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Gastric adenocarcinoma in the peritoneum! So many signet cells
#cytopathology #pathology
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Basal cell adenoma is a benign salivary gland tumor, mainly of the parotid gland, with biphasic basaloid and ductal cells. It shows varied growth patterns, peripheral palisading, and nuclear β-catenin positivity at the periphery (CTNNB1 mutations). #pathology #pathtweet
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Europe where a white Woman is harassed by Islam for nor covering her self up.
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Recent data on ER low positive
Up to 7000 patients with ER-low early stage breast cancer who received chemotherapy
42% omited endocrine therapy
Those who omited had a 23% high risk of death, especially if they did not achived pCR or ER was 6-10%
How to comment on ER-low positive resuts (pathology reports), pic 2
Dr. Allison. 2026 Diagnostic Pathology Update #USCAP #pathology #PathX
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El TDAH no es solo un problema de la infancia. Es un trastorno del neurodesarrollo que causa dificultades para prestar atención o para controlar el impulso y la hiperactividad, y aunque antes se pensaba que se superaba al crecer, los estudios de seguimiento demuestran que en muchos casos los síntomas continúan en la vida adulta y afectan el trabajo, las relaciones y la salud. Por eso es importante reconocerlo y tratarlo también en adultos.
ADHD is a neurodevelopmental disorder characterized by symptoms of inattention or hyperactivity–impulsivity. Although it has long been considered to be a childhood-limited condition, follow-up studies have shown a persistent course into adulthood. Learn more: nej.md/4s25aNL
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Oncogenic mutations in non-small cell lung cancer: from molecular mechanisms to clinical practice
A very comprehensive review👇
nature.com/articles/s41392-0…
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When can HER2 IHC help in DCIS?
In an intraductal proliferation with apocrine features and intermediate- to high-grade atypia
Diffuse strong score 3+ HER2 staining supports DCIS and is not expected in hyperplasia
HER2 does not help with low-grade DCIS, or with ADH vs borderline DCIS
Dr. Allison. 2026 Diagnostic Pathology Update #USCAP #pathology #pathX
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Chemoprevention: Risk-reducing endocrine therapy is strongly recommended (NCCN)
ADH/ALH = 86% reduction in breast cancer risk
LCIS>50% reduction
Dr. Allison. 2026 Diagnostic Pathology Update #USCAP #pathX #pathology
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Recently shared this interesting case at our interesting case conference and now want to share it with you all :) Core needle biopsy of a well circumscribed lesion in a pre-menopausal female #breastpath #pathx #pathtwitter #pathresidents
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Extra-nodal Rosai Dorfman disease shows overlapping features with IgG4-related fibrosclerosing disease - storiform fibrosis and inflammation. The S100 stain highlights emperipolesis with nuclear (short arrows) and cytoplasmic staining; engulfed cells are negative (long arrows).
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As we bring our “best options” upfront… what do you do if we do not see anticipated response to these neo-adjuvant Rx?
Breast Cancer: After TDXd in NeoAdj… if there is gross residual disease… switch to TDM1? Continue w/ TDXd in Adj? @PTarantinoMD @hoperugo @drsarahsam
@JavierCortesMD
Bladder Cancer: After EV-Pembro… if there is minimal response… in Adj settings… continue with EV-Pembro? Consider Chemo? @PGrivasMDPhD @shilpaonc @tompowles1 @drenriquegrande
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Update of Surgical Management Recommendations for High-Risk Lesions of the Breast, part 2
Pure flat epithelial atypia (FEA):
- No excision
- Consider confirmatory 2nd review to exclude ADH
- Consider excision if extensive calcifications or not adequatly sampled
Dr. Allison. 2026 Diagnostic Pathology Update #USCAP #pathology #PathX
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October is Breast Cancer Awareness Month, inspiring our case of the month:
A 70yoW presents with a single, lobulated, retroareolar breast mass. A-B H&Es, C P63, D SMM-HC
See the poll below - what's your diagnosis? Answer and discussion out in a couple of days!
#BreastPath
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One image is all you need to tell me the origin of this brain tumor. (Dive deep into the BOWELS of your #pathology knowledge base for this one.) #neuropath #pathtwitter
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Update on Surgical Management Recommendations for High-Risk Lesions of the Breast (American Society of Breast Surgeons)
ADH: Surgical excision.
Recommendation to do a confirmatory 2nd review (pathology)
Exceptions: Patients who meet low-risk criteria may be considered for observation (see pic)
Pathology low-risk criterion:
- Focal ADH on pathology (what is considered focal? see pic below)
Dr. Allison, 2026 Diagnostic Pathology Update #USCAP #pathology #PathX
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The FDA approved 22 new drugs in Q3 2026.
Key oncology approvals:
- Daraxonrasib
- Gedatolisib
- Camizestrant
- Zidesamtinib
- Lirafugratinib
Daraxonrasib leads commercial forecasts, with projected annual sales of $6.6 billion by 2032.
nature.com/articles/d41573-0…
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Breast Risk lesions
Radiology standard (US): Referral to surgery if upgrade risk >3%.
Dr. Allison. 2026 Diagnostic Pathology Update #USCAP #pathology #PathX
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Answer reveal: DCIS involving lobules! 🔬
DCIS creeping into lobules can mimic ALH, particularly when seen in isolation! The strong membranous E-cadherin staining confirms ductal differentiation.
Thank you to all who joined our session at #IAP2026!
#breastpath #PathTwitter
🤖 Made with AI
What’s the diagnosis of this breast lesion? 🤔🔬
Poll in comments 👇
Answer reveal on Monday 🔮
📅 Specialty Conference 25 | Oct 11 | 6–8 PM
📍#IAP2026 | Fukuoka 🇯🇵
👨🏫 “Problems in Breast Pathology” Revisited
#PathX #PathTwitter #breastpath #PathQuiz























































