@MUN_science

PhD student @ KAIST Tumor Microenvironment | Disease modeling | Organoid

 Republic of Korea
Joined June 2025
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  • Following85
  • Followers7
In vitro and in vivo derived macrophages occupy distinct phenotypic states biorxiv.org/content/10.1101/… #biorxiv_immuno

In vitro and in vivo derived macrophages occupy distinct phenotypic states

Monocyte-derived macrophages (MDMs) are widely used to model human macrophage biology in vitro and standardized polarization conditions were proposed to recapitulate the different macrophage activa...

biorxiv.org
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RESEARCH | AD Rao, L Cai, RJ DeBerardinis, @JenniferGillMD et al (@UTSWMedCenter) A detailed metabolic comparison between primary #tumours from #patients and their matching #xenografts, which identifies conserved as well as divergent #MetabolicPatterns nature.com/articles/s42255-0…
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An age-related decrease in leptin contributes to CD8+ T cell aging in the tumor microenvironment @CellRepMed cell.com/cell-reports-medici… 🇨🇳
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My lab @MBIsg and @NUSMedicine is recruiting a fully-funded postdoc to start in Jan 2026! Interested in cell and tissue mechanics, transcriptional regulation of tissue health, or AI/ML for disease mechanobiology? Come join us in Singapore! mechano-medicine-lab.com/pos…
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🚨 REVIEW 🚨 #Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups. bit.ly/41R6Qxt
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The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard
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NEW content online! Ageing, immune fitness and cancer bit.ly/3JdVu0c
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NEW content online! Stromal senescence contributes to age-related increases in cancer bit.ly/40NxWFw
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Part Three of a series of investigations from my lab (ttelab.com) looking at how we can recapitulate cancer-associated fibroblast (CAF) heterogeneity in vitro, is now out in Advanced Healthcare Materials! 👉 lnkd.in/g2nKGvWH

Translational Tumor Engineering Laboratory

Led by Dr. Eliza Fong, the Translational Tumor Engineering Laboratory aims to develop translational tumor models for cancer research using bioengineering tools.

ttelab.com
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Temporal dynamics of CLDN18.2 expression following zolbetuximab treatment in advanced gastric cancer - ESMO Gastrointestinal Oncology esmogastro.org/article/S2949…

Temporal dynamics of CLDN18.2 expression following zolbetuximab treatment in advanced gastric cancer

Zolbetuximab plus chemotherapy is the standard of care for unresectable advanced gastric cancer that is human epidermal growth factor receptor 2-negative and claudin-18 isoform 2 (CLDN18.2)-positive...

esmogastro.org
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Online Now: Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer dlvr.it/TM5hVJ
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💡 Scientists at @unil found that glutamine synthesis by CAFs promotes the polarization of pro-tumorigenic TAMs and supports tumor growth by altering TAM composition, highlighting the pivotal role of CAFs in shaping the immunosuppressive TME. @JExpMed | bit.ly/4lFVTXt
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Everyone working in a STEM field should read this - ‘writing is thinking’ nature.com/articles/s44222-0…
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Foam cells are dysfunctional, lipid-laden macrophages. Data indicate that the events underlying foam cell formation are disease- and microenvironment-specific, opening new avenues for disease-specific biomedical research. Learn more: ow.ly/Ah0k50WlLiQ.
Spatial distribution of foam cells and storage lipids in C. neoformans-infected murine lungs. (A, B). H&E staining of formalin-fixed, paraffin-embedded lung sections from C. neoformans H99-infected mice. Images were photographed at (A) 100× magnification; scale bar is 100 μm; and (B) 400x magnification; scale bar is 10 μm. Black arrows indicate foam cells.

ALT Spatial distribution of foam cells and storage lipids in C. neoformans-infected murine lungs. (A, B). H&E staining of formalin-fixed, paraffin-embedded lung sections from C. neoformans H99-infected mice. Images were photographed at (A) 100× magnification; scale bar is 100 μm; and (B) 400x magnification; scale bar is 10 μm. Black arrows indicate foam cells.

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Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models dlvr.it/TM0Npb
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I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) nature.com/articles/s41586-0…

Neutrophils drive vascular occlusion, tumour necrosis and metastasis

Nature - Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

nature.com
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Enjoy! 🧩 openbookpublishers.com/books…
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Lars Kemp (@kemp_lars) and a team in the @GloerichLab analyzed gastric tumors to identify the molecular changes that contribute to the progression of indolent to aggressive diffuse-type #GastricCancer legions. 🔖 @Gut_BMJ: bit.ly/44SiD0r
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"No one’s Ph.D. journey is the same, and no one deserves to be shamed for how long it takes." #ScienceMagArchives scim.ag/3PjwJzf
An illustration of a woman riding a large turtle with a stack of papers behind her. Text reads: My Ph.D. took a long time—and there's no shame in that

ALT An illustration of a woman riding a large turtle with a stack of papers behind her. Text reads: My Ph.D. took a long time—and there's no shame in that

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