Head of the Protease Pathophysiology Lab at the Bio21 Institute, University of Melbourne.
Melbourne, Australia
Joined June 2018
- Tweets221
- Following339
- Followers429
- Likes372
Laura Edgington-Mitchell retweeted
Online now! Advances in degradomics technologies to assess proteolytic cleavage events dlvr.it/TQjWrl #chembiol
Laura Edgington-Mitchell retweeted
Following #ASCO25, CEO @JSantini1 spoke with ONCOLife to discuss how abenacianine (VGT-309) is shining a light on #lungcancersurgery.
▶️ Watch: bit.ly/44M9vJv
#Innovation #OncologyInnovation #Biotech #ThoracicSurgery
Laura Edgington-Mitchell retweeted
The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.
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Laura Edgington-Mitchell retweeted
#News: Phase 2B VISUALIZE study results will be presented by @PennMedicine’s Dr. Sunil Singhal at #ASCO25, demonstrating that intraoperative molecular imaging with abenacianine for injection (VGT-309) during lung surgery has the potential to improve surgical outcomes.
More: bit.ly/439aILt
Laura Edgington-Mitchell retweeted
In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe, rapidly progressing genetic disease... all in an astounding 7 months. Best of all, the infant patient shows apparent benefit. Congratulations to @kiranmusunuru, Rebecca Ahrens-Nicklas, and other team members for this heroic and inspiring effort, which has implications for the hundreds of millions of patients that suffer from thousands of genetic diseases.
drive.google.com/file/d/1Jfk…
Laura Edgington-Mitchell retweeted
We also show that Coxiella incites the extracellular secretion of lysosomal content in a T4SS-independent manner.
A wonderfully enjoyable collaboration with @LauraEM_Lab & @hayleyjnewton labs (with significant mass spec guidance from @Nick_E_Scott!)
@TheDohertyInst @UniMelbMDHS
Laura Edgington-Mitchell retweeted
Excited to share this story from my PhD, out today in
@NatureComms. We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB.
nature.com/articles/s41467-0…
Laura Edgington-Mitchell retweeted
We’re thrilled to welcome our 14th Snow Fellow, Dr Alisa Glukhova @gl_alisa, a structural biologist from @WEHI_research. Alisa’s work focusses on how cells communicate and what happens when those signals go wrong, leading to diseases like cancer.
snowmedical.org.au
Laura Edgington-Mitchell retweeted
Incredibly excited to share Dr Alisa Glukhova has been awarded a prestigious @SnowMedical Fellowship - the only recipient this year!
She'll receive $8M over 8 years to advance her groundbreaking #cancer research. Congrats @gl_alisa
#medicalresearch
🔗 wehi.edu.au/news/wehi-cancer…
Laura Edgington-Mitchell retweeted
Prof. Matthew Boygo, expert in chemical proteomics, to give plenary talk at MCCB 2025! Don't miss this chance to learn from a visionary.
🔗 bit.ly/4hb6pEl
#RACI #ozchem #BOD1640
Laura Edgington-Mitchell retweeted
We are hiring!
Join @VerdoesLab at the @LUMC_Leiden Immunology department to apply chemistry to pioneer the next generation cancer vaccines:
linkedin.com/posts/oncode-ac…
Laura Edgington-Mitchell retweeted
My lab has an open post-doc position in Organic Synthesis & Chemical Biology with a focus on membrane proteins in synapses. Apply before the end of August 2024. See: kuleuven.be/personeel/jobsit…
Laura Edgington-Mitchell retweeted
🥳 We are excited to share our most recent paper, ‘Spatial resolution of the head and neck cancer tumor microenvironment to identify tumor and stromal features associated with therapy response’ doi.org/10.1111/imcb.12811. Let's dive into the key highlights! [1/9]
Laura Edgington-Mitchell retweeted
Thrilled to share our MultiMap paper is now published online on Science. @ScienceMagazine With @realJimWells, we present a multiscale photocatalytic proximity labeling platform for interactome profiling. science.org/doi/10.1126/scie…
Laura Edgington-Mitchell retweeted
Phase 2 data published in @STS_CTsurgery journal @annalsthorsurg show VGT-309 may help surgeons see difficult-to-find and previously undetected tumors in real-time during #MIS and robotic-assisted surgery.
bit.ly/4bNYCIE
#TumorVisualization #LungCancer
Laura Edgington-Mitchell retweeted
I wouldn't normally tweet about a PK/PD paper but this is interesting data. Analysis of exacerbations in bronchiectasis patients treated with Brensocatib in a phase 2 study. Blue: sputum neutrophil elastase became undetectable on treatment, Red it didn't.
link.springer.com/content/pd…
Laura Edgington-Mitchell retweeted
New Research: The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species #pharmacology frontiersin.org/articles/10.…
Laura Edgington-Mitchell retweeted
Physical location within a cell can influence #BiasedSignaling as much as, if not more so than, the conformation of the receptors involved, according to new work that could inform research into more selective therapies that target #GPCRs. @SciSignal scim.ag/7DU
Laura Edgington-Mitchell retweeted
For all ubiquitin, deubiquitinase and chemical biology aficionados:
Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains.
t.ly/GnRVv
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