Researcher broadly examining how DNA and RNA epigenetics dynamically regulate gene expression. All views are my own
Bethesda, MD
Joined January 2019
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The Oberdoerffer lab is expanding in size and scope! Please apply if you are interested in pursuing a postdoc in RNA modifications and the development of cancer therapeutics.
nature.com/naturecareers/job… #jobs
We are looking for a postdoctoral fellow to join our talented team exploring mRNA modifications and translation regulation. This is a fully funded position on the vibrant NIH main campus. Please RT and DM for more info. tinyurl.com/2ecbjxka
Thanks for profiling our work @epigenie! Location matters in the epitranscriptome, @MolecularCell. bit.ly/3poemMD
An exciting epitransciptomic study led by cunning cartographers from the @LabShalini reports that “Location, Location, Location” impacts translation through site-specific ac4C acetylation of messenger RNA thanks to the development of a sensitive new assay. bit.ly/3Ozz3Ab
ALT A team of cunning cartographers led by Shalini Oberdoerffer (National Cancer Institute, NIH) previously reported an acetylated RNA immunoprecipitation method and demonstrated how the N4-acetylcytidine (ac4C) modification in mRNA coding sequences enhanced translational elongation by improving interactions with transfer RNAs. https://epigenie.com/location-location-location-how-site-specific-mrna-ac4c-acetylation-impacts-translation/
Thrilled to share our latest work. Base-resolution analysis of ac4C in human mRNA reveals a site-specific role in translation initiation. Beautiful cryo-EM analysis from the #NCI CMM. Congrats to all authors esp. @Dany_bioArango and @dave_sturgill. cell.com/molecular-cell/full…
Shalini Oberdoerffer retweeted
"The world’s first tRNA platform company"? A debatable claim, with so many startups actively aiming to turn transfer RNAs into drugs: nature.com/articles/s41587-0…
@TevardB @ShapeTx @alltrna @ReCodeTx
@LeslieJWilliams @chrisahern @ArcturusRx @jmcoller @afzelius_lovisa @NatureBiotech
Thrilled to be a part of this great line-up and looking forward to meeting in California this November!
Please join us at our RNA at the Bench and Bedside III meeting in San Diego (or virtually) Nov 8-10 2022 co-organized by the Nature editors, Stan Crooke and myself! conferences.nature.com/RRx15…
Shalini Oberdoerffer retweeted
From Feb issue cover
#Review from Passmore&Coller detailing Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression
@lapassmore @MRC_LMB @jmcoller
#GeneExpression #mRNAdecay #translation #PolyA
Check it out here: go.nature.com/3iBYqD
RNA modification, translation, aging, metabolism folks- you have to read this one. It has it all. My perception of ribosomes is fundamentally altered. biorxiv.org/content/10.1101/…
Congratulations!
Announcing lab (re)opening - more bland than grand in these pandemic times - @JohnsHopkins, Department of Rad/Onc & Molecular Radiation Sciences - coming October 1st! Check us out at bit.ly/3kpUl5I for more info - and come visit when safe!
Final lab lunch with my soon-to-be former postdoc @Dany_bioArango. For trainees interested in the #epitranscriptome, I highly recommend the new Arango lab @NUFeinbergMed. We will miss you Danny!
Shalini Oberdoerffer retweeted
I wrote this article for my own catharsis. I never expected it to be peer reviewed. When @NEJM accepted it, I experienced my first panic attack. 1/
@WomenInMedicine @WomeninOnc @AMWADoctors @womeninmedchat @WomeninAcademi1
Provocative thought herein- ribosomal RNA modifications can mediate the translation of specific mRNAs. Congratulations @SiggyN5 and team!
Excited to share our preprint about the METTL5-TRMT112 methyltransferase complex. Kudos to all involved for wrapping this up across multiple time zones during a pandemic, no easy feat! @CDRE_CEGS @UChiChemistry
biorxiv.org/content/10.1101/…
In case you have wondered what happens when ribosomes collide on 5'UTRs- some answers here. Very nice from @ebennettlab.
Thought ribosome collisions occurred only during elongation? Check out our latest work - iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation biorxiv.org/content/10.1101/… - Congrats to @DGarshott #crushingit
Shalini Oberdoerffer retweeted
After much hard work from @RamamurthiLab our latest exploration of the evolution&biochemistry of P-loop NTPases is out. Here we attempt reconstructing changes that might 've transformed an Era-like translation GTPase into an ATPase structural protein elifesciences.org/articles/6…
This is a great opportunity for RNA/molecular biologists interested in making the leap to translational research.
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This was a fun read- polylysine synthesis in the absence of protein and mRNA. Definitely raises some intriguing downstream applications....
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The Oberdoerffer lab is feeling good about 2021! We’re looking to hire 1) a Staff Scientist in mRNA modifications/Computational Biology and 2) a shared postdoc to study mRNA de-regulation in aging with the Ferrucci lab. Please RT and DM for info!
ccr.cancer.gov/careers/staff…