Lymphocyte Development and Epigenetic Memory Research Groups @MRC_LMS Tweets by lab members
Joined July 2020
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We are on Twitter! Our @MRC_LMS research group, run by Professors Amanda Fisher and Matthias Merkenschlager, is based at @ImperialMed Hammersmith Campus. We study how #GeneExpression patterns are established, transmitted through #CellDivision and changed during #Development.
Our latest study “Competition shapes the landscape of X-chromosome-linked genetic diversity” is now out in @NatureGenet
🧬DNA inherited from one parent is expressed more in some parts of the body, and the reverse in others. New study in @NatureGenet shows how competition between X chromosomes in females shapes who we are News here ➡ lms.mrc.ac.uk/just-like-your… Paper here ➡nature.com/articles/s41588-0…
Lymphocyte Development & Epigenetic Memory Groups retweeted
💡A living sensor to evaluate the impact of environment on gene expression & health. A new LMS @LymphDev study in @CommsBio uses the light of a firefly to illuminate cells, revealing how vulnerable our lungs are to external factors.
Read more: lms.mrc.ac.uk/news/
Lymphocyte Development & Epigenetic Memory Groups retweeted
.@ediem_aljibury @LymphDev @DanielRueckert adapt neural networks to the replicate-based analysis of Hi-C data and find that it successfully discriminates technical noise from biological variation. @MRC_LMS @imperialcollege
#BiotechNatureComms
nature.com/articles/s41467-0…
Happy to share our study in which we used Siamese neural networks to develop a #DeepLearning method for replicate-based analysis of chromosome conformation contacts, in collaboration with @DanielRueckert, spearheaded by @ediem_aljibury nature.com/articles/s41467-0…
Lymphocyte Development & Epigenetic Memory Groups retweeted
#New publication by Epigenetic Memory makes exciting advances in using new #Bioluminescent tools in #epigenetic silencing research. These tools could aid the development of #epidrug therapies for diseases such as #cancer.
👉ow.ly/t7Uh50NMKzM
@LymphDev @A_M_Dimond @Nature
Lymphocyte Development & Epigenetic Memory Groups retweeted
Gene Team – Mouse model for specialised molecular screening therapeutic strategies for #Duchennemusculardystrophy. Video & research by Hannah Gleneadie & Beatriz Fernandez-Ruiz et al @LymphDev @MRC_LMS in @CommsBio. More on bpod.mrc.ac.uk/archive/2023/… with @MRC_LMS & @DrJohnAnkers
Lymphocyte Development & Epigenetic Memory Groups retweeted
The #EpigeneticMemory group published in @CommsBio on a potential new therapeutic strategy for #DMD 🎉.
Bioluminescent gene reporters were used to model #GeneExpression, and researchers found compounds that increase utrophin in developing muscle cells.
👉ow.ly/Xg8Z50NwWUK
Lymphocyte Development & Epigenetic Memory Groups retweeted
Very excited to finally see our study out! We developed new models to study utrophin and dystrophin's gene expression patterns in vivo by bioluminescence and explored possible therapeutic options for Duchenne Muscular Dystrophy.
The #EpigeneticMemory group published in @CommsBio on a potential new therapeutic strategy for #DMD 🎉.
Bioluminescent gene reporters were used to model #GeneExpression, and researchers found compounds that increase utrophin in developing muscle cells.
👉ow.ly/Xg8Z50NwWUK
A wonderful weekend read from us!
Our study "Endogenous #bioluminescent reporters reveal a sustained increase in #utrophin gene expression upon EZH2 and ERK1/2 inhibition" is now out in @CommsBio
Paper: nature.com/articles/s42003-0…
@MRC_LMS @ImperialMed
Story👇
lms.mrc.ac.uk/new-breakthrou…
Lymphocyte Development & Epigenetic Memory Groups retweeted
H3K9me3 is important for chromosome architecture and epigenetic memory during cell division.
Drs. Amanda Fisher and Dounia Djeghloul's team showed that enzymes that catalyze H3K9 #methylation are retained on mitotic #chromosomes 🧬. @LymphDev @MRC_LMS
go.nature.com/3TzUB38
We are happy to share that our study "Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis" is now out in @NatureSMB
lms.mrc.ac.uk/unlocking-the-…
nature.com/articles/s41594-0…
@MRC_LMS @ImperialMed
Our traditional Christmas dinner / secret Santa and once again a wonderful evening with Lymphocyte Development and Epigenetic Memory teams 🥳
@MRC_LMS @ImperialMed @imperialcollege
Lymphocyte Development & Epigenetic Memory Groups retweeted
Researchers @MRC_LMS @IreneYNadie @LymphDev show inducible genes and enhancers are regulated mainly by transcriptional burst frequency that this is coordinated in single cells and individual alleles and requires cohesin.
go.nature.com/3LDYNek
Lymphocyte Development & Epigenetic Memory Groups retweeted
Thrilled to see my 5 years of work finally published.
nature.com/articles/s41467-0…
Lymphocyte Development & Epigenetic Memory Groups retweeted
Researchers @LymphDev @MRC_LMS showed that a high-fat diet in mice can release silencing of the imprinted Dlk1 locus in subsequent generations via changes in microRNA expression.
go.nature.com/3Ib8zCI
Lymphocyte Development & Epigenetic Memory Groups retweeted
What a wonderful week with the @LymphDev and the @dpanne1 labs! Great science, new insights and lots of fun (and exploring the hills by bike)!
Lymphocyte Development & Epigenetic Memory Groups retweeted
And it’s a wrap! @LymphDev, Rowland and @dpanne1 joint lab retreat comes to an end with a visit to Grottes de Remouchamps. Great few days with this wonderful bunch- lots of science and fun (and Belgian beer)! – at Spa, Belgium
Lymphocyte Development & Epigenetic Memory Groups retweeted
This week we, @LymphDev, are in Spa, Belgium for a joint retreat with Daniel Panne (@dpanne1 @uniofleicester) and Benjamin Rowland (@NKI_nl) groups in this beautiful house
We are happy to announce that our research article entitled "Loss of H3K9 tri-methylation alters chromosome compaction and transcription factor retention during mitosis" is now out on bioRxiv: biorxiv.org/content/10.1101/…
@MRC_LMS @ImperialMed
