@M_MorganLab

Receptor Dynamics in Cancer Laboratory / Institute of Systems, Molecular & Systems Biology / University of Liverpool, UK

MorganLab.org
Joined September 2013
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Very excited to share our latest paper describing crosstalk between αvβ6 integrin & HER2 in breast cancer invasion & drug resistance. Great work by @HJMald & many others science.org/doi/10.1126/scia… @ScienceAdvances @LivUniISMIB @AdamHurlstone Many thanks to @BCCare @NorthWestCancer

A trafficking regulatory subnetwork governs αVβ6 integrin-HER2 cross-talk to control breast cancer...

Control of αVβ6 integrin and HER2 trafficking drives breast cancer invasion, drug resistance, and therapeutic response.

science.org
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NEWS | New insights in breast cancer progression and drug resistance ➡️ bit.ly/3OLKIhb #CancerResearch | #TeamLivUni
A news quote card with a navy blue background with a transparent image of someone in a lab coat looking at a scan. The quote is in white text and reads "This research could help us identify which patients are likely to be resistant as well as lead to new therapies for HER2-positive breast tumours, which are more targeted, and could ultimately stop people dying from this devastating disease.” Dr Simon Vincent, Director of Research, Support and Influencing at Breast Cancer Now.

ALT A news quote card with a navy blue background with a transparent image of someone in a lab coat looking at a scan. The quote is in white text and reads "This research could help us identify which patients are likely to be resistant as well as lead to new therapies for HER2-positive breast tumours, which are more targeted, and could ultimately stop people dying from this devastating disease.” Dr Simon Vincent, Director of Research, Support and Influencing at Breast Cancer Now.

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Mark Morgan's Lab retweeted
Ben Goult@bengoult10 Dec 2024
Look at the amazing speaker list for Adhere2 next September! This is going to be an excellent meeting, in beautiful Zadar, Croatia. event.fourwaves.com/adhere2/… – at Liverpool, England

2nd International Conference Focused on Cell Adhesion - ADHERE 2

Join 2nd International Conference Focused on Cell Adhesion - ADHERE 2, September 3-6, 2025. Learn more on Fourwaves.

event.fourwaves.com
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6) High levels of GDI2 expression correlate with better patient survival 7) Levels of αVβ6 expression at initial diagnosis predict disease relapse following trastuzumab treatment
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5) Components of the trafficking regulatory subnetwork are highly expressed in HER2+ breast cancers expressing high levels of αVβ6.
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6) High levels of GDI2 expression correlate with better patient survival 7) Levels of αVβ6 expression at initial diagnosis predict disease relapse following trastuzumab treatment
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A particularly intriguing observation: Invasion of trastuzumab resistant cells is αVβ6-independent. But resistant cells express very high levels αVβ6 on the cell surface. Opening up opportunities to potentially target them with an αVβ6-targeting warhead, or immuno-modulator
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5) Components of the trafficking regulatory subnetwork are highly expressed in HER2+ breast cancers expressing high levels of αVβ6.
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4) RAB5, RAB7A, and GDI2 differentially regulate invasion and αVβ6 integrin-mediated TGFβ activation, but this mechanism is uncoupled by trastuzumab resistance, rendering cells unresponsive to αVβ6, HER2 or TGFβ-Receptor inhibition.
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2) Components of the trafficking regulatory subnetwork mediate direct crosstalk between αVβ6 and HER2, affecting receptor trafficking and signalling. 3) Trastuzumab resistance disrupts αVβ6-mediated control of HER2 endocytosis and signalling.
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We show that: 1) Integrin αVβ6 recruits HER2 and a RAB5/RAB7A/GDI2 trafficking regulatory subnetwork. This recruitment is enhanced by exposure to the HER2-trageting drug trastuzumab, but dysregulated following acquired trastuzumab resistance.
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Mark Morgan's Lab retweeted
Ben Goult@bengoult27 Nov 2024
Very excited to share our new paper on Talin binding to Amyloid Precursor Protein indicating a new way to think about Alzheimer's Disease. It has the most provocative discussion section we have ever written :) royalsocietypublishing.org/d… – at Liverpool, England

The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of...

Abstract. Misprocessing of amyloid precursor protein (APP) is one of the major causes of Alzheimer’s disease. APP comprises a large extracellular region, a

royalsocietypublishing.org
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Mark Morgan's Lab retweeted
Horacio Maldonado@HJMald4 Dec 2024
Excited to share that our latest paper on the crosstalk between integrin αVβ6 and HER2 in HER2+ breast cancer is OUT! @M_MorganLab @LivUniCancer @ScienceAdvances @LivUniISMIB #BreastCancer #Trastuzumab science.org/doi/10.1126/scia…
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Mark Morgan's Lab retweeted
LCRI@LivCancerRes22 Nov 2021
Great to meet you face to face for the first time @M_MorganLab & thank you for a great talk @LivCancerRes #LCR121! So much opportunity for #collaboration in tumour micro-environment and #immuno-oncology studies across @LivUniISMIB @livuniHLS @livuninews @LivHPartners
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A PhD position with @PaulIAtherton is available in the department! "Mechanobiology of plasma membrane-associated signalling platforms" #PhD #CancerBiology findaphd.com/phds/project/me…
Paul Atherton@PaulIAtherton18 Mar 2024
Interested in how cells sense and respond to their environment? Want to do a PhD in Cell Biology? Come join me in @LivUniCancer @LivUni for a PhD! Fully-funded for UK-students. More information here: tinyurl.com/3ev8jd6v
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