Scorrano Lab @DiBio_UniPD & @VIMMPadua. We study #mitochondria #celldeath #contactsites #metabolism #cristae #Opa1. Luca's tweets are signed LS

Padua, Italy
Joined September 2018
🚨Exciting Opportunity!🚨 The University of Udine is recruiting researchers for a project on Spinal Muscular Atrophy (SMA), focusing on pioneering microRNA (miRNA) therapies. 📩 Reach out to Dr. Camilla Bean for details: [email protected] Please repost!
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In the liver, Ermit2 facilitates ER-mitochondria phospholipid transfer, reduces ER stress caused by Mfn2 ablation and in models of NASH. Molecularly, Ermit2 CC2 domain is required to interact with CC1 and CC2 of mitochondrial Mfn1&2, in a complex apt to stabilize ER-mito 4/
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Ermin2 and Ermit2 do not influence mitochondrial morphology. Ermin2 regulates ER shape and luminal connectivity. Ermit2 is enriched in MAMs. Ermit2 increases ER-mito proximity measured by ddGFP, FEMP, EM. In cells, Ermit2 supports Ca2+ transfer from ER to mitochondria 3/
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Mfn2 tethers ER to mitochondria, but what's its partner on the ER? How does it tether heterotypic organelles without fusing them? Deborah discovered that Mfn2 is alternatively spliced in two variants Ermin2 and Ermit2 that lack the GTPase domain and go only to the ER. 2/
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I know that you were waiting for the moment when MitoLisa, the prize for the Margaret Lewis award, was unveiled. Here she is, in full splendor, in my office @VIMMPadua. Note the lipid droplets and ER, her mito carnation, her nose-shaped cristae! A masterpiece, a milestone! LS
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We are very happy and proud that Luca was recognised with the very first Margaret Lewis award for the recognition of excellence in the mitochondria biology field @GordonConf
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Scenes from the (in)famous lab xmas dinner… Happy holidays from all of us!
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We’re still here and ready to join wherever 😉
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Few members from the lab enjoying the @CellSymposia in #Sevilla over the past days @AkikoOmori2 @SatokoS_PhD @AnnaPellattiero @mau_carr
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