@MachidaLab

Molecular biology lab @NCIResearchCtr, @theNCI investigating DNA repair mechanisms. Views are my own.

 Bethesda, MD
Joined January 2020
  • Tweets136
  • Following146
  • Followers77
A new database developed by NCI scientists details how 2,675 different compounds affect the growth of #CancerCells. Learn more about this resource for researchers, called CellMinerCDB: NCATS. ccr.cancer.gov/news/article/…

With new database, NCATS data is poised to support development of precision cancer therapies

Data from thousands of compounds and nearly 200 cancer cell lines screened at the National Center for Advancing Translational Sciences are available through a new CellMiner database.

ccr.cancer.gov
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After 13 wonderful years at @MayoClinic, I am moving on to a new adventure. Starting January 2022, I’ll be joining @NCIResearchCtr, @theNCI as a Senior Investigator. – at Minnesota, USA
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Machida Lab retweeted
Shan Yan@ShanYanLab21 Aug 2020
Please RT (1/n): SI “Environmental Health and Genome Integrity” co-edited Cyrus Vaziri @UNC @ShanYanLab is published in @EMMjournal. Contributors include Nobel Laureate Aziz Sancar @UNC.. @EMGSUS @ChancellorGaber @UNCC_CLAS @UNCC_Academics @unccharlotte onlinelibrary.wiley.com/toc/…

Environmental and Molecular Mutagenesis | EMGS Journal | Wiley Online Library

Click on the title to browse this issue

onlinelibrary.wiley.com
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Online Now: Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging dlvr.it/RbHcq3

Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects...

Huang et al. discover the deubiquitinase VCPIP1 is required for SPRTN activation and further demonstrate that SPRTN activation is regulated by two-step post-translational modification, deubiquitina...

cell.com
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Machida Lab retweeted
Zha Lab@zha_lab12 Jun 2020
I am excited to launch the weekly Social DNAing webinar series on June 18,2020- a virtual meeting room for the genomic instability community. Check it out as cancer.columbia.edu/dna-webi…
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Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease cell.com/molecular-cell/full… – at Minnesota, USA
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Machida Lab retweeted
Cell@CellCellPress11 Jun 2020
In the latest issue! Rad54 promotes an #active mechanism for #homology searching during #homologous #recombination bit.ly/3hgfj4p @DNAcurtain @Columbia
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Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions by GLOE-Seq dlvr.it/RXzVmk

Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and...

We present a method for genome-wide, nucleotide-resolution mapping of DNA single-strand breaks in purified genomic DNA based on capture of 3′-OH ends followed by sequencing (GLOE-Seq). We validate...

cell.com
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BRCA1 Mutational Complementation Induces Synthetic Viability dlvr.it/RY2y3W
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Machida Lab retweeted
Cell@CellCellPress4 Jun 2020
New Article online now at Cell: Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination zpr.io/tWFwH
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via @NYTimes nytimes.com/article/how-to-r…

How You Should Read Coronavirus Studies, or Any Science Paper

Published scientific research, like any piece of writing, is a peculiar literary genre.

nytimes.com
Online Now: POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status dlvr.it/RXwcts

POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair...

Hodel et al. demonstrate that POLE cancer variants generate intense POLE hotspot error mutagenesis in human cells even in the face of functional post-replication MMR. The relative abundance of...

cell.com
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Synthetic lethality between DNA polymerase epsilon and RTEL1 bit.ly/2zPZ3Gx
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Online Now: Biomarker-Guided Development of DNA Repair Inhibitors dlvr.it/RXRdNS
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Online Now: Opposing Functions of BRD4 Isoforms in Breast Cancer dlvr.it/RXPMcF
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Online Now: Antibody RING-Mediated Destruction of Endogenous Proteins dlvr.it/RXPv4X
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Online Now: HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis dlvr.it/RXNWg8

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple...

Under replication stress, cells deficient in the fork remodeler HLTF fail to slow DNA replication. Here, Bai et al. report that, when HLTF is disrupted, replication is completed by alternative...

cell.com
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DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex dlvr.it/RX9RB3
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Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes dlvr.it/RXBJDX

Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes

Xing et al. show that nonrandom chromatid segregation, together with the asymmetric DNA damage response, is induced by replication stress, which ultimately leads to genomic instability and cell death...

cell.com
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TFIID Enables RNA Polymerase II Promoter-Proximal Pausing dlvr.it/RX5qYK
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