Milano, Lombardia
Joined October 2017
- Tweets30
- Following161
- Followers106
- Likes56
🎉 Super thrilled to announce my PhD work is finally out.🥳 This work moved a step forward towards personalised medicine paradigms. Huge shout out to all the amazing co-authors, ZillerLab and @IorioLab for making this possible 🙌 nature.com/articles/s41467-0…
Keep an eye on the project GitHub github.com/zillerlab/CASTom-… for future developments! 🚀
Huge congrats to Dr. @Ale_Vinceti for the amazing defence. And thanks so much to @IorioLab and @Francesco_i0ri0 for this beautiful years and for the opportunity to be part of such an amazing team ❤️
This Post is from an account that no longer exists. Learn more
Lucia Trastulla retweeted
Delighted to share that my first author paper is online. We used massively parallel reporter assay, single cell CRISPRi, iPSC derived neurons, and OMICs to functionally annotate schizophrenia GWAS variants. Check this out: authors.elsevier.com/c/1hxN2…
@ImprsTp @mpi_psychiatry #mpra
Now online! Massively parallel functional dissection of schizophrenia-associated noncoding genetic variants dlvr.it/SxZd0y
Lucky to be in such a great lab and to work with amazing people❤️
This Post is from an account that no longer exists. Learn more
The preprint from my PhD work in the lab of Prof. Ziller at the @mpi_psychiatry is finally out!
medrxiv.org/content/10.1101/…
To achieve this, we developed a new pipeline called CASTom-iGEx that operationalizes individual-level genotype data to interpret personal polygenic risk and identify the genetic basis of clinical heterogeneity.
Huge thanks to all the collaborators (Prof. Müller-Myhsok, Prof. Schunkert, @Prof_TGSchulze, @AlexanderTeumer) and all the individuals taking part in the so precious genetic studies (@uk_biobank, @PGCgenetics, #CARDIoGRAM, #PsyCourse, #SHIPTREND)
Lucia Trastulla retweeted
Very excited to share my first-author publication on the role of extracellular vesicles in interneuron specification! @silvianeurompi
@NataliaBaumann7
@denisjabaudon
@AndreaForeroE
@rossdigiaimo
@RebeccaB0n
@ScienceAdvances
science.org/doi/full/10.1126…
Exciting poster session at the @NIH during the SSACB. It was very insightful to discuss our method for correcting gene independent effects of combinatorial CRISPR-Cas9 screenings. Picture courtesy of @Ra_LeNoir, random clothes due to delayed luggage courtesy of @Target
Lucia Trastulla retweeted
📢 Calling all scientists!
Join us for the 1st European Cancer Dependency Map Symposium #EUDepMap with top researchers from @Humantechnopole @emblebi @sangerinstitute @ETH_en on cutting-edge research on cancer vulnerabilities and therapeutic targets.
bit.ly/3TdGLU3
Lucia Trastulla retweeted
Our @Ale_Vinceti from @IorioLab of @Francesco_i0ri0 presents new tools to identify reference gene sets of minimal size allowing supervised analyses of scale-limited #CRISPRCas9 knock-out screens, while having a reduced impact on the screen size.
humantechnopole.it/en/news/n…
Our review from @IorioLab in collaboration with colleagues at @broadinstitute @CancerDepMap is finally out doi.org/10.15252/msb.2022110…! Can computational methods aid at estimating the quality of cancer cell lines as in vitro models for tumours?
Highlights in this 🧵
to conclude, large characterisations of CCLs as well as the development of computational methods to align and compare cancer models and tumour patients will be essential in the near future to the realisation of the personalised medicine paradigm 11/11
Thanks to coauthors @DrFranVazquez @CancerDataSci @Francesco_i0ri0,
the @MolSystBiol journal, and to @OpenTargets @CancerDepMap and @humantechnopole for supporting this work