A group of chemists interested in the role of carbohydrates in (microbial) disease @IBCSinica. Opinions are my own.
Taipei, Taiwan
Joined January 2014
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Todd L. Lowary retweeted
🔬Publication - by Dr. Chun-Hung Lin @Brain1878
Newly identified #brain penetrant molecule #berbamine hydrochloride inhibits #Galectin 3, thereby improving symptoms of #neurological disorders such as #Huntington's disease. doi.org/10.1093/brain/awag06…
#bloodbrainbarrier #biochemistry
Todd L. Lowary retweeted
🔬Publication - by Dr. Jia-Wei Hsu
This study uncovered that #phosphoglycerate #kinase 1 (#PGK1) serves as co-#adaptor, stabilizes #AP2 complex, and enhances cargo recognition and #endocytosis. doi.org/10.1038/s44319-026-0…
#biochemistry #adaptor #protein #vesicle #biochem
Todd L. Lowary retweeted
🔬Publication - by Dr. Meng-Chiao Ho
The accumulation of #rice #ERFVIIs #transcription factor #SUB1A-1 achieves high #hypoxia tolerance through C-terminal associated #protein assembly under energy-limiting conditions. doi.org/10.1093/jxb/erag441
#agriculture #botany
Todd L. Lowary retweeted
🔬Publication - by Dr. Rita P.-Y. Chen @WileyGlobal
Using non-infectious #bovine #prion, this study shows how minor sequence differences contribute to conformational variability, #misfolding, and species transmission barriers. doi.org/10.1002/jccs.70221
#biochemistry #biochem
Todd L. Lowary retweeted
🔬Publication - by Dr. Hsin-Yung Yen @ACSPublications
A native MS platform utilizing #nanobodies was created to reveal structural diversity, distinct receptor conformations, and dynamic activation mechanisms at the #GPCR #intracellular interface. doi.org/10.1021/acs.analchem…
@biochem
Interesting paper. It's a pity the title is erroneous. The molecule used is a monosaccharide, not a polysaccharide. There is a difference, @angew_chem. Do better. @SebVidalChem @sjwill99
onlinelibrary.wiley.com/doi/…
Todd L. Lowary retweeted
IBC tenure-track faculty positions are now open!
👉Assistant Research Fellow level with experience in protein #biochemistry, structural #biology, #glycoscience and the study of other post-translational modifications.
For more information, please visit: sinica.edu.tw/recruitment_co…
Todd L. Lowary retweeted
🔬Publication - by Dr. Yung-Shu Kuan @WileyGlobal
During early #zebrafish development, transient #mTORC1 suppression requires select maternal and #zygotic #mRNA via #UTR elements #redd1 to ensure proper #gastrulation. doi.org/10.1111/febs.70521
#biochemistry #biochem #embryo
Todd L. Lowary retweeted
🔬Publication - by Dr. Yusuke Nasu @CellPressNews
Using a genetically encoded #glucose #biosensor, researchers demonstrated that #astrocyte support newborn #hippocampal #neurons through astrocytic glucose uptake and #lactate transport. doi.org/10.1016/j.neuron.202…
#biochemistry
Todd L. Lowary retweeted
🔬Publication - by Dr. Ruey-Hwa Chen
The long non-coding #RNA #Smyca is highly expressed in TNBC. It binds #FOXM1 to promote homologous recombination, suggesting Smyca as a potential target for sensitizing TNBC to #chemotherapy, #PARPi, or #immunotherapy. doi.org/10.1186/s12929-026-0…
Todd L. Lowary retweeted
🔬Publication by @Lowarylab @IDSAInfo
This newly developed invasive #aspergillosis #diagnostic assay detects free and extracellular vesicle-associated Galf-containing #glycans in #urine with monoclonal #antibody. doi.org/10.1093/infdis/jiag3…
#biochemistry #biohem
Todd L. Lowary retweeted
I am sorry to tell you that you have mistaken "alkylated" for "acylated" which indicate two different chemical bonds
@Lowarylab pointed this one to me recently
@J_A_C_S might want to look into this too ?
Todd L. Lowary retweeted
@cenmag maybe you could do something to fix this ?
Funny how this is NOT heparin in that drawing
Iduronic acid replaced by glucuronic acid
None of the anomeric centers are defined
That leave a lot of freedom for that synthesis uh
They used the @Wikipedia structure which is totally wrong
One more time #vidalized to understand
Todd L. Lowary retweeted
🔬Publication - by Dr. Peter Chi
This study unveils a new mechanism where #nucleostemin binds #DNA directly and interacts with #RAD51 to prevent the DNA from nucleolytic attack and #dsNDA break in stalled #replication forks. doi.org/10.1093/nar/gkag773
#biochemistry #biochem
Restore the historic American Chemical Society logo - Sign the Petition! c.org/TffXvpj5SS via @CdnChange
Todd L. Lowary retweeted
🔬Publication - by @Lowarylab @NatureComms
Mycobacteria usually competes with other #bacteria with #cell wall comprised of #peptidoglycan and so on, however, researchers found that endo-D-#arabinanase effector #is also part of its defense system. doi.org/10.1038/s41467-026-7…
#biochem
Todd L. Lowary retweeted
🔬Publication - by Dr. @asibc512
#Immunoglobulin κ-light chain (LC) is associated with LC #amyloidosis, and this study demonstrated that N-#glycosylation enhances LC secretion and accumulation outside the #cell. doi.org/10.1016/j.str.2026.0…
#biochemistry
Todd L. Lowary retweeted
🔬Publication - by Dr. Yusuke Nasu @NatureComms
This newly developed orange #calcium indicator provides an additional option for #neural activity visualization, while it demonstrates higher sensitivity, photostability, and signal-to-noise ratio. doi.org/10.1038/s41467-026-7…
#biochem
Todd L. Lowary retweeted
🔬Publication - by Dr. Manuel Maestre-Reyna
The newly developed dFoCC refinement method simplifies X-ray #diffraction technique, time resolved #crystallography, by using difference density maps to accurately deconvolve mixed state intermediate structures. doi.org/10.1002/2211-5463.70…
Todd L. Lowary retweeted
🔬Publication - by Dr. Po-Huang Liang @WileyGlobal
This study identified a structural mechanism for determining the substrate specificities of #GH5 multifunctional #cellulase/#hemicellulase, which are useful in converting plant biomass into #biofuel. doi.org/10.1111/febs.70610
