@SchertzerLab

Immunometabolism research: Diet, microbes, drugs and hormones

 McMaster University
Joined December 2012
  • Tweets2.2K
  • Following746
  • Followers1.5K
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GDF15 suppresses liver inflammation independently of weight loss through neuroendocrine glucocorticoid signaling cell.com/cell-metabolism/ful…

GDF15 suppresses liver inflammation independently of weight loss through neuroendocrine glucocort...

Growth differentiation factor 15 (GDF15) suppresses liver inflammation and fibrosis in metabolic dysfunction-associated steatohepatitis (MASH), which is independent of reduced food intake, body...

cell.com
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Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity. cell.com/cell-metabolism/ful…

Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity

The mechanisms coordinating the homeostasis of glucose, lactate, fatty acids, and ketones remain unknown. Through quantitative modeling and experiments, Weilandt et al. reveal that these nutrients...

cell.com
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Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP science.org/doi/10.1126/scia…

Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation...

Statins cause muscle side effects through an immunometabolism response that is separate from beneficial cholesterol lowering.

science.org
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Xenophagocytosis blockade enhances interspecies chimerism sciencedirect.com/science/ar…
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Advancing precision health discovery in a genetically diverse health system cell.com/cell/fulltext/S0092…

Advancing precision health discovery in a genetically diverse health system

The UCLA ATLAS biobank was utilized to integrate genetic data with electronic health records from individuals representing five continental and 36 fine-scale ancestries, identifying genotype-phenot...

cell.com
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Distinctive DNA sequence features define epigenetic longevity of inflammatory memory science.org/doi/10.1126/scie…

Distinctive DNA sequence features define epigenetic longevity of inflammatory memory

Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understo...

science.org
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Jonathan Schertzer (SchertzerLab) retweeted
AJP-Endocrinology and Metabolism@AJPEndoMetabMar 24
Take a short break to review today's Mini-Review #ArticleinPress, Immunometabolism of IRF4 in Adipose, #Muscle, and Immune Cells Influences #Obesity and MASLD (Daniel Marko and Jonathan Schertzer @McMasterU): ow.ly/BCin50Yyghs
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Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design cell.com/cell/fulltext/S0092…

Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design

A global genomic survey of infant gut bifidobacteria shows that B. infantis remains highly prevalent and diverse in infants from low- and middle-income countries but scarce in Western, industrialized...

cell.com
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Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis cell.com/cell/fulltext/S0092…
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Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma cell.com/cell-host-microbe/f…

Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung...

Yu et al. demonstrate that Staphylococcus is selectively enriched in metastatic lung tumor lesions. Staphylococcus nepalensis and S. capitis secrete lactate to promote the metastatic potential of...

cell.com
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Jonathan Schertzer (SchertzerLab) retweeted
Nature Metabolism
@NatMetabolismMar 4
TRIPping anti-tumour immunity through lactylation dlvr.it/TRHR2b

TRIPping anti-tumour immunity through lactylation

Nature Metabolism - KRAS mutations in colorectal cancers shape an immunosuppressive tumour microenvironment. In this issue of Nature Metabolism, Yang et al. report that TRIP6...

nature.com
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Preprint: CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation biorxiv.org/content/10.64898…
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Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease cell.com/cell-metabolism/ful…

Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-assoc...

Tang et al. reveal that high sugar intake promotes MASLD progression via microbiota-produced acetaldehyde, which drives fibrosis through MMP7 upregulation. An engineered probiotic, Ligilactobacillus...

cell.com
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Jonathan Schertzer (SchertzerLab) retweeted
Cell Reports@CellReportsFeb 24
Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity dlvr.it/TR7qyl

Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent...

Marko et al. show that elevated insulin in obese mice suppresses adipocyte IRF4, which governs fat versus muscle preservation during 5:2 intermittent fasting (IF) with or without caloric restriction....

cell.com
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Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity cell.com/cell-reports/fullte…

Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent...

Marko et al. show that elevated insulin in obese mice suppresses adipocyte IRF4, which governs fat versus muscle preservation during 5:2 intermittent fasting (IF) with or without caloric restriction....

cell.com
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Jonathan Schertzer (SchertzerLab) retweeted
Cell Metabolism@Cell_MetabolismFeb 23
New! Online now: Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis dlvr.it/TR6mSR
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Hepatic adaptation to chronic metabolic stress primes tumorigenesis: Cell cell.com/cell/fulltext/S0092…

Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Environmental stresses, such as a high-fat diet, disrupt liver cell balance by promoting pro-survival, developmental, and regenerative programs while impairing key tissue functions. These stress...

cell.com
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Jonathan Schertzer (SchertzerLab) retweeted
Daniel J Drucker@DanielJDruckerJan 14
In humans nighttime metabolic dysfunction is a hallmark of #MASLD with multiple pathogenic pathways upregulated at night, including hepatic and peripheral insulin resistance, DNL, and systemic NEFA exposure cell.com/cell-metabolism/ful… #circadian

Human MASLD is a diurnal disease driven by multisystem insulin resistance and reduced insulin...

By studying metabolism across day and night in human participants, Marjot et al. show that MASLD is a nighttime disease driven by poor insulin action and low insulin levels. These daily patterns...

cell.com
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Jonathan Schertzer (SchertzerLab) retweeted
Kevin Hall
@KevinH_PhD17 Dec 2025
It was a great pleasure to meet @richroll and discuss nutrition and metabolism science on the @RichRollPodcast!
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Jonathan Schertzer (SchertzerLab) retweeted
Mahla Poudineh@Mahla_Poudineh8 Dec 2025
Great time at the #NeurIPS2025, especially the chance to discuss our collaborative work with the @SchertzerLab and @Ali_Etemad1 and to connect with AI experts pushing time-series methods for health. I really enjoyed catching up with friends and colleagues: @Zjahed, @JWangnano
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