Maier Lab @biozentrum @UniBasel -Structure and function of large complexes in metabolism - Twitter account managed by team members and Timm Maier.

Biozentrum, University of Basel, Switzer…
Joined June 2018
Congratulations to @Yves80289860 for completing his PhD in our lab @biozentrum 🥳🥳. Yves’ research provided a big leap forward in understanding the architecture of giant biosynthetic assembly lines known as modular polyketide synthases 👉bit.ly/3Lelpnp. 🎉
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Kind of agree, just updated the image for being happy with 20Å resolution.
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To keep all ghosts away from our Aektas and PCR machines, the Maier lab organised a pumpkin carving event yesterday night 👻🎃😱🐺 #Halloween #science @cryoLMC @hugomh87
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Next challenge is to understand how hybrid assembly lines formed by non-ribosomal peptide synthases and dimeric PKS are organized - in vitro and in cells #teamtomo
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Residual flexibility limits the resolution obtained for the overall assembly, but we reconstructed individual KS domains in the bimodule context at high resolution. This may eventually lead us to visualize chemistry and substrate handover as it happens inside a multimodular PKS.
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What is the organization of a #PolyketideSynthase assembly line ? #CryoEM studies of a filament of a trans-AT PKS bimodule core provide a first glimpse at multimodular PKS: science.org/doi/10.1126/scia…
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Congrats to @MatthiasZeug for receiving a Boehringer Ingelheim Fonds PhD fellowship 🎉. Matthias joined us for his PhD from @Grininger_Lab @goetheuni and is studying #mTOR signalling under stress. 🥳 #BIF #Biozentrum
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Congratulations to @FlorianXDelbart 💪💪, multienzyme hero for completing his joint PhD thesis in @MaierLab and @Basler_Lab🦠🧫 @biozentrum @UniBasel_en 👨‍🎓. All the best for your next challenge in @leadxpro @PARKinnovAARE 👨‍🔬
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Replying to @Challis_Group
@Challis_Group closing #DBVI   @RoySocChem. What a great meeting for the natural products community. So happy to have met great colleagues in person again @piel_lab, @SchmeingLab @Grininger_Lab @Hertweck_Lab @Masschelein_Lab  and many more...
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When the little ones are all grownup: Matthias (@mattwaelchli) is the latest PhD of the Maier lab! His work on DEPTOR has elucidated a new layer of #mTOR regulation (bit.ly/2Xf1ez9). Looking forward to further mTOR discoveries with you @biozentrum!
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