Professor @MDAndersonNews studying #metastasis & #immune response. @PKU1898 | @WeillCornellGS-@MSKCancerCenter | @WhiteheadInst alum. Views=own
Houston, TX, USA
Joined December 2021
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Our new paper in @ScienceTM: In vivo #CRISPR activation screen identifies acyl-CoA binding protein as a driver of #bone #metastasis. Super excited by this discovery! @ACS_Research @AmericanCancer @MDAndersonNews
science.org/doi/10.1126/scit…
A clinical study reveals why vaccines for meningococcus can partially protect against gonorrhea, CRISPR screens reveal a new treatment target in bone metastasis, and more in the new issue of #ScienceTranslationalMedicine. scim.ag/3SIKl8W
Li Ma, PhD retweeted
Leveraging #CRISPR activation screens, researchers identify the lipid metabolism protein ACBP as a key driver of bone metastasis, and show etomoxir or a ferroptosis inducer can prevent bone metastasis in mice. @LiMaCancerLab @MDAndersonNews scim.ag/4dAYFtY
🦴Our @ScienceTM study discovered ACBP as a metabolic driver of #BONE #metastasis.
🔬 Blocking fatty acid oxidation or inducing ferroptosis shuts down bone metastasis in vivo.
📰 @MDAndersonNews highlight:
mdanderson.org/newsroom/rese…
@ACKoongMDPhD @DraettaG @CarinHagberg
Bone metastasis remains a major clinical challenge. By identifying ACBP as a metabolic driver of this process and demonstrating the efficacy of targeting lipid metabolism in preclinical models, our work opens new therapeutic avenues for halting bone metastasis.
Hiring Postdoctoral Fellows for Cancer Metastasis & Immunotherapy research in my lab at MD Anderson! #PostdocJobs #CancerResearch @MDAndersonNews Apply: jobs.mdanderson.org/search/j…
Li Ma, PhD retweeted
#EveryCellIsAnImmuneCell! Deng @LiMaCancerLab &co show @NatMetabolism that during liver damage, LIFR drives production of CXCL1 by hepatocytes to recruit bone marrow neutrophils. LIFR also increases cholesterol secretion that makes neutrophils reparative! nature.com/articles/s42255-0…
1-Tweetorial for our @NatMetabolism paper on #metabolic and #immune regulation of tissue repair and #regeneration: rdcu.be/dQ4Za. In 2012, my lab at @MDAndersonNews reported that the cytokine receptor LIFR is a breast cancer #metastasis suppressor (Nat. Med. 2012).
16-Here, our findings reveal the mechanisms underlying injury-induced efflux of bone marrow neutrophils to the circulation and damaged liver, and uncover how reparative neutrophils signal to hepatocytes to proliferate in response to liver injury.
17-Kudos to the first author @Yalan_Deng and my entire team for their hard work and continued inspiration. Huge thanks to our collaborators, @Zhu_Lab, Michael Curran, and Chunru Lin, for sharing their resources and outstanding expertise.