@LabRanjith

Physical Biology Lab @BsbeIitb @iitbombay. Interests: Chromatin assembly, dynamics, protein self-assembly. PI: @ranjithpa. Managed by Lab members

 Mumbai
Joined May 2021
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Recent work from our group: Role of diffusion and reaction of the constituents in spreading of histone modification marks biorxiv.org/content/10.1101/…

Role of diffusion and reaction of the constituents in spreading of histone modification marks

Cells switch genes ON or OFF by altering the state of chromatin via histone modifications at specific regulatory locations along the chromatin polymer. These gene regulation processes are carried out...

biorxiv.org
Vinoth@vinoth46m26 Dec 2023
What is the role of diffusion of enzymes/other constituents in the spreading of histone modifications? We simulated a model with diffusion and reaction of reader/writer enzymes to explain the spreading of histone modifications. biorxiv.org/content/10.1101/… (1/5)
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Our work is out in @NatureComms. Read the paper if you want a quantitative description of chromatin polymer or plan to simulate chromatin. We answer some fundamental questions. Details below. @sangramjkadam @KiranKumari_ @vinoth46m @DuttaShuvadip @mithunmittir (1/10)
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Exciting work from our lab in @PLOSCompBiol on histone modification inheritance, post replication. With collaboration with Prof.Sibiraj Pillai from the electrical department IIT Bombay. Congratulations @nitkal and @ranjithpa.
Nithya Ramakrishnan@nitkal18 Feb 2022
Our work, modeling the high fidelity inheritance of histone modifications post replication, using ideas from information theory, is published in PLOS computational biology. journals.plos.org/ploscompbi… @ranjithpa

High fidelity epigenetic inheritance: Information theoretic model predicts threshold filling of...

Author summary Chromatin is essentially the DNA that is folded and packaged with the help of proteins. While the nucleotide sequence in the DNA codes genetic information, the packaging of the DNA...

journals.plos.org
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📣📣📣Excited to announce the launch of a new research topic in @FrontMolBioSci Molecular determinants of protein assemblies in health and disease frontiersin.org/research-top… Submission Open @PPMC_UAB @_VerenaKohler @AdityaRanganat4 #proteinaggregation #biomolecularcondensates
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Interesting work from our lab alumnus @AdityaRanganat4 on RNA-binding protein condensates and emergence of fibrillar structures using coarse-grained simulations.
Srivastav Ranganathan@AdityaRanganat419 Nov 2021
biorxiv.org/content/10.1101/… RNA-binding protein condensates exhibit a physical phenomenon called aging which results in a loss of dynamicity. We use coarse-grained simulations to show that droplets can access several structural states with distinct intra-condensate environments.

Emergence of order in condensates composed of multi-valent, multi-domain proteins

Many RNA-binding proteins (RBPs) that assemble into membraneless organelles, have a common architecture including disordered prion-like domain (PLD) and folded RNA-binding domain (RBD). An enrichment...

biorxiv.org
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Congratulations Prof. Rohit Srivastava @rsr004 on winning the prestigious SS Bhatnagar Prize in medical sciences. Proud moment for all of us @BsbeIitb @iitbombay
CSIR, India
@CSIR_IND26 Sep 2021
Hearty Congratulation to Dr. Rohit Srivastava of @iitbombay on winning the Shanti Swarup Bhatnagar Prize (SSB) for Science and Technology 2021 (Medical Sciences) @DrJitendraSingh @shekhar_mande @mygovindia @PIB_India
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Congratulations to our former lab colleague Jyotsana for being part of this interesting work. @Jewelparmar @NCBStheory
Jewel Parmar@Jewelparmar17 Aug 2021
Delighted to share the preprint of our collaborative work with @Afroze_AC @dnarepairlab at Simon's center @NCBStheory. Chech out the preprint showing the role of SMC protein RecN in the repair process during dsDNA breaks in bacteria.
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Congratulations!! We are happy for our lab alumna Jyotsana Parmar for receiving the DST Inspire faculty fellowship. @Jewelparmar @IndiaDST @ranjithpa online-inspire.gov.in/
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Our labmate @KiranKumari_ receiving PhD degree. Congratulations Kiran! It is great to see your avatar in convocation robe and receiving the degree! Proud of you! Cheers and best wishes! @BsbeIitb @iitbombay @iitbmonash
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Hello World!
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