Neuropsychologist turned Medical Science Liaison. Passionate about patient care & improving the dx and tx of neurodegenerative diseases. Views are my own.
San Francisco, CA
Joined January 2020
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Marianne Chapleau retweeted
🚨NEW PREPRINT: An atypical phenotype is a risk factor for higher mortality in Alzheimer’s disease
@ilse_bader shows that an atypical (non-amnestic-predominant) clinical presentation is an important risk factor for mortality beyond age, sex, education, APOEε4-carriership and disease severity.
Link @medrxivpreprint: medrxiv.org/content/10.1101/…
@Colin__Groot @AlzheimerAms
Marianne Chapleau retweeted
📣 Postdoc Hiring📣
Join our project on how social health impacts cognition & resilience with a focus on women’s health
✅ Longitudinal data expertise
✅ Passion for aging research
✅ Team-oriented mindset
📍Karolinska Institutet 🇸🇪
💼 Apply now:
ki.varbi.com/en/what:job/job…
Marianne Chapleau retweeted
Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP doi.org/10.1007/s00401-024-0…
Marianne Chapleau retweeted
ARIA-E in Alzheimer disease is more likely in those with APOE ε4, microhemorrhages, low CSF Aβ42, and high Fazekas scores, but it does not generally worsen long-term cognition or function. ja.ma/4fOVui3
Marianne Chapleau retweeted
#CurePSP is now accepting applications for the Student Fellowship Program. This program supports students engaged in research on PSP and CBD, providing resources to drive meaningful advances in the field.
Deadline: January 31, 2025, by 5pm ET
psp.org/iwanttolearn/student…
#Research
Marianne Chapleau retweeted
Study found frailty accelerates up to 9 years before dementia onset and is a key early marker. Frailty was linked to higher dementia risk even when measured years before dementia onset and may represent a target for prevention efforts.
ja.ma/4hLFake
Marianne Chapleau retweeted
📢 Looking for a postdoc opportunity in neuroimaging research! 🎓 My focus: Alzheimer’s disease, cognitive aging, & functional networks. Skilled in multiple MRI modalities and neuropsych. Excited to connect with labs! #Postdoc #AlzheimersResearch #Neuroimaging
Marianne Chapleau retweeted
Join us at #AAICAdvancements Exploring Equity in Diagnosis, Nov. 18-19 in Chicago and online! Be a part of the conversation around addressing disparities in an era of modernizing diagnosis for Alzheimer’s and other dementias. #ExploringEquity24 alz.org/exploringequity
Marianne Chapleau retweeted
Whelp. Maybe a good time to mention that I am about to open a new PhD position in Sweden that just happens to be exactly four years in length. Any aspiring PhD candidates in neurodegenerative imaging or multiomics who want to "take a break" from the US, please get in touch!
Marianne Chapleau retweeted
Lewy body pathology exacerbates brain hypo-metabolism and cognitive decline in Alzheimer’s disease
Great work led by @LECollij. Using ADNI data, she showed that the presence of LB pathology (CSF SAA) exacerbates global cognitive decline in symptomatic AD and is associated with more pronounced hypo-metabolism (FDG PET), particularly in posterior cortical regions.
Link @NatureComms (open access): nature.com/articles/s41467-0…
@biofinder_study @SEMastenbroek @NiklasMattsson4 @SebastianPalmqv @OskarHansson9
Marianne Chapleau retweeted
Very happy to share our new work out in @alzdemjournals, showing that combining PI-2620 tau-PET and fluid p-tau markers can help discriminate 4R tauopathies vs. AD. Huge thanks to first author @dilcher_r and co-senior @matbrendel
doi.org/10.1002/alz.14185
Marianne Chapleau retweeted
Current projections estimate 153 million people will be living with dementia by 2050.
Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors starting in childhood, suggests new report from a standing Lancet Commission: buff.ly/46nvoPR
ALT Lancet infographic conceptualising risk factors for dementia.
Marianne Chapleau retweeted
BREAKING: Exposure to wildfire smoke increases the risk of being diagnosed with dementia more than other types of air pollution, according to new research presented at #AAIC24. aaic.alz.org/releases-2024/e…
Marianne Chapleau retweeted
🚨Preprint alert!
We are pleased to present our latest work: “Prediction of future cognitive decline among cognitively unimpaired individuals using measures of soluble phosphorylated tau or tau tangle pathology” led by @RikOssenkoppele and @gesalbla.
medrxiv.org/content/10.1101/…
Marianne Chapleau retweeted
Please RT!📢 The CHEN Lab is hiring a lab manager at SUNY - Stony Brook University. The lab manager will support various research projects in the lab. It is ideal for someone considering graduate school in psychology, neuroscience, etc. Apply before 6/21! stonybrooku.taleo.net/career…
Marianne Chapleau retweeted
Super happy to share our new work in @Brain1878 by @RoemerSeb and @matbrendel:
in 4R tauopathy patients, we show that subcortical tau deposition is linked to hypoperfusion in connected cortical regions, suggesting a diaschisis-like disconnection mechanism.
doi.org/10.1093/brain/awae17…
Marianne Chapleau retweeted
First autopsy validation of PET tracer PI-2620 in #progressivesupranuclearpalsy confirms it binds 4R tau deposits. @LMU_Muenchen ow.ly/FJkn50RTzmP
Marianne Chapleau retweeted
Earlier this month in Sacramento, we held our California Advocacy Day with more than 175 volunteers from across the Golden State. Thank you to our advocates for speaking up on behalf of their local #EndALZ communities.
Marianne Chapleau retweeted
St-Onge et al. report that, despite following the classical Braak stages, patterns of #tau pathology differ between individuals on the spectrum of typical #Alzheimersdisease, and accounting for that variability improves associations with cognitive domains. shorturl.at/lAE17
Marianne Chapleau retweeted
Hopeful to join the neuroimaging PIA executive committee @NeuroimagingPIA as I run for the trainee representative position 💜!
@ISTAART members make sure to cast your votes by April 8th!
📢 Calling all ISTAART members! Shape the future of your Professional Interest Areas (PIAs) by participating in the 2024 PIA Elections.
Cast your vote today and have your say in the leadership of your PIA! 🗳️🌟
Vote now at alz.surveymonkey.com/r/2024P…
