Talin as a memory molecule #MeshCODE. Talin shock absorbing materials #TSAM. Prof at @LivUniISMIB Hobbies: Mechanobiology, talin, looking at the sky
University of Liverpool
Joined October 2010
- Tweets3.6K
- Following617
- Followers1.6K
- Likes11.7K
Pinned Tweet
Excited to share our new study @biorxivpreprint
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵the paper is summarised in this video.
youtube.com/watch?v=WC6t-A5G…
Ben Goult retweeted
Excited to share our new study @biorxivpreprint
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵the paper is summarised in this video.
youtube.com/watch?v=WC6t-A5G…
biorxiv.org/content/10.1101/… CDKL5 is an essential kinase in the brain, and mutations in the CDKL5 gene cause a devastating childhood epilepsy condition, called CDKL5 Deficiency Disorder (CDD).
Brilliant work led by Yasumi Otani in the lab, Neil Ball, and great collaborations with Emily Goodall and @zech_lab Tobi Zech, and Vignesh Srinivasan and @SaarikangasLab
Ben Goult retweeted
At the end of a challenging year, in collaboration with Tamar Harel, Naama Elephant, @bengoult, we found a #Talin 1 mutation that is genetically associated with #SCLS and affects#endothelial #permeability linking #cell- #ECM adhesion to #adherens Junction insight.jci.org/articles/vie…
Our new paper on pathogenic Talin1 mutants that cause Systemic Capillary Leak Syndrome :)
This quoted post is unavailable.
Ben Goult retweeted
Excited to share our latest paper, now published! Huge congratulations to @kolasangiani , PhD student in @UtahBME and @uusci, for his outstanding work. Check it out here: cell.com/structure/fulltext/…
#Research #BME #PhD #NewPublication
*Fully funded PhD position available in the lab*
We will use structural proteomics to map the mechanosensitive interactions of talin in dendritic spines and how they change during long term potentiation.
Please RT, and email/message for details
findaphd.com/phds/project/bb…
Exciting project with co-PIs, @xlinkx_pd and @PaulIAtherton at @LivUniISMIB and @MJ_Humphries
at @wtccmr – at Liverpool, England
Look at the amazing speaker list for Adhere2 next September!
This is going to be an excellent meeting, in beautiful Zadar, Croatia.
event.fourwaves.com/adhere2/… – at Liverpool, England
"Mechanical switches and protein meshes – this is a new way of looking at one of our most feared diseases."
A Shapeshifting Protein Is Leading Alzheimer’s Disease Researchers Down A New Path
iflscience.com/a-shapeshifti…
Ben Goult retweeted
NEWS | A new study represents a significant step forward in understanding #Alzheimer’s.
Investigators examined two proteins found in the brain and suggest the stability of their relationship is crucial for memory formation⬇️
news.liverpool.ac.uk/2024/11…
ALT An illustration of the brain synapses with text overlaid that reads, 'News: Possible answers on Alzheimer's disease'
Very excited to share our new paper on Talin binding to Amyloid Precursor Protein indicating a new way to think about Alzheimer's Disease.
It has the most provocative discussion section we have ever written :)
royalsocietypublishing.org/d… – at Liverpool, England
Great work by Charles Ellis, Natasha Ward, Matthew Rice and Neil Ball, with excellent collaboration for the cellular neuroscience work by Pauline Walle, Chloe Najdek, Deverim Kilinc, Jean-Charles Lambert and Julien Chapuis at Institut Pasteur de Lille.
the story is summarised in this 20 second animation.
youtube.com/watch?v=csMs8-ZU…
Press release on our new paper linking talin to amyloid precursor protein (mis)processing indicating that there is a mechanical basis of Alzheimer's disease. news.liverpool.ac.uk/2024/11… @LivUniResearch @UniKent @PasteurLille – at Liverpool, England
Ben Goult retweeted
Our Special Issue on Imaging Cell Architecture and Dynamics is now complete.
You can explore our ToC here: journals.biologists.com/jcs/…
‘Breaking symmetry’ from @AntaraC9 was the winning image from our cover competition with @focalplane_jcs. The image is a MEF labelled with phalloidin (green), acetylated tubulin antibody (magenta) & DAPI (blue).
ALT Journal of Cell Science cover showing a MEF labelled with phalloidin (actin – green), acetylated tubulin antibody (magenta) and DAPI (DNA – blue). Special Issue on Imaging Cell Architecture and Dynamics Guest Editors: Lucy Collinson and Guillaume Jacquemet The Company of Biologists logo
Ben Goult retweeted
Want to develop your career in cancer metabolomics in a leading lab? 5 year @CRUKresearch post-doc position available in @rickdunnblade group. Come work in Liverpool. Info available at tinyurl.com/sj7kpxwz. Please repost.
Good day to reshare this @BBCWorld article on AlphaFold, David Baker's protein design work and our Talin Shock absorbing materials @NatureNano paper. Good company to be in! #NobelPrizeinChemistry bbc.co.uk/news/business-6546… #shamelessselfpromotion @JenniferHiscoc2 – at Liverpool, England
nature.com/articles/s41565-0… – at Liverpool, England
