Cellular immunity in psychiatry | co-chair, PGC Functional Genomics workgroup | Clinical Lecturer, University of Cambridge
Cambridge, UK
Joined December 2009
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🧠📘 **New Book**The Cambridge Textbook of Neuroscience for Psychiatrists is out! Coedited by yours truly, Peter Jones, and @DrSteveStahl @CambridgeUP 👉amzn.to/46kZfGP 1/n
Fancy a 4-year post-doc in Cambridge, working in both the biggest biomedical centre in Europe @psychiatry_ucam @CambridgeBRC and the genetic powerhouse of the @sangerinstitute?
You would be part of the dynamic UKRI ImmunoMind Hub @MHPlatform and analyse an extraordinary new immunogenetic dataset from patients recruited as part of the UK Mental Health Mission.
If you have experience in statistical genetics or single cell analysis and this sounds interesting, get in touch for a chat about the post. Here's the job advert, applications due 16th March. jobs.cam.ac.uk/job/50251/
Mary-Ellen Lynall retweeted
Yesterday, we gave you an intro to the🧬RNA and protein isoforms🧬group, lead by the awesome @psyEpigenetics
Now, let’s take a sneak peek🫣at the✨main outcomes✨of the group this year, ft. @rbamford5!
Check out their responses👉🏽
Mary-Ellen Lynall retweeted
✨Get EXCITED!✨
It's time for the @pgc_fg main account takeover!
For the next 2 weeks @BertholdNatasha and @Eva_C_Schulte will be taking you through year 1 of PGC's Functional Genomics Working Group.
So join us, as we get to know PGC FG and celebrate 1 year up and running🥳!
Mary-Ellen Lynall retweeted
Here’s to the end of our first in-person meeting of the @pgc_fg working group at #WCPG2024. Thanks to all participants and my co-chair @MLynall! Very exciting updates and new plans made for leveraging @PGCgenetics data to increase our understanding of psych disorders.
Check out our intro video for the new @PGCgenetics functional genomics group courtesy of @BertholdNatasha - and sign up to get involved!
To find out more about who we are and how YOU can be involved, check out our intro video below!⬇️⬇️ #science #Genetics #PsychiatricGenetics
Mary-Ellen Lynall retweeted
We're so excited to post our first article promotion 📰🥳
@LTrastulla et al colab'd with the Ziller Lab and @PGCgenetics SCZ working group to show the high level of clinical heterogeneity characteristic to #geneticallycomplex diseases, in particular #psychiatricdisorders
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Mary-Ellen Lynall retweeted
Massive thank you to more than 5 million participants & 300 investigators worldwide who made this study possible
New pre-print from the @PGCgenetics #Depression Group: Multi-ancestry GWAS of depression with 685,000 cases identifies 697 independent associations, implicating known & novel drug targets.
🔗 medrxiv.org/content/10.1101/…
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ALT Diagram of analysis design for PGC MDD GWAS. Diverse ancestries discovery GWAS analyses starts with European ancestry meta-analysis, which is used for bioinformatic and mechanistic analysis; fine-mapping and expression-based gene mapping; tissue, cell, and pathway enrichment analyses; and drug target enrichment analyses. All ancestries meta-analysis is used for predictive testing within and across ancestries.
Mary-Ellen Lynall retweeted
One more week to apply! Come join us in @humantechnopole if you are interested in B cell biology, CRISPR screens and immunogenomics.
Two Postdoc positions in my lab @humantechnopole! Please RT!
We have an @OpenTargets project in collaboration with @GosiaTrynka lab. An ambitious project, with industry partnership to comprehensively understand regulators of B cell activation using CRISPR screens.
Mary-Ellen Lynall retweeted
Postdoc position to join my new group @OxPsychiatry and @bdi_oxford. UKRI funded "CHECKPOINT: Finding immune & metabolic pathways to SMI" led by @edbullmore, direct supervision from @MLynall collaborating with @mcintosh2001 . my.corehr.com/pls/uoxrecruit…
Mary-Ellen Lynall retweeted
Our next @PGCgenetics WorldWide Lab meeting is an introduction to the new Functional Genomics working group, April, 22, 9:00 am EST
Talks on Cross-tissue meta-EWAS; data-driven prioritization of cells and circuits in schizophrenia
@MLynall @HjerlingLeffler @JanitzaMontalvo
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Perfectly summarised. Devastating for the next generation of potential clinical academics, and for the UK biomedical research landscape.
So, @bykatewomersley @marinadpol and I wrote something.... please take a look!
Changes to the UK foundation programme add further challenges for doctors pursuing clinical academic careers bmj.com/content/384/bmj.q485
Mary-Ellen Lynall retweeted
So honoured to have contributed as an Associate Editor in this new #StahlPsychopharmacology Prescriber's Guidelines
Thank you @CambridgeUP and to our amazing group of editors 🤓 – at Cambridge, England
This has been a 4 year labour of love and it's been an honour to work with such a cracking team of editors and contributors 👉amzn.to/46kZfGP
