@LabZhu

The Zhu lab studies the moon/tide-related 12h ultradian clock; xbp1, proteostasis, epigenetic, metabolism, aging, stress response are the key words. @AgingPitt

 Aging Institute, Divison of Endocrinolog…
bzhulab.com/
Joined June 2018
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  • Following853
  • Followers517
24Media
Bokai Zhu lab retweeted
James Howe@jamesrhowe6Oct 6
The wildest part of the Nobel drama is that the least-discussed guy left out, Zhuo-Hua Pan, has a better claim on the tech than Boyden and he’s the only one with any shot of turning opto into a real therapy….he just wasn’t at a prestigious institution statnews.com/2016/09/01/opto…

He may have invented one of neuroscience’s biggest advances. But you’ve never heard of him

The saga of Zhuo-Hua Pan, perhaps the rightful inventor of optogenetics, raises the question of what it means to invent something in science.

statnews.com
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Bokai Zhu lab retweeted
Salma Kaochar
@Kaochar211 Nov 2025
Sadden to hear the passing of Dr. Bert O’Malley, the father of molecular endocrinology, a long-time mentor, and friend.
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Bokai Zhu lab retweeted
ShorterLab@ShorterLab24 Sep 2025
Collective homeostasis of condensation-prone proteins via their mRNAs: nature.com/articles/s41586-0…

Collective homeostasis of condensation-prone proteins via their mRNAs

Nature - The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own...

nature.com
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Bokai Zhu lab retweeted
Aydogan Lab@AydoganLab25 Aug 2025
#Postdoc opportunity at Columbia U. in New York! We are interested in candidates from biochemistry backgr. & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. w/ @Aydinlab at NYU! hhmi.wd1.myworkdayjobs.com/E…
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LYVAC/PDZD8 is a lysosomal vacuolator | Science science.org/doi/10.1126/scie…

LYVAC/PDZD8 is a lysosomal vacuolator

Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–a...

science.org
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Bokai Zhu lab retweeted
Qi Chen
@qichen_lab20 Aug 2025
Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation @NatureCellBio, where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA.🧵 rdcu.be/eBwPJ
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ShorterLab@ShorterLab13 Aug 2025
A multichaperone condensate enhances protein folding in the endoplasmic reticulum: nature.com/articles/s41556-0…

A multichaperone condensate enhances protein folding in the endoplasmic reticulum

Nature Cell Biology - Leder et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing...

nature.com
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Antiparasitic Drug Shows Power Against Alzheimer’s and Dementia today.ucsd.edu/story/antipar…

Antiparasitic Drug Shows Power Against Alzheimer’s and Dementia

UC San Diego researchers have helped discover that a drug used to treat pinworms, can be repurposed to rejuvenate cellular structures and potentially treat neurodegenerative diseases like Alzheimer's...

today.ucsd.edu
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Excited to see the work by @Yale_INP students Suzhou Yang @Denethi_W w/ collabs @YaleNeuro iPSC core @jdpereira @ArabTanina and @MayoClinicNeuro @gendron_tania @NeuroUdit on #C9orf72 #ALS & #FTD finally out in @NatureNeuro! @WuTsaiYale @KavliAtYale nature.com/articles/s41593-0…

Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD

Nature Neuroscience - By selectively isolating and sequencing the rare RNA transcripts containing C9orf72 repeat expansion from ALS–FTD neurons, the authors uncover an alternative splicing...

nature.com
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Bokai Zhu lab retweeted
Samuel Hume
@DrSamuelBHume6 Feb 2025
This is like AlphaFold, but for protein localisation rather than folding It's a deep learning model that predicts a protein's subcellular compartment based on its amino acid sequence alone:
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The Aging Institute is pleased to share the most recent edition of our newsletter, The Chronos Chronicle, Winter 2025. Read more about the exciting research happening at the Aging Institute here: aging.pitt.edu/newsletter-wi…
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Aydogan Lab@AydoganLab30 Oct 2024
🚨Pre-print Alert!🚨 THRILLED to share our new story with MANY unexpected turns, leading us into territories entirely new to the lab! *A mitochondrial redox switch licences the onset of morphogenesis in animals* A detailed🧵on it will follow soon!! biorxiv.org/content/10.1101/…

A mitochondrial redox switch licenses the onset of morphogenesis in animals

Embryos undergo pre-gastrulation cleavage cycles to generate a critical cell mass before transitioning to morphogenesis. The molecular underpinnings of this transition have traditionally centered on...

biorxiv.org
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The 2024 Nobel Prize in Literature has been awarded to ChatGPT for democratizing the creative process and freeing the written word from humanity’s limitations.
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Bokai Zhu lab retweeted
Jay Tan@JayXiaojunTan20 Sep 2024
🦕Welcome to the Jurassic era of STING! Online @MolecularCell We uncovered a primordial role of the cGAS-STING pathway in lysosomal biogenesis & stress clearance, revealing its ancient function predating type I interferons. authors.elsevier.com/a/1joCM… Kudos to Bo Lv & coauthors!! 1/n
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📰New study in @MolecularCell from @AgingPitt researchers including @JayXiaojunTan and @LabZhu suggest STING may play a major role in aging. Read more: inside.upmc.com/double-edged…

Double-Edged STING: Pitt Study Identifies New Pathway Involved in Aging - UPMC & Pitt Health...

A protein called STING, previously shown to control a pathway… Read more

inside.upmc.com
Molecular Cell@MolecularCell19 Sep 2024
Online Now: A TBK1-independent primordial function of STING in lysosomal biogenesis dlvr.it/TDRjZt
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Bokai Zhu lab retweeted
Dongyin Guan@DongyinGuan6 Sep 2024
We received 265 attendees per lecture in the summer seminar series. Now, we have finalized the speaker list and presentation dates for this upcoming fall seminar series. We continue to look forward to exciting science and inspiring discussions.
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Our aging paper just came out. Two periods of major changes: Mid 40s and 60s. Check it out doi.org/10.1038/s43587-024-0…

Nonlinear dynamics of multi-omics profiles during human aging

Nature Aging - Understanding the molecular changes underlying aging is important for developing biomarkers and healthy aging interventions. In this study, the authors used comprehensive multi-omics...

nature.com
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Let's talk about Healthy Aging. So much to do in this growing field. AGE has been on my mind lately, since we are almost at the end of my birthday month! @NIHAging @BuckInstitute @scifri @Radiolab
Science Friday@scifri24 May 2024
Aging often looks very different for different people. @healthspan_AUG joins us to discuss a new study that identified certain metabolites as reliable markers of biological age and the implications of better understanding a person’s biological age. sciencefriday.com/segments/m…

Your ‘Biological Age’ Could Be Different Than How Old You Are

Metabolic markers could eventually result in a test for “biological age,” which considers how things other than time age the body.

sciencefriday.com
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Bokai Zhu lab retweeted
bioRxiv@biorxivpreprint11 May 2024
Extensive folding variability between homologous chromosomes in mammalian cells biorxiv.org/cgi/content/shor… #bioRxiv
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Bokai Zhu lab retweeted
ShorterLab@ShorterLab8 May 2024
Genome organization around nuclear speckles drives mRNA splicing efficiency: nature.com/articles/s41586-0…
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