@LabManoli

Understanding the neurobiology of attachment. @UCSFPsychiatry

manolilab.ucsf.edu/
Joined April 2021
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  • Following168
  • Followers261
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Prairie voles that don't have oxytocin receptors still bond and parent, as we (@UCSFPsychiatry and @UCSF), @BalesLab & @Shah_Laboratory show in @NeuroCellPress authors.elsevier.com/a/1gUwg…
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One Mind
@OneMindOrg20 Apr 2023
📢🧠 Applications for the 2023 One Mind Rising Star Awards are open! Learn more about and how to apply for our $300K grants supporting early-career neuroscience and psychiatry investigators who are working to accelerate #mentalhealth breakthroughs: onemind.org/rising-star-awar…
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High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways dlvr.it/Sl4Dmb
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Dena Dubal
@DenaDubal10 Feb 2023
Attn FEMALE ‘MENTORS’: Young Female mice exposed to Odor of older female mice live longer. elifesciences.org/digests/84…

Smells like old age

Young female mice exposed to scents from older females live longer.

elifesciences.org
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One Mind
@OneMindOrg30 Jan 2023
Exciting new research update from 2018 One Mind @JanssenUS Rising Star Awardee Dr. Susanne Ahmari sheds light on brain activity in #BingeEating disorder and uncovers a potential treatment target. Congrats @ahmari_lab! Read more: pubmed.ncbi.nlm.nih.gov/3668…
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Our latest! Led by @nathanCSharris & Sam Bates we ask: How do experiences modify neuronal gene expression to drive plasticity? We find that multiple stimulus features can be encoded in the gene expression program of a single sensory neuron.. 1/13 biorxiv.org/content/10.1101/…

Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and...

Neurons modify their transcriptomes in response to an animal’s experience. How specific experiences are transduced to modulate gene expression and precisely tune neuronal functions are not fully...

biorxiv.org
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1/ 🧵I’m excited to announce new work from the Clowney lab, led by @mariaahmedch. Maria re-engineered the neuronal constituents and connectivity of an “expansion layer” to ask how quantitative properties of circuit wiring structure perception. biorxiv.org/content/10.1101/…

Hacking brain development to test models of sensory coding

Animals can discriminate myriad sensory stimuli but can also generalize from learned experience. You can probably distinguish the favorite teas of your colleagues while still recognizing that all tea...

biorxiv.org
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Steve Shea@sheacshl31 Jan 2023
New science from Shea Lab: "Selective deletion of Methyl CpG binding protein 2 from parvalbumin interneurons in the auditory cortex delays the onset of maternal retrieval in mice" by @dcarrot2 with a major assist from @PagliaroAlexa biorxiv.org/content/10.1101/…

Selective deletion of Methyl CpG binding protein 2 from parvalbumin interneurons in the auditory...

Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome. MECP2 codes for methyl CpG binding protein 2 (MECP2), a transcriptional regulator that activates genetic programs for experie...

biorxiv.org
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#Oxytocin—a hormone long considered essential to social bonding—may not be as critical as originally thought. “While oxytocin has been considered ‘Love Potion #9,’ it seems that potions 1 thru 8 might be sufficient,” Dr. Devanand Manoli (@LabManoli) says. ucsfh.org/3HE7FA7
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.@labManoli is calling the role of #oxytocin into question. In a new study with @BalesLab and @Shah_Laboratory, they showed prairie voles without oxytocin receptors can bond, give birth, and feed their young ucsfpsy.ch/3HEFIs8 @UCSF #UCSFWeill
Devanand Manoli, MD, MS

ALT Devanand Manoli, MD, MS

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Bales Lab@BalesLab28 Jan 2023
We're very excited and happy that this collaboration is now out in the world! thanks @LabManoli @Shah_Laboratory
Manoli Lab@LabManoli27 Jan 2023
Prairie voles that don't have oxytocin receptors still bond and parent, as we (@UCSFPsychiatry and @UCSF), @BalesLab & @Shah_Laboratory show in @NeuroCellPress authors.elsevier.com/a/1gUwg…
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Congratulations, Dev, Nirao, Maricruz, Yichao, Srini, and the team on this epoch-making paper! 🎉🎉🎉 @LabManoli @NiraoShah @amaricruz3_a @YichaoWei sciencedirect.com/science/ar…
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One Mind
@OneMindOrg27 Jan 2023
Thought-provoking research from 2021 One Mind @JanssenUS Rising Star Awardee Dr. Devanand Manoli suggests that it may be time to reevaluate long-held hypotheses about the role of oxytocin in some forms of social attachment. Congrats, @LabManoli! Read more: sciencedirect.com/science/ar…
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Oxytocin receptor is not required for social attachment in prairie voles cell.com/neuron/fulltext/S08… The tragedy of Science-the slaying of a beautiful hypothesis by an ugly fact (Huxley?). Been on the other side and know how much it stinks-but this is why we do science!

Oxytocin receptor is not required for social attachment in prairie voles

Berendzen et al. report the surprising finding that prairie voles lacking the oxytocin receptor (Oxtr) display pair-bonding and parental behaviors, including nursing. Despite many pharmacological...

cell.com
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Prairie voles can form pair-bonds and rear pups without oxytocin receptor signaling, contrary to decades of research stating otherwise. Read more in @NeuroCellPress: cell.com/neuron/fulltext/S08… @LabManoli @Shah_Laboratory
Nastacia Goodwin

ALT Nastacia Goodwin

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Excited to share my lab’s new paper out today @CellCellPress. "Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity" Congratulations to this amazing team of scientists. cell.com/cell/fulltext/S0092…
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Extremely honored for this. Thanks to my lab, IHG members and staff and so many people at UCSF! Looking forward to advancing the IHG and genetics and genomics research at UCSF!
Institute for Human Genetics at UCSF@IHG_at_UCSF23 Jan 2023
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You know Valentine’s Day is rapidly approaching when prairie voles are in the news again! Here’s a piece by @evolbrain @LabManoli and me to get you ready for the upcoming celebration of love with a little (ok not so little) side helping of science! scientificamerican.com/artic…

Monogamous Prairie Voles Reveal the Neurobiology of Love

Studies of prairie voles are providing surprising new insights into how social bonds form

scientificamerican.com
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biorxiv.org/content/10.1101/… Very excited to share the work of Kristen Berendzen and Ruchira Sharma and our collaborators in the @BalesLab and @Shah_Laboratory Strikingly, we find the oxytocin receptor is NOT required for partner preference or parenting behaviors in prairie voles.

Oxytocin receptor is not required for social attachment in prairie voles

Prairie voles are among a small group of mammals that display long-term social attachment between mating partners. Many pharmacological studies show that signaling via the oxytocin receptor (OxtR) is...

biorxiv.org
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Their work really shows the power of genetics and that the brain can be wired for bonding during development without OxtR function even when acute disruptions of the pathway in adults dramatically interferes with it.
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