@LanderLab

https://xitter.cf/t.co/bRCIwbP1FJ

 La Jolla, San Diego
lander-lab.com
Joined January 2014
  • Tweets832
  • Following346
  • Followers5.4K
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Last chance to apply to the Cold Spring Harbor #cryoem course this March (application deadline is Jan 15th)! Learn all about sample prep, microscope operation, and image processing at this fun 2-week course @kollmanlab @Jen_Cash_11 @cshlcourses meetings.cshl.edu/courses.as…

Cryo-Electron Microscopy

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu
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Congrats to our grad students who pitched therapeutic targets at this year's @ScrippsGradPrgm Drug Discovery Shark Tank - particularly Shelby @ShelbyFerrier and Morgan @m_m_gee on their winning proposal to target Cholera toxin subunit B, which raised $4 million!
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Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ @G__Napolitano, A. Esposito, and A. Ballabio.
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You can now follow us at bsky.app/profile/landerlab.b…
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The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! biorxiv.org/content/10.1101/…
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Replying to @AlanRoseman3 @jhschaef
Mystery solved. And fascinating! Thanks Alan
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Let us know if you recognize this complex
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Replying to @mimi1inh @scrippsresearch
My bench skills are long gone…
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Proof our lab skills are cutting-edge—both at the microscope and the (pumpkin carving) bench! 🎃🔬 #CryoEM #PumpkinScience @scrippsresearch
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Ready for the final day of the BPS meeting on 'Emerging Theoretical Approaches to Complement Single-Particle Cryo-EM' in Trieste! 🔬 We had outstanding speakers, great science, and friendly atmosphere. Thanks to @BiophysicalSoc @cecamEvents, @palermo_lab @RommieAmaro @LanderLab!
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Apply now and come work at @VanderbiltU with me and my outstanding colleagues in the Center for Structural Biology! Would be thrilled to recruit more #NMR friendly colleagues! 😉🙌 @VanderbiltCSB @VandyBiochem @VUBasicSciences
Vanderbilt Center for Structural Biology@VanderbiltCSB18 Sep 2024
The @vanderbiltfirst application for tenure-track faculty positions in Structural Biology & Imaging or Genetic and Omic Discovery & Health Disparities is open. Priority deadline to apply is Nov 4! More info: vanderbiltfirst.com/open-pos… #postdocjobs #BlackInBiophysics
https://vanderbiltfirst.com/open-positions/

ALT https://vanderbiltfirst.com/open-positions/

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Lander Lab retweeted
ludo@ludovic_autin18 Sep 2024
Mesoscale Explorer molstar.org/me/ Paper out !! Excellent work with @asrmoin @dsgoodsell  and @sehnaldavid doi.org/10.1002/pro.5177
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Some thoughts on the current state of single particle cryo-EM map/model validation. (TLDR: preferred orientation remains a big problem, ❤️ Q-scores. There's been progress, but there's still more to do. ) authors.elsevier.com/sd/arti…
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The registration deadline of the meeting "Emerging theoretical approaches to complement single-particle cryo-electron microscopy" is today! Join us in Trieste, Italy, with an outstanding list of speakers. biophysics.org/2024trieste#/ Pls RT & Apply !
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Replying to @GonenShane @jzhaosbp
Grid factory set up in La Jolla thanks to @RubinsteinJohn & @jzhaosbp! Efforts spearheaded by @lalexandrescu1, carbon or gold with a bunch of different hole sizes and spacing. Come by any time @GonenShane !
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We always thought nucleotide state strictly defined AAA+ conformation, but Jeff Mindrebo's work on mito LONP1 suggests more is at play - substrate interactions also drive protein translocation! Revisiting & rethinking the hand-over-hand mechanism: tinyurl.com/49y7a6h6
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Replying to @CrollTristan
Finally getting around to using this, very pleased with the implementation. Thanks Tristan! Is it possible to color the residues according to Q-score like in the OG Chimera plugin?
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Hey all new(ish) structural biology PIs out there - I started a slack workspace geared toward us! If you’d like to join, DM me your email and method(s) of choice, and I’ll add you to the group.
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We were incredibly disappointed with the lack of code or executable accompanying the publication of AF3 in @Nature . This contradicts scientific principles of the ability to evaluate, use, and build upon existing work. zenodo.org/records/11179894

AlphaFold3 Transparency and Reproducibility

Link for endorsement signatures: https://forms.gle/d47w29eGHeL1ejXw9

zenodo.org
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There is no such thing as AlphaFold3. There is only alphafoldserver.com. The difference is throttling rigorous scientific and biomedical research.
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