@LabLamba

Lamba lab focuses on leveraging human stem cell technologies for retinal repair and modeling disease-in-a-dish to develop novel therapeutics.

 UCSF, San Francisco, CA
Lambalab.ucsf.edu/
Joined April 2021
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  • Following93
  • Followers244
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Recently published: Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel. @YuChingtzu, @LabLamba, @MCW_CBNA @MartinPeraJAX #retinaldegeneration #stemcells #iPSCs #animalmodels ow.ly/Iz3x50QAj49
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Congratulations to our @LabLamba postdoc @KandoiSangeetha on receiving the @_BrightFocus postdoctoral felowship on Macular Degeneration Research for her project on the hibernating cone-dominant 13-lined ground squirrel as a model for macular degeneration.
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Sangeetha Kandoi, Cassandra Martinez Dana K. Merriman & Deepak A. Lamba @LabLamba @ucsfhealth study embryonic and postnatal development of the 13-Lined Ground Squirrels retina. doi.org/10.1167/tvst.11.11.1…
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Congratulations to @KandoiSangeetha on being the people's choice winner at the UCSF postdoc slam! Outstanding job!! So proud of your accomplishment!
Graduate Education and Postdoctoral Affairs@UCSFGradDiv19 Sep 2022
Don't Miss UCSF Postdoc Slam! The ten postdoc finalists are getting ready - are you? Tune into the livestream Weds Sep 21, 4 p.m. PT. postdocs.ucsf.edu/watch-post… @UCSF_Postdocs @PostdocsUCSF #UCSFPostdocSlam #UCSFnpaw #NPAW2022
Grid of photos of 10 Postdoc Slam finalists, with tagline "Tune in for Postdoc Slam 2022"

ALT Grid of photos of 10 Postdoc Slam finalists, with tagline "Tune in for Postdoc Slam 2022"

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We have another manuscript up based on some amazing pain-staking work over a few years by @small_crane in the lab. Her final hurrah from the lab prior to embarking on her grad school experience. So proud of her! biorxiv.org/content/10.1101/…

Timed Notch Inhibition drives Photoreceptor fate specification in Human Retinal Organoids

Purpose Transplanting photoreceptors from human pluripotent stem cell derived retinal organoids have the potential to reverse vision loss in affected individuals. However, transplantable photorecep...

biorxiv.org
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We still have open positions in the @LabLamba for postdocs interested in iPSC-based disease modeling. Anyone interested in growing mini human retinas for developmental or disease modeling please DM me or email me at deepak.lamba@UCSF.edu
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Characterization of retinal development in 13-lined ground squirrels biorxiv.org/content/10.1101/…

Characterization of retinal development in 13-lined ground squirrels

Purpose The cone-dominant, 13-lined ground squirrel (13-LGS) retina mimics the human foveal region but retinal development in this useful rodent species has not been reported. Here, the embryonic and...

biorxiv.org
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Happy to announce publication for @LabLamba new paper by our outgoing grad student Josh Karmer looking at the evolutionary conservation of Dpp/TGFβ-superfamily in retinal damage response in Drosophila and mice #PLOSONE dx.plos.org/10.1371/journal.…

Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina

Retinal homeostasis relies on intricate coordination of cell death and survival in response to stress and damage. Signaling mechanisms that coordinate this process in the adult retina remain poorly...

journals.plos.org
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Replying to @ardemp @NIH
NIH study sections truly are the great equalizer!
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In our work out in @Cellreports we have made significant strides in regenerating neurons from glia. We find the combination of Ascl1 with Atoh-transcription factors significantly improves the ability of Muller glia to regenerate neurons. cell.com/cell-reports/fullte… Quick summary:

Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of...

Endogenous regeneration strategies hold great therapeutic promise for degenerative diseases of the nervous system. In this report, Todd et al. demonstrate that combinations of proneural transcription...

cell.com
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Extremely excited to share work from our post-doc @_DrKatieRose on modeling LCA7 using retinal organoids and using allele-specific CRISPR knock-out to repair the phenotype. cell.com/stem-cell-reports/f…
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@LabLamba just completed a decade in existence. I am so thankful to present and past members as well as all my mentors, friends and collaborators who have made this possible. Thank you to the lab for the fun surprise party!
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Happy to announce that our paper describing low cost production and testing of a clinical grade gene therapy vector for the treatment of patients with MAK-associated retinitis pigmentosa has been published @GeneTherapy_SN #GeneTherapy #stemcells #IRD
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We @LabLamba are looking for post-docs interested in developing creative projects on stem cell derived retinal organoids for developmental and retinal disease modeling. DM me @LabLamba or email me at deepak.lamba@UCSF.edu
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Excited to share our latest work from the @MeyerLab, led by @kikiexplains cell.com/stem-cell-reports/f…

Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived...

In this article, Fligor and colleagues present the development of a three-dimensional assembloid model for retinofugal projections, comprising retinal, thalamic, and cortical organoids. Results...

cell.com
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@LabLamba is looking for postdocs/technicians for iPSC-disease modeling projects in the lab. jobbank.isscr.org/job/postdo… Please retweet and spread the ad! Thanks!
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Another one bites the neurons. Impressive serial EM study of mouse visual cortex during critical period. Oligodendrocyte precursors engulf axons & contain phagolysosomes and neuron-derived RNAs . @JoJoBuchanan1 da Costa lab @AllenInstitute biorxiv.org/content/10.1101/…
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Are PhD students aware of Open Grants? This is an online repository for applications that got funded or rejected. Applicants share their essays as examples for future applicants. (E.g. NSF, NIH, Ford, etc). Please share! #NSFGRFP #NIH #AcademicTwitter ogrants.org/
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Our neighbors and friends in the OBM lab in eLife today! They used scRNA-seq to characterize the development of the crista (responsible for sensing rotation). Little was known about this structure so read it to learn about new cell types! @OliviaMcdonogh elifesciences.org/articles/6…

Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse...

The elucidation of the cellular composition of the crista and the genes expressed in each cell type is a critical step toward understanding inner ear development, function, and vestibulopathies.

elifesciences.org
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LambaLab retweeted
jobRxiv
@jobRxiv15 May 2021
Postdoctoral Position at UCSF-Ophthalmology in Stem Cell Research with @LabLamba University of California, San Francisco, USA jobrxiv.org/job/university-o… #ScienceJobs #StemCells

Postdoctoral Position at UCSF-Ophthalmology in Stem Cell Research

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org
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