited to share my postdoc work is published in @JCI_insight! This was the culmination of a lot of hard work from a lot of great researchers @NEH_CVRTI @UofUBiochem @RutterLab @StavrosDrakos @gsducker @molecularpepsi @ThirupuraShank1 @rana_hamouche
insight.jci.org/articles/vie…
Maria Noterman retweeted
Adenosine signalling to astrocytes coordinates brain metabolism and function
nature.com/articles/s41586-0…
Maria Noterman retweeted
REVIEW | Sharma, Khandelwal & Wolfrum (@ETH_en)
The authors review the regulation and biological functions of apparently ‘futile’ dynamic lipid cycle in regulating whole-body metabolic #homeostasis.
nature.com/articles/s42255-0…
Maria Noterman retweeted
Our latest @Nature paper is out! We show that transplanting mitochondria into endothelial cells boosts their ability to form blood vessels in ischemic tissues, with mitophagy as the key mechanism. A potential game-changer for vascular cell therapies. nature.com/articles/s41586-0…
Maria Noterman retweeted
I’ve handled the review of > 1000 papers at @nature. Over time, you notice aspects of presentation on which reviewers tend to comment. In the interests of minimizing hassles during review, I offer the following suggestions (a bit targeted to climate papers).
Maria Noterman retweeted
Presenting metabolomics analyses: what’s in a number?
As part of a methods advice series, Meiser and Frezza highlight frequent pitfalls and offers guidance related to designing, processing, and communicating metabolomics analyses
@JohannesMeiser @FrezzaLab
embopress.org/doi/full/10.10…
Maria Noterman retweeted
Oxygen fluctuates dramatically, even in the healthy mouse brain 🐁🧠| @PNASNews @NedergaardLab
pnas.org/post/journal-club/o…
Maria Noterman retweeted
For ~25 years Ad vectors had little to no ability to transduce Purkinje cells, until now! Excited to announce our paper in MTMCD @MolTherapy on the development of Ad vectors that transduce Purkinje cells in a humanized mouse model shorturl.at/wyBW5
Maria Noterman retweeted
Excited to be co-hosting our annual Spring #PD Symposium with the MN chapters of @ParkinsonDotOrg and @APDAParkinsons
There is still time to register! But space is limited for in person, so sign up soon!🌷
👇 – at Richfield, MN
To cap off #BrainAwarenessWeek we would like to invite you to our annual MN Spring PD Symposium!
Save the date: Wednesday April 24th, 10am-2pm
Come join us for a day of learning about PD and being in community!
Register at: tinyurl.com/MNSpringPD24
Program is free!
Maria Noterman retweeted
Online now! @katalin_volgyi , @Judit_GonzalezG et al., provide a #proteomic profile of the #aging brain endothelium identifying a dysregulation of proteins involved in vesicle-mediated transport pathways, most prominently Arf6. rdcu.be/dCnfU
Maria Noterman retweeted
How can you partition the frozen human brain to systematically profile mitochondrial OxPhos capacity and diversity?
Eugene Mosharov found a way to create physical brain voxels (3x3x3mm) and teamed with @MichelTdS to project results in standard MNI space.
Maria Noterman retweeted
Maternal Exercise Preserves Offspring Cardiovascular Health via Oxidative Regulation of the Ryanodine Receptor - ScienceDirect sciencedirect.com/science/ar…