@MarescaLab
 UMass Amherst
bio.umass.edu/biology/maresca/
Joined February 2013
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Proximity-based activation of AURORA A by MPS1 potentiates error correction biorxiv.org/cgi/content/shor… #biorxiv_cellbio
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Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes biorxiv.org/content/10.1101/…

Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in...

The reductional division of meiosis I requires the separation of chromosome pairs towards opposite poles. We have previously implicated the outer kinetochore protein SPC105R/KNL1 in driving meiosis I...

biorxiv.org
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Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!
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I am hiring in 2024. Contact me if you'd like to learn about my lab and the NIH
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Image shows characterization of cytosolic Spc105 oligomers. McGory et al. @MarescaLab @UMassAmherst uncover a linkage between the disordered kinetochore protein Spc105 and the dynein-targeting RZZ complex. hubs.la/Q02frJnM0 #Mitosis #CellDivision #Cytoskeleton
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Multimerization of a disordered #kinetochore protein promotes accurate chromosome segregation by localizing a core #dynein module, say Jessica McGory, Thomas Maresca @MarescaLab and colleagues @UMassAmherst: hubs.la/Q02frL-d0 #Mitosis #CellDivision #Cytoskeleton
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McGory et al @MarescaLab @UMassAmherst reveal that multimerization of the disordered #kinetochore protein Spc105 helps recruit a pool of the dynein-targeting RZZ complex to promote accurate chromosome segregation hubs.la/Q02frLw90 #CellDivision #Cytoskeleton #mitosis
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Check out the new @marescalab preprint (with @viktzv and Pat Wadsworth). Look at that dynein go! biorxiv.org/content/10.1101/…
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Very happy and proud to share the work PhD student Joana Lima @i3S_UPorto “A nuclear signal in prophase determines centrosome positioning and ensures efficient mitotic spindle assembly”, now online. biorxiv.org/content/10.1101/…

A nuclear signal in prophase determines centrosome positioning and ensures efficient mitotic...

Accurate centrosome separation and positioning during early mitosis relies on force-generating mechanisms regulated by a combination of extracellular, cytoplasmic, and nuclear cues. The identity of...

biorxiv.org
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Check out our new preprint: An intrinsically disordered kinetochore protein coordinates mechanical regulation of chromosome segregation by dynein biorxiv.org/content/10.1101/…

An intrinsically disordered kinetochore protein coordinates mechanical regulation of chromosome...

Kinetochores connect chromosomes and spindle microtubules to maintain genomic integrity through cell division. Crosstalk between the minus-end directed motor dynein and kinetochore-microtubule...

biorxiv.org
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Congrats to #UMass #Biology Assoc. Prof. & Dir. of the Molecular & Cellular Biology Program Tom Maresca @MarescaLab for being awarded a Fulbright Scholar Award! umass.science/3xZzSwx
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The Ndc80-Cdt1-Ska1 complex constitute a minimal processive kinetochore-microtubule coupling unit biorxiv.org/content/10.1101/…

The Ndc80-Cdt1-Ska1 complex constitute a minimal processive kinetochore-microtubule coupling unit

The Ndc80 kinetochore complex is essential for robust kinetochore-microtubule (k-MT) attachments during mitosis. Ndc80 has been shown to recruit the Ska1 complex to kinetochores, where Ska1 is...

biorxiv.org
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Spindle assembly in Xenopus egg extracts! Videos were taken while working late into the night at @MBLScience with Aaron Groen and @GatlinLab. The montage is from our (@viktzv) recent retrospective in @MBoCjournal on a seminal paper by @rebeccaheald. ow.ly/GTsW50HHlPY
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A celebration of the 25th anniversary of chromatin-mediated spindle assembly | Molecular Biology of the Cell molbiolcell.org/doi/full/10.…

A celebration of the 25th anniversary of chromatin-mediated spindle assembly | Molecular Biology of...

Formation of a bipolar spindle is required for the faithful segregation of chromosomes during cell division. Twenty-five years ago, a transformative insight into how bipolarity is achieved was...

molbiolcell.org
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If every school would do this, kids would learn so much more. slate.com/human-interest/202… via @slate

Grades Are the Worst Thing About College. Here’s My Genius Proposal to Fix That.

Call it pass-fail-plus.

slate.com
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Wish we could think seriously about the authors suggestion of an A/A-/Pass/Fail model, which is effectively the med school grading scheme.
Never knew Orville Wright had to fight his whole life (on behalf of he and his brother) for the Smithsonian to recognize they invented the airplane. washingtonpost.com/history/2…

Wright brothers vs. Smithsonian: The bitter feud over who invented the airplane

The Smithsonian gave credit to its director, Samuel Pierpont Langley, whose plane crashed into the Potomac River shortly after takeoff. The Wrights were not pleased.

washingtonpost.com
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Favorite line from the article: “Orville Wright died of a heart attack in January 1948. He had seen plane speeds go from 6.8 miles per hour on his first flight to 662 mph in 1947, when Air Force Capt. Chuck Yeager broke the sound barrier.”
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And here's another movie from our @MBoCjournal paper. This time the optogenetic oligomerization was triggered in interphase cells. molbiolcell.org/doi/10.1091/…
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A beautiful movie from our paper that just went live @MBoCjournal. molbiolcell.org/doi/10.1091/…
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Punchline: optogentically oligomerized KNL1 recruits PP1 to microtubules in mitosis. KNL1 oligomers can bind microtubules and PP1 simultaneously. The Cry2 oligomerization tag - developed in the Schaffer lab @UCBerkeley and used in @brangwynnelab OptoDroplet assay - is powerful!
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