@martinperaJAX

Professor @jacksonlab, stem cell biologist

 Bar Harbor, ME
jax.org/research-and-faculty/faculty/martin-pera
Joined July 2019
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  • Followers2.6K
9Media
The Genetic Discovery (GeDi) resource: Deep characterization of a multi-ancestry panel of human reference iPSCs for functional genomic studies biorxiv.org/content/10.64898…
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Multi-omic profiling of 85 iPSC lines from familial dementia reveals c… sciencedirect.com/science/ar…
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Cooperativity enables widespread role of low-affinity motifs in chroma… sciencedirect.com/science/ar…
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Wu, H., Hu, Y., Yu, H. et al. Modelling mouse embryogenesis from chemically induced totipotent stem cells. Nature (2026). doi.org/10.1038/s41586-026-1…

Modelling mouse embryogenesis from chemically induced totipotent stem cells

Nature - A mouse embryo model derived from chemically induced totipotent-like stem cells progresses through key developmental milestones, including gastrulation, embryonic axis formation,...

nature.com
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A fluctuation test for gastruloid heterogeneity: Cell cell.com/cell/fulltext/S0092…

A fluctuation test for gastruloid heterogeneity

Organoids grown side by side under identical conditions vary unpredictably, a longstanding obstacle to their use. Adapting the logic of a classic fluctuation test to gastruloids grown from single...

cell.com
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Huang, J., Li, R., Zeng, L. et al. Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of advanced maternal age: a randomized, clinical trial. Nat Commun 17, 10634 (2026). doi.org/10.1038/s41467-026-7…

Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of...

Nature Communications - Non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) can detect embryo chromosomal aneuploidy by analyzing the cell-free DNA in embryo culture media, but...

nature.com
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Simplified in vitro generation of human gastruloids for modelling early development journals.biologists.com/dev/…

Simplified in vitro generation of human gastruloids for modelling early development

The purpose of this study was to optimize the efficiency, cost and reproducibility of human gastruloid formation by testing and adjusting individual parameters using four human pluripotent stem cell...

journals.biologists.com
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WNT/β-catenin increases 3D chromatin mobility and reorganisation during posterior cell state transitions biorxiv.org/content/10.64898…

WNT/β-catenin increases 3D chromatin mobility and reorganisation during posterior cell state...

Chromatin mobility, the exploration of 3D conformations by the chromatin fibre, is implicated in transcription and DNA repair, and is thought to decrease progressively as cells differentiate. Here,...

biorxiv.org
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Capture of Post-Pluripotency Human Neuromesodermal and Neural Tube Axial Stem Cell States biorxiv.org/content/10.1101/…

Capture of Post-Pluripotency Human Neuromesodermal and Neural Tube Axial Stem Cell States

The capture of pluripotent and adult tissue stem cells has transformed biomedicine, yet stable stem cell states between these developmental extremes have remained elusive. Here, we capture two human...

biorxiv.org
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Intra-uterine position modulates lifelong hippocampal neurogenesis and anxiety-related behavior biorxiv.org/content/10.64898…
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Disease-associated mutations directionally modulate epigenetic age in iPSC-derived tissues biorxiv.org/content/10.64898…

Disease-associated mutations directionally modulate epigenetic age in iPSC-derived tissues

Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) resets epigenetic age, creating a major challenge for modeling age-associated cellular states and limiting the use of iPSCs in...

biorxiv.org
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Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis biorxiv.org/content/10.64898…

Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis

A comprehensive cell fate map of mammalian embryogenesis has remained out of reach given the scale, cellular diversity, and non-deterministic nature of development in utero . Here, we use PEtracer to...

biorxiv.org
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Ramesan, S., Mason, J., Kumar, S.S. et al. A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair. Nat Neurosci (2026). doi.org/10.1038/s41593-026-0…

A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair

Nature Neuroscience - Researchers engineered a human stem cell-derived model that recapitulates myelin damage and repair in the central nervous system, enabling the study of remyelination and drug...

nature.com
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Combination of Blastocyst Complementation and Omics Allows Fast Evaluation of Human Pathogenic Mutations in Mice academic.oup.com/ajrcmb/arti…

Combination of Blastocyst Complementation and Omics Allows Fast Evaluation of Human Pathogenic...

AbstractRationale. Development of in vivo animal models carrying patient-derived pathogenic gene variants is critical for dissecting molecular mechanisms c

academic.oup.com
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Yücel, A.D., Molière, A. & Gladyshev, V.N. Written in development and lost in ageing: the grammar of cellular identity. Nature 658, 45–54 (2026). doi.org/10.1038/s41586-026-1…

Written in development and lost in ageing: the grammar of cellular identity

Nature - Ageing reflects progressive decanalization of mammalian cell identity, driven by erosion of a regulatory grammar written during development.

nature.com
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Rengarajan, A., Wang, S., Lin, CW. et al. The endo-lysosomal system drives lumen formation in a human epiblast model. Nat Commun 17, 10255 (2026). doi.org/10.1038/s41467-026-7…

The endo-lysosomal system drives lumen formation in a human epiblast model

Nature Communications - Rengarajan et al. identify RAB35- and RAB7-regulated endo-lysosomal dynamics as important drivers of the formation of the apicosome and lumen formation in a model of human...

nature.com
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🧬 Highly related @NatureGenet paper from @binzmit group, using nucleosome-resolution chromatin modeling: Euchromatin forms condensed domains with short active regions on the surface nature.com/articles/s41588-0… Congratulations! 🎉

Euchromatin forms condensed domains with short active regions on the surface

Nature Genetics - Simulations integrating micro-C and imaging data provide a coherent view of chromatin organization from nucleosomes to clutches to domains, revealing that most regions form...

nature.com
Kazuhiro Maeshima@kazu_maeshimaSep 8
Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @NatureGenet reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗nature.com/articles/s41588-0… (1/2)
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SWI/SNF-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids biorxiv.org/content/10.64898…

SWI/SNF-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos...

Establishment of cell lineages during development is regulated by transcription factors binding at cis-regulatory elements to activate gene regulatory programs. Many transcription factors require...

biorxiv.org
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Mitochondrial priming in human germ cell tumors is dependent on MCL1 and BCL2L1 biorxiv.org/content/10.64898…

Mitochondrial priming in human germ cell tumors is dependent on MCL1 and BCL2L1

Germ cell tumors (GCTs) are highly sensitized to cell death in response to DNA damaging agents, a property that underlies the success of current chemotherapeutic regimens. To address the molecular...

biorxiv.org
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Jokhai, R.T., Dundes, C.E., Ahsan, H.S. et al. Two parallel neural ectoderm progenitors contribute to the developing brain. Nat Neurosci (2026). doi.org/10.1038/s41593-026-0…

Two parallel neural ectoderm progenitors contribute to the developing brain

Nature Neuroscience - This study shows that the brain arises from two distinct progenitors: one forms the forebrain and midbrain, whereas the other generates the hindbrain. These insights enable...

nature.com
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