We use brain organoid and chimeric-brain platforms to uncover disease mechanisms and engineer human microglia for brain repair.
Piscataway, NJ 08854
Joined February 2020
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Peng Jiang Lab retweeted
A cross-species AAV platform for precise microglial interrogation: @NeuroCellPress cell.com/neuron/fulltext/S08…
Peng Jiang Lab retweeted
🎉New in Neuron! We identified that microglia-derived soluble DLK1 links aging to hypomyelination. In mouse and human iPSC models, telomere shortening drives microglial senescence, ↑sDLK1, and impaired oligodendrocyte maturation and neuronal activity. cell.com/neuron/fulltext/S08…
Peng Jiang Lab retweeted
From @Nature : The aging human brain is more dynamic than we thought. Somatic mutations revealed marrow-derived cells in every human brain studied, sometimes forming a large share of microglia, Clonal hematopoiesis was also linked to a lower risk of AD. nature.com/articles/s41586-0…
Peng Jiang Lab retweeted
Beautiful study lead by Julia, Howard, Siddhartha and co. follows the ontogeny of microglia in human aging
nature.com/articles/s41586-0…
Peng Jiang Lab retweeted
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease @NatureNeuro
nature.com/articles/s41593-0…
Peng Jiang Lab retweeted
Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo alz-journals.onlinelibrary.w… @alzdemjournals
Peng Jiang Lab retweeted
Returned to this platform to amplify this beautiful work! Well done Sonia and all!
A major step forward and key experimental insights for how we advance this for many diseases.
Microglia replacement via vascular delivery and no toxic preconditioning? Now THAT is something I can get excited about. In our new paper we find that microglia replacement can now be achieved by peripheral delivery w/ no irradiation or chemo required.
👉 doi.org/10.1016/j.ymthe.2025…
Peng Jiang Lab retweeted
We are pleased to share our newest publication from the @BlurtonJonesLab, "CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies" sciencedirect.com/science/ar…
Peng Jiang Lab retweeted
We are excited to announce the 3rd ASCN Symposium, Jan 28-30, 2026 in Houston! Featuring a keynote by Dr Hongkui Zeng @HongkuiZeng @AllenInstitute and 10 exciting sessions. Join us for cutting-edge talks, trainee award & networking!
Register at sfnchinese.org
Peng Jiang Lab retweeted
Nobel Laureate Professor Sir John Gurdon dies aged 92 | University of Cambridge cam.ac.uk/research/news/nobe…
Peng Jiang Lab retweeted
Microglia replacement halts the progression of microgliopathy in mice and humans | @ScienceMagazine science.org/doi/10.1126/scie…
Peng Jiang Lab retweeted
🧩Today is #AutisticPrideDay! Up to 18% of people w/#DownSyndrome also have #Autism. At GLOBAL we're committed to supporting & celebrating people w/the dual diagnosis like our brilliant #GLOBALAmbassador, Micah Quinones! Watch his AMAZING story here: bit.ly/3HLHEBu
Peng Jiang Lab retweeted
Online now: Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies dlvr.it/TKQfYD
Peng Jiang Lab retweeted
Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases sciencedirect.com/science/ar…
Peng Jiang Lab retweeted
Yes! People with Down syndrome and AD neuropathology can be resilient to dementia!
Happy to share our paper: alz-journals.onlinelibrary.w…
Recent UPitt article highlights the important work of Co-Director Professor Head @ElzHead , Jr-Jiun Liou, postdoctoral scholar at UPitt, and colleagues focused on AD in DS and a unique case report of a woman with Down syndrome showing resiliency. news.engineering.pitt.edu/an…
Peng Jiang Lab retweeted
So where does the saved money go??
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above what many major foundations allow and much lower than the 60%+ that some institutions charge the government today. This change will save more than $4B a year effective immediately.
Peng Jiang Lab retweeted
Excited to share our work, new in @ScienceMagazine: science.org/doi/10.1126/scie…. We explored how sex chromosomes, gonadal hormones, and their interaction shape cellular responses in aging and #Alzheimers mouse models. This led to key insights on Tlr7 and neurodegeneration 🧵(1/5)
Peng Jiang Lab retweeted
Please consider applying..we have amazing faculty and research..come join us!
Wow,@UCIrvine is on a neuroscience hiring streak!
Next up is a hard money tenure-track Asst Prof position @UCIneurobio for mol. neurobiol. of Alzheimer’s disease or other neurodegenerative disorders
Apply starting Nov 1 to join our thriving group!
recruit.ap.uci.edu/JPF09317
Peng Jiang Lab retweeted
The Center for Neuroimmunology and Glial Biology @CNG_UTHealth @McGovernMed has multiple open-rank faculty openings! Come to join us to explore the non-neuronal cells and harness the power of brain immunity. DM or email me if you are interested. nature.com/naturecareers/job…
Peng Jiang Lab retweeted
🚨UVa Neurodegeneration job alert!! UVa Neuroscience is hiring multiple TT faculty in neurodegenerative disease research. If you're looking for a vibrant scientific community with wonderful colleagues then check it out! Please share/rt! @uvavpr @BIG_Center_UVA @UVANeurology